Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yoshiyuki Taoda"'
Publikováno v:
Expert Opinion on Therapeutic Patents. 33:51-66
Autor:
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu, Shiho Yamamoto, Yuki Maruyama, Yoshiyuki Taoda, Koji Kasamatsu, Takahiro Suto, Kensuke Kouki, Atsufumi Nakahashi, Sho Kawashima, Takao Sanaki, Shinsuke Toba, Kentaro Uemura, Tohru Mizutare, Shigeru Ando, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Takafumi Sato, Teruhisa Kato, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6499-6512
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines,
Autor:
Shinsuke Toba, Akihiko Sato, Makoto Kawai, Yoshiyuki Taoda, Yuto Unoh, Shinji Kusakabe, Haruaki Nobori, Shota Uehara, Kentaro Uemura, Keiichi Taniguchi, Masanori Kobayashi, Takeshi Noshi, Ryu Yoshida, Akira Naito, Takao Shishido, Junki Maruyama, Slobodan Paessler, Michael J. Carr, William W. Hall, Kumiko Yoshimatsu, Jiro Arikawa, Keita Matsuno, Yoshihiro Sakoda, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Hiroshi Kida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Viral hemorrhagic fevers caused by members of the order Bunyavirales comprise endemic and emerging human infections that are significant public health concerns. Despite the disease severity, there are few therapeutic options available, and therefore
Autor:
Yoshiyuki Taoda, Akihiko Sato, Shinsuke Toba, Yuto Unoh, Makoto Kawai, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 83:129175
Autor:
Yoshiyuki Taoda, Toshiyuki Akiyama, Tomokazu Yoshinaga, Masayoshi Miyagawa, Kenji Tomita, Kenji Takaya, Kazunari Hattori, Shinya Shano, Takao Shishido, Akihiko Sato, Kazuya Yasuo, Makoto Kawai, Ryu Yoshida, Chika Takahashi-Kageyama
Publikováno v:
Journal of Medicinal Chemistry. 62:8101-8114
The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N
Autor:
Shoji Shinomoto, Yutaka Nishino, Naoki Miyake, Yuki Fukui, Masahiko Nagai, Tatsuro Yasukata, Takao Ooyama, Toshikazu Hakogi, Yasunori Aoyama, Yoshiyuki Taoda, Daisuke Yamada, Hiroshi Yoshida
Publikováno v:
Organic Process Research & Development. 23:558-564
A practical and scalable synthetic method to obtain dolutegravir sodium (1) was established starting from the readily accessible material maltol (2). This synthetic method includes a scalable oxidation process of maltol and palladium-catalyzed amidat
Autor:
Yoshiyuki, Taoda, Toshiyuki, Akiyama, Kenji, Tomita, Misato, Fujiwara-Kitamura, Yoshinori, Tamura, Takashi, Kawasuji, Eriko, Matsuoka, Erika, Akihisa, Takahiro, Seki, Tomokazu, Yoshinaga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 64:128664
We have been conducting exploratory research to develop human immunodeficiency virus type-1 (HIV-1) integrase-LEDGF/p75 allosteric inhibitors (INLAIs). Here, we report on a newly designed compound with a tricyclic scaffold that shows promise as an in
Autor:
Yoshiyuki Taoda, Takeshi Noshi, Ryu Yoshida, Makoto Kawai, Kenji Tomita, Yasushi Hasegawa, Masayoshi Miyagawa, Toshiyuki Akiyama, Takao Shishido
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(22)
This work describes a set of discovery research studies of an influenza cap-dependent endonuclease (CEN) inhibitor with a carbamoyl pyridone bicycle (CAB) scaffold. Using influenza CEN inhibitory activity, antiviral activity and pharmacokinetic (PK)
Autor:
Takahiro Seki, Toshiyuki Akiyama, Yoshiyuki Taoda, Eriko Matsuoka, Tsutomu Iwaki, Takashi Kawasuji, Tomokazu Yoshinaga, Shuichi Sugiyama, Erika Akihisa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127742
We have discovered HIV-1 novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a pyridine scaffold forming an intramolecular hydrogen bond. Scaffolds containing a pyridine moiety have been studied extensively and we have already reported
Autor:
Yasuhiko Kanda, Maki Tomari, Tohru Horiguchi, Kayoko Hata, Hiroyuki Kai, Emiko Taniguchi, Tsuyoshi Hasegawa, Shunji Shinohara, Takayuki Kameyama, Yoshiyuki Taoda, Miho Oohara, Shinji Shimada, Yukio Takahara, Yoshikazu Tanaka, Naoko Kurihara, Yukio Tada, Hiroyuki Tobinaga, Chie Takeyama, Shigenori Yagi, Shoichi Yamamoto, Fumiyo Takahashi, Kentarou Asahi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127636
The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit comp