Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yoshiya Amemiya"'
Autor:
Koji Abe, Minoru Uchiyama, Ken Kitayama, Tomiichiro Oda, Yoshiya Amemiya, Tomohiro Nishizawa, Naoko Ubukata, Kenji Wakabayashi, Toshimori Inaba, Makiko Yamada
Publikováno v:
Atherosclerosis. 194:300-308
High-density lipoprotein (HDL) has a protective effect against atherosclerosis. Therefore, a compound that elevates the plasma HDL cholesterol (HDL-C) levels is expected to be a promising anti-atherosclerotic agent. We discovered a novel compound, R-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e252dc324aae98bba6bda98d184880ab
https://doi.org/10.1016/j.atherosclerosis.2006.10.025
https://doi.org/10.1016/j.atherosclerosis.2006.10.025
Autor:
Kenji Wakabayashi, Toshimori Inaba, Koji Abe, Yoshiya Amemiya, Tomiichiro Oda, Tomohiro Nishizawa, Ken Kitayama
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:1629-1638
Recent accumulating evidence supports the concept that raising high-density lipoprotein (HDL) may represent an additional therapeutic target for prevention of cardiovascular disease. Scavenger receptor class B type I plays a critical role in plasma H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b22e3300abab497d578f4a2be2adeef
https://doi.org/10.1211/jpp.58.12.0010
https://doi.org/10.1211/jpp.58.12.0010
Autor:
Youji Furukawa, Masahiro Ikeda, Yasuo Shimoji, Yoshiko Kitahara, Shuichi Miyamoto, Yoshiya Amemiya, Takuro Kanazaki, Toshio Sada, Makoto Mizuno, Hiroyuki Koike, Fujimoto Koichi, Hiroaki Yanagisawa
Publikováno v:
Journal of Medicinal Chemistry. 39:323-338
A series of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds were prepared and evaluated for their antagonistic activities to the angiotensin II (AII) receptor. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4cd3308fb04385c4957345c80d3f42
https://doi.org/10.1021/jm950450f
https://doi.org/10.1021/jm950450f
Autor:
Toshio Sada, Makoto Mizuno, Takuro Kanazaki, Yoshiya Amemiya, Hiroaki Yanagisawa, Fujimoto Koichi, Yasuo Shimoji, Hiroyuki Koike, Yoshiko Fujimoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:177-182
Imidazoles and pyrroles bearing hydroxymethyl and carboxy groups were prepared, and their AII antagonistic activities were evaluated. The hydroxymethyl substituent at the 4 position and the carboxy substituent at the 5 position in the imidazole nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39af18ec745cc676fad6e22880843588
https://doi.org/10.1016/s0960-894x(01)81143-4
https://doi.org/10.1016/s0960-894x(01)81143-4
Publikováno v:
ChemInform. 22
A new and mild method for converting imidazoline derivatives to imidazole derivatives using Pd-C is described. The dehydrogenation of 2-and 2,4-disubstituted imidazolines is carried out in refluxing toluene using Pd-C in good yields. Mixed results ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68525b814a6c248e98994cfbc4c32e53
https://doi.org/10.1002/chin.199112201
https://doi.org/10.1002/chin.199112201
Publikováno v:
Synthetic Communications. 20:2483-2489
A new and mild method for converting imidazoline derivatives to imidazole derivatives using Pd-C is described. The dehydrogenation of 2-and 2,4-disubstituted imidazolines is carried out in refluxing toluene using Pd-C in good yields. Mixed results ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e80265cd0b99c567546f5da1eb1692b
https://doi.org/10.1080/00397919008053197
https://doi.org/10.1080/00397919008053197
Autor:
Burrah V. Venkataraman, Popat N. Patil, Gamal Shams, Karl J. Romstedt, Fu Lian Hsu, Dennis R. Feller, Seoung Soo Hong, Duane D. Miller, Yoshiya Amemiya
Publikováno v:
Journal of medicinal chemistry. 35(4)
Seven analogues of medetomidine and naphazoline were synthesized and evaluated for their alpha 1 (aorta) and alpha 2 (platelet) activities. The analogues were composed of 2- and 4-substituted imidazoles and imidazolines attached through a methylene b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccd6752854ebf7fad2b8ffab0a66317
https://pubmed.ncbi.nlm.nih.gov/1347319
https://pubmed.ncbi.nlm.nih.gov/1347319
Autor:
Duane D. Miller, B.V. Venkataraman, Vimon Tantishaiyakul, Gamal Shams, Popat N. Patil, A. Hamada, Dennis R. Feller, Karl J. Romstedt, Yoshiya Amemiya, F. L. Hsu, J.T. Fashempour
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 344(4)
Potencies of new aromatic substituted fluoro or iodo analogues of catecholimidazolines on functional responses in rat aorta (alpha 1) and platelets (alpha 2) were quantified. (1) When compared either on the basis of EC50 or the dissociation constant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e237adf662a8ccab6cd2949e3e827ef8
https://pubmed.ncbi.nlm.nih.gov/1766472
https://pubmed.ncbi.nlm.nih.gov/1766472
Publikováno v:
NIPPON KAGAKU KAISHI. :762-768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7537a202f459d17336c0f48759e44beb
https://doi.org/10.1246/nikkashi.1981.762
https://doi.org/10.1246/nikkashi.1981.762
Autor:
Hachio Miyazawa, Atsusuke Terada, Takeshi Oshima, Yoshiya Amemiya, Keiichi Matsuda, Naoko Hatakeyama, Kazuyuki Wachi
Publikováno v:
Journal of Medicinal Chemistry. 32:1265-1272
1-Imidazolylalkyl-substituted di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives and related compounds were synthesized from tetrahydrobenzo[b]thiophene derivatives (1 or 4) in order to study the structure-activity relationships of the inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4f30f7365fa78be62958650c6a25dc
https://doi.org/10.1021/jm00126a020
https://doi.org/10.1021/jm00126a020