Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Yoshitsugu, Aoki"'
Autor:
Masayoshi Otake, Michihiro Imamura, Satoko Enya, Akihisa Kangawa, Masatoshi Shibata, Kinuyo Ozaki, Koichi Kimura, Etsuro Ono, Yoshitsugu Aoki
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Duchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have been used to study the disease, translating findings to humans has been challenging. Micromini
Externí odkaz:
https://doaj.org/article/175119c4150e40bea513c5ea0a05a16b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Human urine-derived cells (UDCs) are primary cultured cells originating from the upper urinary tract and are known to be multipotent. We previously developed MYOD1-transduced UDCs (MYOD1-UDCs) as a model recapitulating the pathogenesis of Du
Externí odkaz:
https://doaj.org/article/e26f4968a67247378f28053aacbd5fe8
Autor:
Fusako Sakai‐Takemura, Fumiaki Saito, Ken'ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Kiichiro Matsumura, Shin'ichi Takeda, Yoshitsugu Aoki, Yuko Miyagoe‐Suzuki
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 11, Pp 453-469 (2023)
Abstract Store‐operated Ca2+ entry (SOCE) is indispensable for intracellular Ca2+ homeostasis in skeletal muscle, and constitutive activation of SOCE causes tubular aggregate myopathy (TAM). To understand the pathogenesis of TAM, we induced pluripo
Externí odkaz:
https://doaj.org/article/9ab6fb4209e344dcab30a52c6893f7f7
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-13 (2023)
Abstract Skeletal muscle comprises different muscle fibers, including slow- and fast-type muscles, and satellite cells (SCs), which exist in individual muscle fibers and possess different myogenic properties. Previously, we reported that myoblasts (M
Externí odkaz:
https://doaj.org/article/24d6a85f204e401197ba4d7fd6519afd
Autor:
Senthilkumar Preethy, Yoshitsugu Aoki, Katsura Minegishi, Masaru Iwasaki, Rajappa Senthilkumar, Samuel J. K. Abraham
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Recent advances in the management of Duchenne muscular dystrophy (DMD), such as exon skipping and gene therapy, though have reached a clinical stage, the outcome at its best is still considered suboptimal. In this study, we evaluated a novel
Externí odkaz:
https://doaj.org/article/23a43cb8b1bd40839261f0f0f32c9f0f
Autor:
Takami Ishizuka, Hirofumi Komaki, Yasuko Asahina, Harumasa Nakamura, Norio Motohashi, Eri Takeshita, Yuko Shimizu‐Motohashi, Akihiko Ishiyama, Chihiro Yonee, Shinsuke Maruyama, Eisuke Hida, Yoshitsugu Aoki
Publikováno v:
Neuropsychopharmacology Reports, Vol 43, Iss 2, Pp 277-286 (2023)
Abstract Aim The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS‐089/NCNP‐02 which can induce exon 44 skipping, in patients with DMD. Additionally, we aimed to identify markers predictive o
Externí odkaz:
https://doaj.org/article/ee15b39e2405482aa4a970d87a49bf53
Autor:
Tsukasa Tominari, Masaru Takatoya, Toshiya Matsubara, Michio Matsunobe, Daichi Arai, Chiho Matsumoto, Michiko Hirata, Shosei Yoshinouchi, Chisato Miyaura, Yoshifumi Itoh, Hirofumi Komaki, Shin’ichi Takeda, Yoshitsugu Aoki, Masaki Inada
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 303 (2023)
Duchenne muscular dystrophy (DMD) is the most common type of neuromuscular disease caused by mutations in the DMD gene encoding dystrophin protein. To quantitively assess human dystrophin protein in muscle biopsy samples, it is imperative to consiste
Externí odkaz:
https://doaj.org/article/763e91c55e694f5ea2261661ed13a96c
Autor:
Mary Chesshyre, Deborah Ridout, Yasumasa Hashimoto, Yoko Ookubo, Silvia Torelli, Kate Maresh, Valeria Ricotti, Lianne Abbott, Vandana Ayyar Gupta, Marion Main, Giulia Ferrari, Anna Kowala, Yung‐Yao Lin, Francesco Saverio Tedesco, Mariacristina Scoto, Giovanni Baranello, Adnan Manzur, Yoshitsugu Aoki, Francesco Muntoni
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1360-1372 (2022)
Abstract Background Duchenne muscular dystrophy (DMD) is caused by DMD mutations leading to dystrophin loss. Full‐length Dp427 is the primary dystrophin isoform expressed in muscle and is also expressed in the central nervous system (CNS). Two shor
Externí odkaz:
https://doaj.org/article/f0e9fb8a39b84e67b80fc0751fc0cab9
Autor:
Alex Zhu, Shuntaro Chiba, Yuki Shimizu, Katsuhiko Kunitake, Yasushi Okuno, Yoshitsugu Aoki, Toshifumi Yokota
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1808 (2023)
Antisense oligonucleotide (ASO)-mediated exon skipping has become a valuable tool for investigating gene function and developing gene therapy. Machine-learning-based computational methods, such as eSkip-Finder, have been developed to predict the effi
Externí odkaz:
https://doaj.org/article/f28c248aea3b4f4b936f9abb21a44cd7
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Approval of therapeutic RNA molecules, including RNA vaccines, has paved the way for next-generation treatment strategies for various diseases. Oligonucleotide-based therapeutics hold particular promise for treating incurable muscular dystrophies, in
Externí odkaz:
https://doaj.org/article/a0505c4e0d714db3bda8fe19aa24e693