Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yoshiyuki, Aratani"'
Autor:
Yoshiyuki Aratani, Hidekazu Matsuya, Koji Yoshida, Masato Higashino, Atsushi Naganawa, Hiroyuki Takeda, Akihiro Kinoshita, Keisuke Hanada, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:200-214
A highly potent and well-balanced dual agonist for the EP2 and EP3 receptors is described. Optimization of the lead compound was accomplished in consideration of the relative agonist activity against each EP subtype receptor and the pharmacokinetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e5a038bf3b1ac9687e5fd070824092
https://doi.org/10.1016/j.bmc.2017.11.035
https://doi.org/10.1016/j.bmc.2017.11.035
Autor:
Hidekazu Matsuya, Yoshiyuki Aratani, Masato Higashino, Akihiro Kinoshita, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1016-1019
The cyclic carbamate derivatives, 2-{[2-((4S)-4-{(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (5) and 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a560699e3534685aede696fd825be5c
https://doi.org/10.1016/j.bmcl.2015.12.039
https://doi.org/10.1016/j.bmcl.2015.12.039
Autor:
Jun Takeuchi, Tetsuya Sekiguchi, Satoshi Itadani, Shinya Takahashi, Naoya Matsumura, Atsuto Inoue, Hiromu Egashira, Yasuo Yonetomi, Yoshisuke Nakayama, Manabu Fujita, Yoshiyuki Aratani, Masaki Ima
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2079-2097
A potent, orally available dual CysLT₁ and CysLT₂ receptor antagonist with a dicarboxylic acid is described. 4-(3-(Carboxymethyl)-4-{(E)-2-[4-(4-phenoxybutoxy)phenyl]vinyl}-1H-indol-1-yl)butanoic acid (15: ONO-4310321, IC₅₀: CysLT₁=13nM, Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f012785de234484c040a0c11cf0c37
https://doi.org/10.1016/j.bmc.2015.03.011
https://doi.org/10.1016/j.bmc.2015.03.011
Autor:
Akihiro, Kinoshita, Masato, Higashino, Koji, Yoshida, Yoshiyuki, Aratani, Akito, Kakuuchi, Keisuke, Hanada, Hiroyuki, Takeda, Atsushi, Naganawa, Hidekazu, Matsuya, Kazuyuki, Ohmoto
Publikováno v:
Bioorganicmedicinal chemistry. 26(1)
A highly potent and well-balanced dual agonist for the EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cecf82fc6035858f7d7798ca4b5c57c2
https://pubmed.ncbi.nlm.nih.gov/29203142
https://pubmed.ncbi.nlm.nih.gov/29203142
Autor:
Yoshisuke Nakayama, Yasuo Yonetomi, Akiharu Ishida, Satoshi Itadani, Akira Imagawa, Hiroaki Nomura, Junya Ueda, Katsuya Hisaichi, Kazuyuki Ohmoto, Masaki Ima, Nobukazu Ohta, Takeshi Nabe, Hiromu Egashira, Atsushi Kinoshita, Tetsuya Kitamine, Michiaki Kadode, Hideki Moriguchi, Manabu Fujita, Yoshiyuki Aratani, Tomohiko Sekioka, Kentaro Yashiro, Yohei Tajima, Yoshiyuki Yamaura, Tetsuya Sekiguchi, Takafumi Nakao, Atsuto Inoue, Naoya Matsumura, Shinya Takahashi, Jun Takeuchi
Publikováno v:
Journal of medicinal chemistry. 58(15)
An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is described. Gemilukast (ONO-6950) was generated via isomerization of the core indole and the incorpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6528ca6d6fa73481e590b5866bf0970a
https://pubmed.ncbi.nlm.nih.gov/26200813
https://pubmed.ncbi.nlm.nih.gov/26200813
Autor:
Satoshi, Itadani, Shinya, Takahashi, Masaki, Ima, Tetsuya, Sekiguchi, Yoshiyuki, Aratani, Hiromu, Egashira, Naoya, Matsumura, Atsuto, Inoue, Yasuo, Yonetomi, Manabu, Fujita, Yoshisuke, Nakayama, Jun, Takeuchi
Publikováno v:
Bioorganicmedicinal chemistry. 23(9)
A potent, orally available dual CysLT₁ and CysLT₂ receptor antagonist with a dicarboxylic acid is described. 4-(3-(Carboxymethyl)-4-{(E)-2-[4-(4-phenoxybutoxy)phenyl]vinyl}-1H-indol-1-yl)butanoic acid (15: ONO-4310321, IC₅₀: CysLT₁=13nM, Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1863169f98c39ed74be52a88cb5e6d5
https://pubmed.ncbi.nlm.nih.gov/25800431
https://pubmed.ncbi.nlm.nih.gov/25800431
Autor:
Takayuki Maruyama, Hisao Nakai, Yoshiyuki Aratani, Toshiaki Matsui, Hiroshi Yamamoto, Masaaki Toda, Masaki Ima, Atsushi Naganawa, Shuichi Ohuchida, Hideomi Kijima, Tetsuji Saito, Masayuki Murota
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:7121-7137
4-{[2-[(2-Furylsulfonyl)(isobutyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoic acid analogs 2a and b and a series of the acid analogs, in which the carboxylic acid residue of 2b was replaced with various kinds of carboxylic acid bioisosteres, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924aaa543d5d62bd691561c027b6431d
https://doi.org/10.1016/j.bmc.2006.06.067
https://doi.org/10.1016/j.bmc.2006.06.067
Autor:
Yoshiyuki Aratani, Hitomi Suzuki, Yoshihiro Matano, Takashi Miyamatsu, Hiroki Kurata, Katsuaki Miyaji, Shigetada Sasako
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2511-2518
The synthesis and properties of some new water-soluble non-ionic triarylbismuthanes are described. o-, m- and p-Tris(methoxymethoxyphenyl)bismuthanes 1a–c are prepared from BiCl3 and the corresponding organolithium or Grignard reagents. Oxidative c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a73561e62847d7d0fb3ca1f9c3c86d7
https://doi.org/10.1039/a803946a
https://doi.org/10.1039/a803946a
Autor:
Satoshi Itadani, Kentaro Yashiro, Yoshiyuki Aratani, Tetsuya Sekiguchi, Atsushi Kinoshita, Hideki Moriguchi, Nobukazu Ohta, Shinya Takahashi, Akiharu Ishida, Yohei Tajima, Katsuya Hisaichi, Masaki Ima, Junya Ueda, Hiromu Egashira, Tomohiko Sekioka, Michiaki Kadode, Yasuo Yonetomi, Takafumi Nakao, Atsuto Inoue, Hiroaki Nomura
Publikováno v:
Journal of Medicinal Chemistry; Aug2015, Vol. 58 Issue 15, p6093-6113, 21p