Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Yoshiyuki, Hiki"'
Autor:
Ayako Kondo, Kazuo Takahashi, Hisateru Yamaguchi, Yuri Yoshida, Tomohiro Mizuno, Kazuki Nakajima, Hiroki Hayashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Yoshiyuki Hiki, Yukio Yuzawa
Publikováno v:
Fujita Medical Journal, Vol 4, Iss 2, Pp 36-41 (2018)
IgA1 with galactose (Gal)-deficient hinge-region (HR) O-glycans (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), and the serum level of Gd-IgA1 is elevated in the majority of IgAN patients. To characterize the involvement of IgA1 in the developm
Externí odkaz:
https://doaj.org/article/f0fe6c9274a745f0b77c87faa6948544
Autor:
Ayako Kondo, Kazuo Takahashi, Tomohiro Mizuno, Akihiro Kato, Daisuke Hirano, Naoki Yamamoto, Hiroki Hayashi, Shigehisa Koide, Hiroshi Takahashi, Midori Hasegawa, Yoshiyuki Hiki, Shunji Yoshida, Keiji Miura, Yukio Yuzawa
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163085 (2016)
Anti-endothelial cell antibodies (AECA) are frequently detected in patients with systemic lupus erythematosus (SLE), but their pathological role remains unclear. We recently developed a solubilized cell surface protein capture enzyme-linked immunosor
Externí odkaz:
https://doaj.org/article/8147b49e9aa14418841df0a25759d3a6
Autor:
Yuta Saito, Norimi Ohashi, Kazunori Kawaguchi, Yoshiyuki Hiki, Mayuko Mori, Masao Kato, Hiroshi Kawachi, Nobuya Kitaguchi, Midori Hasegawa, Moe Kobayakawa, Yukio Yuzawa, Miwa Sakata
Publikováno v:
Neuropsychiatric Disease and Treatment. 16:607-627
Purpose Amyloid-β protein (Aβ) is one of the causative proteins of Alzheimer's disease. We have been developing extracorporeal blood Aβ-removal systems as a method for enhancing Aβ clearance from the brain. We reported previously that medical ads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7806f8777bc14ffc2d1c41a54a3e69
https://doi.org/10.2147/ndt.s241074
https://doi.org/10.2147/ndt.s241074
Autor:
Kazuyoshi Sakai, Shigeru Nakai, Nobuo Suzuki, Yukio Yuzawa, Masao Kato, Hajime Takechi, Hiroshi Tomizawa, Nobuya Kitaguchi, Yoshiyuki Hiki, Shinji Matsunaga, Hiroko Kushimoto, Kazunori Kawaguchi, Tomoko Kitajima, Harutsugu Tatebe, Takahiko Tokuda, Satoshi Sugiyama, Midori Hasegawa, Masao Mizuno
Publikováno v:
Journal of Alzheimer's Disease. 69:687-707
The accumulation of amyloid-β protein (Aβ) and tau in the brain is a major pathological change related to Alzheimer's disease. We have continued to develop Extracorporeal Blood Aβ Removal Systems (E-BARS) as a method for enhancing Aβ clearance fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907b87a250d35352aace6c654f6f699f
https://doi.org/10.3233/jad-190087
https://doi.org/10.3233/jad-190087
Autor:
Yoshiyuki Hiki, Gen Niimi, Shizuko Nagao, Shigeru Nakai, Hideo Hori, Nobuya Kitaguchi, Masanori Shinzato
Publikováno v:
International Journal of Clinical Medicine. 10:135-149
Background and Objectives: The increasing incidence of patients requiring hemodialysis has become a medical and economic problem globally; it is necessary to maintain renal glomerulus functionality to prevent the progression of chronic kidney disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9715c8d9fd8dded88d36207d4a051513
https://doi.org/10.4236/ijcm.2019.103014
https://doi.org/10.4236/ijcm.2019.103014
Autor:
Kazuo Takahashi, Milan Raska, Milada Stuchlova Horynova, Stacy D Hall, Knud Poulsen, Mogens Kilian, Yoshiyuki Hiki, Yukio Yuzawa, Zina Moldoveanu, Bruce A Julian, Matthew B Renfrow, Jan Novak
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e99026 (2014)
Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc). We have analyzed O-glycosylation
Externí odkaz:
https://doaj.org/article/fb0a5948fb2f4ab5b6bd6ec60773d73b
Autor:
Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao
Publikováno v:
PPAR Research, Vol 2012 (2012)
Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreased cell pr
Externí odkaz:
https://doaj.org/article/90d8d1327d6349b79a6de18f141726c5
Autor:
Ryuji Hata, Makoto Kuroda, Shigeru Nakai, Yoshiyuki Hiki, Masao Kato, Nobuya Kitaguchi, Midori Hasegawa, Masato Abe, Kazuyoshi Sakai, Kazunori Kawaguchi, Yukio Yuzawa, Takao Senda
Publikováno v:
Journal of Alzheimer's Disease. 51:997-1002
As a proof of concept that removal of blood amyloid-β (Aβ) can reduce Aβ deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes Aβ from the blood, were histochemicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11076f9d053a033dc6c368fdd4f024dd
https://doi.org/10.3233/jad-151139
https://doi.org/10.3233/jad-151139
Autor:
Yukio Yuzawa, Midori Hasegawa, Masao Kato, Yuta Saito, Hiroshi Morikawa, Yoshiyuki Hiki, Kazunori Kawaguchi, Norimi Ohashi, Moe Kobayakawa, Miwa Sakata, Nobuya Kitaguchi
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b920cec3620afbe884f226bf87e10c6
https://doi.org/10.1016/j.jalz.2018.06.742
https://doi.org/10.1016/j.jalz.2018.06.742
Autor:
Yoshiyuki Hiki, Yukio Yuzawa, Nobuya Kitaguchi, Shinji Yamada, Akira Saigusa, Midori Hasegawa, Takehiro Gotoh, Kazunori Kawaguchi, Shigeru Nakai
Publikováno v:
Journal of Artificial Organs. 19:149-158
The accumulation of amyloid β protein (Aβ) in the brain reflects cognitive impairment in Alzheimer's disease. We hypothesized that the rapid removal of Aβ from the blood by an extracorporeal system may act as a peripheral Aβ sink from the brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d371bf585ff1d839ed3c2e97e84817b
https://doi.org/10.1007/s10047-015-0878-1
https://doi.org/10.1007/s10047-015-0878-1