Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yoshiyuki Igawa"'
Autor:
Akifumi, Kurata, Takashi, Eto, Junko, Tsutsumi, Yoshiyuki, Igawa, Yasuhiro, Nishikawa, Hitoshi, Ishizuka
Publikováno v:
Clinical Pharmacology in Drug Development. 11:957-965
We assessed the bioequivalence of a single dose of 5-mg of esaxerenone administered as an orally disintegrating tablet (ODT) with the conventional oral tablet in healthy Japanese men. This single-center, open-label, randomized, two-drug, two-stage cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adff67cce0c2f23dbe56d097f4d88fe
https://doi.org/10.1002/cpdd.1087
https://doi.org/10.1002/cpdd.1087
Publikováno v:
Folia Pharmacologica Japonica. 155:340-350
Esaxerenone is a novel non-steroidal mineralocorticoid receptor antagonisit (MR blocker), whose unique binding to the MR-ligand domain yields a stronger MR antagonistic effect and higher selectivity than existing MR antagonisits. Esaxerenone was appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf2dcff70abc60aa673d06acd8e42d3
https://doi.org/10.1254/fpj.20016
https://doi.org/10.1254/fpj.20016
Autor:
Nobuhiro Narii, Yoshiari Shimmyo, Kenji Murata, Tetsuya Toba, Hidekazu Inoue, Takahiro Matsumoto, Hiroki Sakai, Naohiro Takemoto, Yoshiyuki Igawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2332-2337
To avoid production of a phospholipidosis-inducing metabolite, we replaced the amide structure of SUN13837 (1) with a 1,2,3-triazole. The resulting 1,2,3-triazole analog of 1 (compound 2) displayed greater neuroprotective activity than 1. Structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baee5e1f6c21724d69605ac50218b352
https://doi.org/10.1016/j.bmcl.2019.06.016
https://doi.org/10.1016/j.bmcl.2019.06.016
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 155(5)
Esaxerenone is a novel non-steroidal mineralocorticoid receptor antagonisit (MR blocker), whose unique binding to the MR-ligand domain yields a stronger MR antagonistic effect and higher selectivity than existing MR antagonisits. Esaxerenone was appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::423b6eb3d329b8fcdb35f8a133dcd69e
https://pubmed.ncbi.nlm.nih.gov/32879177
https://pubmed.ncbi.nlm.nih.gov/32879177
Autor:
Yoshiari Shimmyo, Naohiro Takemoto, Yoshiyuki Igawa, Shinya Ueno, Nobuhiro Narii, Kenji Murata, Tetsuya Toba, Hidekazu Inoue, Hiroki Sakai
Publikováno v:
Bioorganicmedicinal chemistry. 28(14)
SUN13837 (1), a fibroblast growth factor receptor modulator, has been an attractive candidate for treating neurodegenerative diseases. However, one of its metabolites, N-benzyl-4-(methylamino)piperidine (BMP), turned out to possess phospholipidosis-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b7a19f61b8950e9f00b9775a622d5b
https://pubmed.ncbi.nlm.nih.gov/32616184
https://pubmed.ncbi.nlm.nih.gov/32616184
Autor:
Hitoshi Ishizuka, Akiko Watanabe, Tomoko Ishizuka, Takako Shimizu, Yoshiyuki Igawa, Makiko Yamada
Publikováno v:
European Journal of Clinical Pharmacology. 78:75-75
Esaxerenone is a novel, oral, nonsteroidal treatment for hypertension. Physiologically based pharmacokinetic (PBPK) modelling was performed to predict the drug–drug interaction (DDI) effect of cytochrome P450 (CYP)3A modulators on esaxerenone pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eeece460d2e551cc30c6cec424509c0
https://doi.org/10.1007/s00228-021-03211-z
https://doi.org/10.1007/s00228-021-03211-z
Autor:
Naoya Wada, Kazuishi Kubota, Yoshiyuki Igawa, Kayoko Ohura, Kana Matsumoto, Yasuhiro Uno, Teruko Imai, Maori Tanaka, Akiko Kasahara
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(3)
In contrast to a single human carboxylesterase 2 (CES2) isozyme (hCE2), three CES2 genes have been identified in cynomolgus monkeys: mfCES2A, mfCES2B, and mfCES2C. Although mfCES2A protein is expressed in several organs, mfCES2B is a pseudogene and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da52f48f21e1bc8f62c7e7d39d6bd5a
https://pubmed.ncbi.nlm.nih.gov/31836607
https://pubmed.ncbi.nlm.nih.gov/31836607
Autor:
Teruko Imai, Shotaro Uehara, Seiya Fujiwara, You Nishizawa, Kayoko Ohura, Yasuhiro Uno, Takatsugu Hirokawa, Yoshiyuki Igawa
Publikováno v:
Molecular Pharmaceutics. 13:3176-3186
Cynomolgus monkeys, used as an animal model to predict human pharmacokinetics, occasionally show different oral absorption patterns to humans due to differences in their intestinal metabolism. In this study, we investigated the differences between in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404329a362608291b8ba57ff0aef6b1e
https://doi.org/10.1021/acs.molpharmaceut.6b00394
https://doi.org/10.1021/acs.molpharmaceut.6b00394
Carboxylesterase (CES) is important for the detoxification of a wide range of drugs and xenobiotics. In this study, the hepatic level of CES2 mRNA was examined in cynomolgus macaques used widely in preclinical studies for drug metabolism.Three CES2 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7597d56fa0e0ca3a03e92ba2f7bcc47
Autor:
Ryoko Ogino, Nobuhiro Ueno, Yasuhiro Morita, Toyofumi Masuda, Tetsushi Oka, Teruyoshi Inoue, Shinya Ueno, Taisuke Kadoshima, Tetsuya Toba, Takafumi Noshita, Norihito Murayama, Naohiro Takemoto, Yoshiyuki Igawa, Wiebke Schulze
Publikováno v:
Brain Research. 1594:71-81
Basic fibroblast growth factor (FGF-2/bFGF) possesses neuroprotective activity and promotes cell proliferation. In this study, the novel synthetic compound 4-({4-[[(4-amino-2,3,5,6-tetramethylanilino)acetyl](methyl)amino]-1-piperidinyl}methyl)benzami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c955fa82dd2f43f9a7c294da8689209
https://doi.org/10.1016/j.brainres.2014.10.066
https://doi.org/10.1016/j.brainres.2014.10.066