Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yoshiyuki Furuta"'
Autor:
Akikazu Nakamura, Shunsuke Nomura, Shoko Hara, Thiparpa Thamamongood, Taketoshi Maehara, Tadashi Nariai, Shasha Khairullah, Kay Sin Tan, Kenko Azuma, Ayako Chida‐Nagai, Yoshiyuki Furutani, Takahiro Hori, Koji Yamaguchi, Takakazu Kawamata, Constantin Roder, Hiroyuki Akagawa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Moyamoya vasculopathy secondary to various genetic disorders is classified as moyamoya syndrome (MMS). Recent studies indicate MMS occurs due to a combination of genetic modifiers and causative mutations for the primary genetic disorders. We
Externí odkaz:
https://doaj.org/article/52500fa5aa9c453988b7c7d29f5e708a
Autor:
Yoshiaki Watanabe, Haruhiko Sato, Hidetomo Kitamura, Tomoya Kotake, Yoshikazu Nishimura, Masaru Shimizu, Takashi Emura, Kotaro Ogawa, Toru Esaki, Toshito Nakagawa, Akemi Mizutani, Yoshiyuki Furuta, Shinichi Arai, Hiroshi Noda, Masateru Ohta, Tatsuya Tamura, Yoshiaki Isshiki
Publikováno v:
Journal of Medicinal Chemistry. 63:5089-5099
We have previously shown that the oral administration of the small molecule hPTHR1 agonist PCO371 and its lead compound, 1 (CH5447240) results in PTH-like calcemic and hypophostemic activity in thyroparathyroidectomized rats. However, 1 was converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e990e3b015767e8e07afcf1625e08030
https://doi.org/10.1021/acs.jmedchem.9b01743
https://doi.org/10.1021/acs.jmedchem.9b01743
Autor:
Masaru Shimizu, Yoshikazu Nishimura, Masateru Ohta, Toshito Nakagawa, Yoshiyuki Furuta, Naoki Okamoto, Yoshiaki Isshiki, Haruhiko Sato, Yoshiaki Watanabe, Hitoshi Saito, Hiroshi Noda, Tatsuya Tamura, Tomoya Kotake, Toru Esaki
Publikováno v:
Journal of Medicinal Chemistry. 61:5949-5962
During the course of derivatization of HTS hit 4a, we have identified a novel small-molecule hPTHR1 agonist, 1-(3,5-dimethyl-4-(2-((2-((1R,4R)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea (CH544724
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee5e48d9dacf5c4280be8d1ffd84fb9
https://doi.org/10.1021/acs.jmedchem.8b00182
https://doi.org/10.1021/acs.jmedchem.8b00182
Autor:
Ayako Chida‐Nagai, Hiroyuki Akagawa, Saori Sawai, Yue‐Jiao Ma, Satoshi Yakuwa, Jun Muneuchi, Kazushi Yasuda, Hirokuni Yamazawa, Toshiyuki Yamamoto, Emi Takakuwa, Utano Tomaru, Yoshiyuki Furutani, Tatsuya Kato, Gen Harada, Kei Inai, Toshio Nakanishi, Atsushi Manabe, Atsuhito Takeda, Zhi‐Cheng Jing
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Peripheral pulmonary stenosis (PPS) is a condition characterized by the narrowing of the pulmonary arteries, which impairs blood flow to the lung. The mechanisms underlying PPS pathogenesis remain unclear. Thus, the aim of this study was t
Externí odkaz:
https://doaj.org/article/a2cb78169263400cbe224421f099250e
Autor:
Shun Kawai, Kyongsun Pak, Shintaro Iwamoto, Chihiro Kawakami, Ryo Inuzuka, Jun Maeda, Yoshiyuki Furutani, Mitsuhiro Kamisago, Shunichi Takatsuki, Tomomi Uyeda, Hiroyuki Yamagishi, Shuichi Ito, Tohru Kobayashi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 17 (2023)
Background Many prenatal factors are reported to be associated with congenital heart defects (CHD) in offspring. However, these associations have not been adequately examined using large‐scale birth cohorts. Methods and Results We evaluated a data
Externí odkaz:
https://doaj.org/article/0ecc0f09ada4412f87aba87613e3d854
Autor:
Yoshiyuki Furuta, Masatoshi Hikizu, Seiji Wakamatsu, Tokuo Tsuji, Hiroaki Seki, Yosuke Suzuki, Tetsuyou Watanabe
Publikováno v:
The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec). 2018:2P1-A16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcce378801e3341875b5f4a5f2b4064b
https://doi.org/10.1299/jsmermd.2018.2p1-a16
https://doi.org/10.1299/jsmermd.2018.2p1-a16
Publikováno v:
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 64:1934-1938
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a85ff6b4d7d2a8921f0e057ca6c0bb40
https://doi.org/10.3919/jjsa.64.1934
https://doi.org/10.3919/jjsa.64.1934
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:1063-1071
The effects of SK-896, a new human motilin analogue ([Leu13]motilin-Hse), on digestive tract motility in postoperative ileus were evaluated in a dog model of ileus after laparotomy. SK-896 was intravenously administered at 0.17, 0.33 and 0.67 microg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bba014e5857d1cd65dc5897ca322bab
https://doi.org/10.1248/bpb.25.1063
https://doi.org/10.1248/bpb.25.1063
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:528-536
In this study, the feto-placental transfer or excretion into the milk of SK-896 ([Leu13]motilin-Hse), a new human motilin analogue, were assessed after single intravenous injection of gestation or lactating female rats with 3H-SK-896. Two min after i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9ceeaf1742d63ec8cbd6dac620194f4
https://doi.org/10.2133/dmpk.16.528
https://doi.org/10.2133/dmpk.16.528
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:436-444
In this study, the distribution and accumulation of SK-896 ([Leu13]motilin-Hse), a new human motilin analogue, were assessed after single or repeated intravenous administration of rats with3H-SK-896. Following intravenous bolus injection of male rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::887ad1752a0f0b072fd5711aacb05644
https://doi.org/10.2133/dmpk.16.436
https://doi.org/10.2133/dmpk.16.436