Výsledky vyhledávání - "Yoshitsugu Shitaka"

Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer’s disease

Autor: Kazumi Kimura, Yoshitsugu Shitaka, Shinya Takami, Katsuya Iuchi, Kiyomi Nishimaki, Takashi Yokota, Takuya Kanamaru, Naomi Kamimura, Shigeo Ohta, Ken-ichiro Katsura, Hiroki Akashiba, Masayuki Ueda, Hyunjin Lee

Publikováno v: Brain Research. 1605:49-58

Stem cell transplantation therapy is currently in clinical trials for the treatment of ischemic stroke, and several beneficial aspects have been reported. Similarly, in Alzheimer’s disease (AD), stem cell therapy is expected to provide an efficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85fd40761ce273b19e980c6bd0f4398
https://doi.org/10.1016/j.brainres.2015.02.011

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Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates

Autor: Junko Yarimizu, Yasuyuki Mitani, Yoshitsugu Shitaka, Keni Ni, Mayuko Okabe, Nobuya Matsuoka, Noritoshi Ishikawa, Makoto Asai, Shingo Yamasaki, Hiroshi Uchino, Kyoko Saita, Takashi Nozawa, Hiroki Akashiba

Publikováno v: Neuropharmacology. 79:412-419

γ-Secretase is the enzyme responsible for the intramembranous proteolysis of various substrates, such as amyloid precursor protein (APP) and Notch. Amyloid-β peptide 42 (Aβ42) is produced through the sequential proteolytic cleavage of APP by β- a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d1326744635f86bf4ff6bfa68ae077
https://doi.org/10.1016/j.neuropharm.2013.12.013

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Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools

Autor: Yasuyuki Mitani, Yoshitsugu Shitaka, Nobuya Matsuoka, Junko Yarimizu, Keni Ni, Hiroki Akashiba

Publikováno v: Journal of Neurochemistry. 125:465-472

Given that amyloid-β 42 (Aβ42) is believed to be a culprit in Alzheimer's disease (AD), reducing Aβ42 production should be a potential therapeutic approach. γ-Secretase modulators (GSMs) cause selective reduction of Aβ42 or both reduction of Aβ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d12a5b1fe356df46ebe12fa41bddfd5
https://doi.org/10.1111/jnc.12125

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Repetitive Closed-Skull Traumatic Brain Injury in Mice Causes Persistent Multifocal Axonal Injury and Microglial Reactivity

Autor: Marilyn A. Levy, Hien T. Tran, Laura Cubells Sánchez, Krikor Dikranian, David L. Brody, Rachel E. Bennett, Yoshitsugu Shitaka

Publikováno v: Journal of Neuropathology & Experimental Neurology. 70:551-567

Repetitive mild or “concussive” traumatic brain injury (TBI) can cause substantial neurological impairment, but the pathology of TBI is not well understood. We report an experimental model of TBI in which the closed skulls of anesthetized male C5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c120fb8458731805dd9c5b18b6976ba
https://doi.org/10.1097/nen.0b013e31821f891f

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Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glutamate Receptor Type 1

Autor: Shigeki Kawabata, Takashi Toya, Yoshitsugu Shitaka, Tomonari Watabiki, Masamichi Okada, Yukinori Nagakura, Atsuyuki Kohara, Seiji Tamura, Satoshi Hayashibe

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 315:163-169

Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders. Here, we describe the radioligand binding properties and pharmacological effects of a newl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294a69d9f941fe1c14aadfce3c5c5375
https://doi.org/10.1124/jpet.105.087171

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Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease

Autor: Kazumi Kimura, Yoshitsugu Shitaka, Katsuya Iuchi, Kiyomi Nishimaki, Shinya Takami, Hiroki Akashiba, Shigeo Ohta, Takuya Kanamaru, Naomi Kamimura, Ken-ichiro Katsura, Takashi Yokota

Publikováno v: Neuroscience letters. 587

Oxidative stress is known to play a prominent role in the onset and early stage progression of Alzheimer's disease (AD). For example, protein oxidation and lipid peroxidation levels are increased in patients with mild cognitive impairment. Here, we c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a61a2b1896896a10ce30f712f281d9
https://pubmed.ncbi.nlm.nih.gov/25529196

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Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice

Autor: Yasuyuki Mitani, Yoshitsugu Shitaka, Hiroshi Uchino, Keni Ni, Junko Yarimizu, Kyoko Saita, Hiroki Akashiba, Nobuya Matsuoka

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(6)

γ-Secretase inhibitors (GSIs) reduce amyloid-β (Aβ) peptides but inevitably increase the β-C-terminal fragment (β-CTF) of amyloid precursor protein (APP), potentially having undesirable effects on synapses. In contrast, γ-secretase modulators (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4862f6ba722365ffd10b683e6b180a2
https://pubmed.ncbi.nlm.nih.gov/22323718

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