Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Yoshiyuki Kuchino"'
Autor:
Yoshiyuki Kuchino, Yoshiteru Ida, Yasuaki Hirai, Motonori Fukumura, Kazuo Toriizuka, Hidehiro Ando
Publikováno v:
Journal of Natural Medicines. 63:181-188
Achyranthoside H methyl ester (AH-Me) is an oleanolic acid saponin derivative isolated from the roots of Achyranthes fauriei through diazomethane treatment. AH-Me exhibited significant cytotoxicity against human breast cancer MCF-7 and MDA-MB-453 cel
Autor:
Yumiko Hori, Yasuaki Hirai, Yoshiteru Ida, Yoshiyuki Kuchino, Motonori Fukumura, Kazuo Toriizuka, Hidehiro Ando
Publikováno v:
Journal of Natural Medicines. 62:57-62
Two oleanolic acid saponins named achyranthosides G (1) and H (2) were newly isolated from Achyranthes fauriei root as methyl esters in addition to methyl esters of achyranthosides A - F and five oleanolic acid glucuronides (chikusetsusaponins IVa, V
Autor:
Masamitsu Tanaka, Yoshiro Otsuki, Haruhiko Sugimura, Chifumi Kitanaka, Takaharu Kamo, Yoshiyuki Kuchino
Publikováno v:
Journal of Biological Chemistry. 278:5132-5140
The transcription factor c-Myc is important for the control of cell growth, cell cycle progression, neoplasia, and apoptotic cell death. Recently, c-Myc-binding proteins, which bind either to the N-terminal domain or the C-terminal domain of c-Myc, h
Autor:
Akiko Kokubu, Takamasa Kayama, Jun Sunayama, Yoshiyuki Kuchino, Chifumi Kitanaka, Arata Tomiyama, Kaori Sakurada
Publikováno v:
Biochemical and Biophysical Research Communications. 291:1022-1030
Cell-permeable pancaspase inhibitors such as zAsp-CH2-DCB and zVAD-fmk are widely used to examine the involvement of caspases in cell death models. While examining the caspase-dependence of staurosporine (STS)-induced neuroblastoma cell death, we fou
Autor:
Toshihiro Mochizuki, Makoto Nakane, Nobuhito Saito, Akio Asai, Hideki Katagiri, Akira Tamura, Takaaki Kirino, Tomoichiro Asano, Chifumi Kitanaka, Sakae Tanaka, Yoshiyuki Kuchino
Publikováno v:
Journal of Biological Chemistry. 277:2790-2797
A growing body of evidence now suggests that programmed cell death (PCD) occurs via non-apoptotic mechanisms as well as by apoptosis. In contrast to apoptosis, however, the molecular mechanisms involved in the regulation of non-apoptotic PCD remain o
Autor:
Tomonari Muramatsu, Aihua Liang, Claudia Brünen-Nieweler, Hildburg Beier, Klaus Heckmann, Yoshiyuki Kuchino
Publikováno v:
Gene. 262:161-168
Amplification of macronuclear DNA of the ciliate Euplotes octocarinatus revealed the presence of two genes encoding putative polypeptide release factors (RFs) of the codon specific class-I type. They are named eRF1a and eRF1b, respectively. cDNA ampl
Publikováno v:
Cancer Chemotherapy and Pharmacology. 45:149-156
Purpose: Although chemotherapeutic protocols that include chloroethylnitrosoureas (CENUs), such as 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), have be
Autor:
Yoshiyuki Kuchino, Hiroko Ao, Masaru Tanokura, Kenji Takahashi, Satoru Watanabe, Tomonari Muramatsu, Yoshie Hirayama
Publikováno v:
European Journal of Biochemistry. 266:811-819
The gene encoding Lon protease was isolated from an extreme thermophile, Thermus thermophilus HB8. Sequence analysis demonstrated that the T. thermophilus Lon protease gene (TT-lon) contains a protein-coding sequence consisting of 2385 bp which is
Autor:
Hironobu Yamana, Kohji Noguchi, Chifumi Kitanaka, Toshihiro Mochizuki, Yoshiyuki Kuchino, Akiko Kokubu
Publikováno v:
Journal of Biological Chemistry. 274:32580-32587
The expression of c-myc promotes cell proliferation and also sensitizes cells to various extracellular apoptotic stimuli. However, signal pathways regulating the function of Myc proteins during apoptosis are unknown. c-Jun N-terminal kinase (JNK) is
Autor:
Yoshiyuki Kuchino, Chifumi Kitanaka
Publikováno v:
Cell Death & Differentiation. 6:508-515
Cell death is generally classified into two large categories: apoptosis represents active, programmed cell death, while necrosis represents passive cell death without underlying regulatory mechanisms. Recent progress revealed that caspases, a family