Critical Roles of Macrophages in the Formation of Intracranial Aneurysm

Autor: Elena I. Liang, Miyuki Kanematsu, Yoshitsugu Nuki, Chie Kurihara, Michael T. Lawton, Tsung-Ling Tsou, Tomoki Hashimoto, William L. Young, Yoshiteru Tada, Nico van Rooijen, Yasuhisa Kanematsu

Publikováno v: Kanematsu, Y, Kanematsu, M, Kurihara, C, Tada, Y, Tsou, T L, van Rooijen, N, Lawton, M T, Young, W L, Liang, E I, Nuki, Y & Hashimoto, T 2011, ' Critical Roles of Macrophages in the Formation of Intracranial Aneurysm ', Stroke, vol. 42, no. 1, pp. 173-178 . https://doi.org/10.1161/STROKEAHA.110.590976
Stroke, 42(1), 173-178. Lippincott Williams and Wilkins

Background and Purpose— Abnormal vascular remodeling triggered by hemodynamic stresses and inflammation is believed to be a key process in the pathophysiology of intracranial aneurysms. Numerous studies have shown infiltration of inflammatory cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec3b53bc49302e29a426875fd9908ee
https://hdl.handle.net/1871/33269

In vivomicroCT imaging of rodent cerebral vasculature

Autor: Bruce H. Hasegawa, Yoshitsugu Nuki, Youngho Seo, Tomoki Hashimoto

Publikováno v: Physics in Medicine and Biology. 53:N99-N107

Computed tomography (CT) remains a critical diagnostic tool for evaluating patients with cerebrovascular disease, and the advent of specialized systems for imaging rodents has extended these techniques to small animal models of these diseases. We the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7eba234398fa01e0e4079741187917
https://doi.org/10.1088/0031-9155/53/7/n01

Identification of Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2)-Related Small Peptide (H2RSP): Its Nuclear Localization and Generation of Chimeric mRNA Transcribed from both HAI-2 and H2RSP Genes

Autor: Hiroshi Itoh, Masashi Koono, Seiji Naganuma, Hiroaki Kataoka, Yutaka Akiyama, Masamichi Yamauchi, Keiji Miyazawa, Yoshitsugu Nuki, Takeshi Shimomura, Naomi Kitamura

Publikováno v: Biochemical and Biophysical Research Communications. 288:390-399

A novel small gene, designated hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP) was cloned and characterized in the process of the search for splicing variant forms of HAI-2 by 3′-rapid amplification of cDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73bfb8c3921938a47dc6cf6e7db1e9a
https://doi.org/10.1006/bbrc.2001.5767

A mouse model of intracranial aneurysm—technical considerations

Autor: Yoshitsugu Nuki, Yasuhisa Kanematsu, Yoshiteru Tada, Hiroshi Makino, Kosuke Wada, Tomoki Hashimoto, Miyuki Kanematsu, Elena I. Liang

Publikováno v: Intracerebral Hemorrhage Research ISBN: 9783709106921

Intracranial aneurysms can be induced by a single stereotaxic injection of elastase into the cerebrospinal fluid at the right basal cistern in hypertensive mice. This mouse model produces large aneurysm formations with an incidence of 60–80% within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46389afdbda989ee5a6c0d0d50aabf19
https://europepmc.org/articles/PMC3264426/

Roles of macrophages in flow-induced outward vascular remodeling

Autor: Nico van Rooijen, Yoshitsugu Nuki, Eric J. Tsang, William L. Young, Melissa M Matsumoto, Tomoki Hashimoto, Chie Kurihara

Publikováno v: Journal of Cerebral Blood Flow and Metabolism, 29(3), 495-503. Nature Publishing Group
Nuki, Y, Matsumoto, M M, Tsang, E, Young, W L, van Rooijen, N, Kurihara, C & Hashimoto, T 2009, ' Roles of macrophages in flow-induced outward vascular remodeling ', Journal of Cerebral Blood Flow and Metabolism, vol. 29, no. 3, pp. 495-503 . https://doi.org/10.1038/jcbfm.2008.136

Sustained hemodynamic stresses, especially sustained high blood flow, result in flow-induced outward vascular remodeling. Mechanisms that link hemodynamic stresses to vascular remodeling are not well understood. Inflammatory cells, known for their re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c487d3c9fa69dbcf0b09a2114850b
https://pubmed.ncbi.nlm.nih.gov/19002198