Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yoshiyasu Fukusumi"'
Autor:
Ying Zhang, Yoshiyasu Fukusumi, Mutsumi Kayaba, Takashi Nakamura, Ryusuke Sakamoto, Naoki Ashizawa, Hiroshi Kawachi
Publikováno v:
Nefrología, Vol 41, Iss 5, Pp 539-547 (2021)
Background: Topiroxostat, an inhibitor of xanthine oxidoreductase (XOR) was shown to reduce urinary albumin excretion of hyperuricemic patients with chronic kidney disease. However, its pharmacological mechanism is not well understood. In this study,
Externí odkaz:
https://doaj.org/article/52deaa41b5124369b4ede2646ddd0ee5
Adaptor protein 14-3-3s have isoform-specific binding partners and roles. We reported 14-3-3β interacts with FKBP12 and synaptopodin to maintain the structure of actin fibers in podocytes. However, differential roles of 14-3-3 isoforms in kidneys ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc62f1283089a580cc0b684bcf7693b0
https://doi.org/10.1101/2023.04.25.538276
https://doi.org/10.1101/2023.04.25.538276
Autor:
Syuhei, Watanabe, Ying, Zhang, Yoshiyasu, Fukusumi, Hidenori, Yasuda, Akira, Takada, Junichiro J, Kazama, Hiroshi, Kawachi
Publikováno v:
American Journal of Nephrology. 53:388-396
Introduction: Thy1.1 glomerulonephritis (Thy1.1 GN) in rats is widely used as an experimental model of mesangial proliferative glomerulonephritis (GN). We previously reported that T-helper (Th) cells were accumulated in glomeruli from the early phase
Autor:
Hiroshi Kawachi, Ryusuke Sakamoto, Ying Zhang, Yoshiyasu Fukusumi, Mutsumi Kayaba, Naoki Ashizawa, Takashi Nakamura
Publikováno v:
Nefrología, Vol 41, Iss 5, Pp 539-547 (2021)
Nefrología (English Edition), Vol 41, Iss 5, Pp 539-547 (2021)
Nefrología (English Edition), Vol 41, Iss 5, Pp 539-547 (2021)
Background: Topiroxostat, an inhibitor of xanthine oxidoreductase (XOR) was shown to reduce urinary albumin excretion of hyperuricemic patients with chronic kidney disease. However, its pharmacological mechanism is not well understood. In this study,
Publikováno v:
The American Journal of Pathology. 191:1209-1226
Ephrin-B1 is one of the critical components of the slit diaphragm of kidney glomerular podocyte. However, the precise function of ephrin-B1 is unclear. To clarify the function of ephrin-B1, ephrin-B1–associated molecules were studied. RNA-sequencin
Publikováno v:
Clinical Journal of Nephrology. :1-6
Proteinuria in several glomerular diseases results from dysfunction of the slit diaphragm, a cell-cell junction of glomerular epithelial cells (podocytes). Ephrin-B1 and its related molecule NHERF 2 are novel essential components of the slit diaphrag
Autor:
Yoshiyasu Fukusumi, Hidenori Yasuda, Ying Zhang, Meiko Kitazawa, Veniamin Ivanov, Hiroshi Kawachi
Publikováno v:
American Journal of Nephrology. 52:620-629
Introduction: Synbindin, originally identified as a neuronal cytoplasmic molecule, was found in glomeruli. The cDNA subtractive hybridization technique showed the mRNA expression of synbindin in glomeruli was downregulated in puromycin aminonucleosid
Autor:
Yoshiyasu Fukusumi, Hiroshi Kawachi
Publikováno v:
Clinical and Experimental Nephrology
Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the development of proteinuria in several glomerular diseases. Slit diaphragm should be a target of a novel therapy for proteinuria. Nephrin, NEPH1, P-cadhe
Publikováno v:
The FASEB Journal. 35
FKBP12 was identified as a binding protein of tacrolimus (Tac). Tac binds to FKBP12 and exhibits immunosuppressive effects in T cells. Although it is reported that Tac treatment directly ameliorates the dysfunction of the podocyte in nephrotic syndro
Publikováno v:
The American journal of pathology. 191(7)
Ephrin-B1 is one of the critical components of the slit diaphragm of kidney glomerular podocyte. However, the precise function of ephrin-B1 is unclear. To clarify the function of ephrin-B1, ephrin-B1-associated molecules were studied. RNA-sequencing