Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Yoshiyuki Sugimoto"'
Autor:
Yoshiyuki Sugimoto, Yozo Kojima, Atsushi Inayoshi, Kazuaki Inoue, Hiroko Miura-Kusaka, Kiyotoshi Mori, Osamu Saku, Hiroshi Ishida, Eri Atsumi, Yoshisuke Nakasato, Shiro Shirakura, Shin-ichiro Toki, Katsumi Shinoda, Nobuyuki Suzuki
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 3, Pp 256-266 (2013)
Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat. During inflammation, TRPV1 is reported to be sens
Externí odkaz:
https://doaj.org/article/d34e73b9e5ae401c9b528731d20585d5
Autor:
Takuya Okimoto, Hideki Yagi, Ken Ashizawa, Kouichiro Yamazaki, Koji Ebihara, Satoru Okamoto, Kazuhiko Horino, Munetaka Kurokawa, Yoshiyuki Sugimoto, Seiji Kumagai, null Tanaka, Masaru Takechi, Mitsuru Ekawa, Yoshihiro Yoneda
Publikováno v:
2023 Optical Fiber Communications Conference and Exhibition (OFC).
An InP-based coherent receiver PIC with waveguide PDs demonstrates 80-GHz bandwidth and high responsivity of 0.156 A/W at a wavelength of 1.55 µm. A coherent receiver module with PICs and TIAs performs sufficient characteristics for 128-GBaud transm
Publikováno v:
Optical Fiber Communication Conference (OFC) 2022.
We demonstrate a 128-Gbit/s/λ optical transmitter with newly developed DC-coupled linear driver IC for electro-absorption modulator. High-quality PAM-4 eye diagram with higher extinction ratio is obtained with low-power consumption, which is suitabl
Autor:
Eiichi Banno, Hiroshi Uemura, Tsutomu Ishikawa, Yasutaka Mizuno, Takuya Okimoto, Mitsuru Ekawa, Seiji Kumagai, Nakayama Kenichi, Keiji Tanaka, Taichi Misawa, Takatoshi Kato, Masaru Takechi, Hiroshi Hara, Naoya Kono, Yoshiyuki Sugimoto, Munetaka Kurokawa, Katsumi Uesaka
Publikováno v:
ECOC
Autor:
Keiji Tanaka, Daisuke Umeda, Shoichi Ogita, Tomoyuki Funada, Tanaka Naruto, Yoshiyuki Sugimoto
Publikováno v:
OFC
We report the world's first receiver optical sub-assembly equipped with 25G burstmode TIA which is applicable for 50G-EPON OLT transceiver. We demonstrate its 25G/10G dual-rate burst-mode receiver characteristics.
Publikováno v:
OFC
We present a compact 212.5-Gbit/s transmitter optical sub-assembly equipped with directly modulated lasers and quad 53.125-Gbit/s linear driver. We demonstrate high-quality and high-output-power operation with low-power consumption (1.01 W), which is
Autor:
Kazuyasu Nakamura, Kazunori Kato, Miki Yamaguchi, Hirofumi Hamada, Masahiro Ikeda, Yoshiyuki Sugimoto
Publikováno v:
Anticancer research. 36(11)
Background Multiple factors affect the in vivo antitumor activity of antibody-based therapeutics; however, the influence of cell surface retention on antibody-dependent cellular cytotoxicity (ADCC) is not fully understood. Here we evaluated the impor
Autor:
Hiroshi Kodaira, Osamu Saku, Yoshimitsu Kato, Yoshisuke Nakasato, Yoshiyuki Sugimoto, Eri Atsumi, Shiro Shirakura, Hiroshi Ishida
Publikováno v:
Journal of Medicinal Chemistry. 55:3436-3451
We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing is
Publikováno v:
Drug Delivery System. 26:611-621
抗体医薬の臨床効果を高めるため,抗体が持つエフェクター機能を増強する試みがなされている.数多くの試行錯誤の結果,Fc領域の特定のアミノ酸の改変,あるいは糖鎖の修飾により
Autor:
Yoshiyuki Sugimoto, Sagano Shiina, Miki Yamaguchi, Takako Ichikawa-Ando, Kazunori Kato, Hirofumi Misaka, Kazuyasu Nakamura, Kiminori Nakamura, Kensuke Myojo, Hirofumi Hamada, Masahiro Ikeda
Publikováno v:
Biochemical and biophysical research communications. 458(4)
TROP-2 is a type Ⅰ transmembrane glycoprotein that is highly expressed in various epithelial cancer cells, and its increased expression correlates with poor prognosis. Although several anti-TROP-2 antibodies have been described, they were found uns