Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yoshiyuki Soeda"'
Autor:
Kenji Tagai, Harutsugu Tatebe, Sayo Matsuura, Zhang Hong, Naomi Kokubo, Kiwamu Matsuoka, Hironobu Endo, Asaka Oyama, Kosei Hirata, Hitoshi Shinotoh, Yuko Kataoka, Hideki Matsumoto, Masaki Oya, Shin Kurose, Keisuke Takahata, Masanori Ichihashi, Manabu Kubota, Chie Seki, Hitoshi Shimada, Yuhei Takado, Kazunori Kawamura, Ming-Rong Zhang, Yoshiyuki Soeda, Akihiko Takashima, Makoto Higuchi, Takahiko Tokuda
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/7c34e3413c9e47fabe9c650ddabe1a10
Autor:
Yoshiyuki Soeda, Emi Hayashi, Naoko Nakatani, Shinsuke Ishigaki, Yuta Takaichi, Taro Tachibana, Yuichi Riku, James K. Chambers, Riki Koike, Moniruzzaman Mohammad, Akihiko Takashima
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Prior to the formation of amyloid fibrils, the pathological hallmark in tau-related neurodegenerative disease, tau monomers aggregate into a diverse range of oligomers. Granular tau oligomers, consisting of approximately 40 tau protein molec
Externí odkaz:
https://doaj.org/article/bca48ca3cae24e98acfdf58791c53295
Autor:
Hiroko Bannai, Akihiko Takashima, Yoshiyuki Soeda, Hideaki Yoshimura, Gen Matsumoto, Naruhiko Sahara, Michio Hiroshima, Mitsuru Hattori, Takeharu Nagai
Publikováno v:
Biophysics and Physicobiology, Vol 21 (2024)
Externí odkaz:
https://doaj.org/article/35e10b05dbb441129c568e7a67d24e95
Autor:
Fumiko Konishi, Tadasu Furusho, Yoshiyuki Soeda, Jun Yamauchi, Shoko Kobayashi, Masatoshi Ito, Takuma Araki, Sarasa Kogure, Akihiko Takashima, Susumu Takekoshi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrill
Externí odkaz:
https://doaj.org/article/13a35b293fc84c849041f2bd9c826ac3
Autor:
Yuta Takaichi, James K. Chambers, Kei Takahashi, Yoshiyuki Soeda, Riki Koike, Etsuko Katsumata, Chiaki Kita, Fuko Matsuda, Makoto Haritani, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. The AD-related pathology has
Externí odkaz:
https://doaj.org/article/ab69a223644641be929c201f22c938ff
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100026- (2022)
Externí odkaz:
https://doaj.org/article/d56c87fd243e4c23906580532bbb22b2
Publikováno v:
Aging Brain, Vol 1, Iss , Pp 100022- (2021)
Glycogen synthase kinase 3β (GSK-3β) is a therapeutic target for various age-related neurodegenerative diseases. It is linked to the two main pathological features of Alzheimer’s disease (AD), tau and amyloid β (Aβ); GSK-3β is a major candidat
Externí odkaz:
https://doaj.org/article/15607119135e4c048727e3e9a5e033cf
Autor:
Yoshiyuki Soeda, Akihiko Takashima
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Microtubule-associated protein tau is characterized by the fact that it is an intrinsically disordered protein due to its lack of a stable conformation and high flexibility. Intracellular inclusions of fibrillar forms of tau with a β-sheet structure
Externí odkaz:
https://doaj.org/article/15cff6fba3d04a3fac912a88ffce86ef
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 120-126 (2017)
Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neuron
Externí odkaz:
https://doaj.org/article/ab3447898adc45fa9c8ad59a35363bd6
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Tau is a microtubule-associated protein, localizing mainly in the axon of mature neurons. Phenotypic analysis of Tau knockout mice has revealed an impairment of synaptic plasticity but without gross changes in brain morphology. Since we previously de
Externí odkaz:
https://doaj.org/article/7ae1cc98d23c4a1eb11e8d0bcce5df6c