Zobrazeno 1 - 10
of 561
pro vyhledávání: '"Yoshito Komatsu"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Trifluridine/tipiracil (FTD/TPI) with or without bevacizumab is an effective treatment for metastatic colorectal cancer (mCRC). As this agent is mainly excreted via the kidney, we aimed to evaluate the impact of renal impairment (RI) on the
Externí odkaz:
https://doaj.org/article/aadfc24014774c979c95a472172d6834
Autor:
Tadayoshi Hashimoto, Yoshiaki Nakamura, Yoshito Komatsu, Satoshi Yuki, Naoki Takahashi, Naohiro Okano, Hidekazu Hirano, Koushiro Ohtsubo, Takashi Ohta, Eiji Oki, Tomohiro Nishina, Hisateru Yasui, Hisato Kawakami, Taito Esaki, Nozomu Machida, Ayako Doi, Shogen Boku, Toshihiro Kudo, Yoshiyuki Yamamoto, Akiyoshi Kanazawa, Tadamichi Denda, Masahiro Goto, Naoko Iida, Hiroshi Ozaki, Taro Shibuki, Mitsuho Imai, Takao Fujisawa, Hideaki Bando, Yoichi Naito, Takayuki Yoshino
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background While advanced gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs), acquired resistance from specific mutations in KIT or PDGFRA frequently occurs. We aimed to assess the utility of
Externí odkaz:
https://doaj.org/article/8d89e02235024fa88d2552871e8438cb
Autor:
Hiroki Osumi, Eiji Shinozaki, Yoshiaki Nakamura, Taito Esaki, Hisateru Yasui, Hiroya Taniguchi, Hironaga Satake, Yu Sunakawa, Yoshito Komatsu, Yoshinori Kagawa, Tadamichi Denda, Manabu Shiozawa, Taroh Satoh, Tomohiro Nishina, Masahiro Goto, Naoki Takahashi, Takeshi Kato, Hideaki Bando, Kensei Yamaguchi, Takayuki Yoshino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract “NeoRAS WT” refers to the loss of RAS mutations (MTs) following first-line treatment in metastatic colorectal cancer (mCRC). We evaluate the incidence and clinicopathological characteristics of NeoRAS WT mCRC using next-generation sequen
Externí odkaz:
https://doaj.org/article/32159db2ff3a4f6f8eaee8f39adf3f96
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Regorafenib is the first multikinase inhibitor for treating metastatic colorectal cancer (mCRC). Proteinuria is a frequently encountered adverse effect, regardless of prior administration of vascular endothelial growth factor inhibitors. Her
Externí odkaz:
https://doaj.org/article/ef8922a606a848b8932d8445f8221a70
Autor:
Yoshito Komatsu, Kei Muro, Masayuki Chosa, Kazufumi Hirano, Toshiyuki Sunaya, Koichi Ayukawa, Kana Hattori, Toshirou Nishida
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundRegorafenib improves overall survival (OS) of patients with advanced progressive gastrointestinal stromal tumors (GISTs) after standard chemotherapy in phase III trials in the 3rd-line setting. This large-scale, prospective observational st
Externí odkaz:
https://doaj.org/article/ce334030a9514926bf9fa62ef7a7dda0
Autor:
Naoto Gotohda, Toshirou Nishida, Shinsuke Sato, Masato Ozaka, Yujiro Nakahara, Yoshito Komatsu, Masato Kondo, Haruhiko Cho, Yukinori Kurokawa, Yuko Kitagawa
Publikováno v:
Annals of Gastroenterological Surgery, Vol 7, Iss 6, Pp 1021-1031 (2023)
Abstract Aim Tumor rupture has been indicated as a risk factor for recurrence of gastrointestinal stromal tumors (GISTs). The universal definition of tumor rupture was proposed. This study evaluated whether the universal definition was more accurate
Externí odkaz:
https://doaj.org/article/af53975c8ac44def88b235c5289ca732
Autor:
Kazuaki Harada, Satoshi Yuki, Yasuyuki Kawamoto, Takeaki Nakamura, Shiho Kaneko, Koichi Ishida, Naoya Sakamoto, Yoshito Komatsu
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
The Neo RAS phenomenon is defined as the conversion of tumor RAS status from mutant-type (MT) to wild-type (WT) after systemic chemotherapy in metastatic colorectal cancer (mCRC). Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, i
Externí odkaz:
https://doaj.org/article/bf4161cd18b7424d8bb1908e51b8f720
Autor:
Kensuke Sakurai, Takehiko Katsurada, Mutsumi Nishida, Satomi Omotehara, Shinya Fukushima, Shinsuke Otagiri, Kazunori Nagashima, Reizo Onishi, Ryo Takagi, Yoshito Komatsu, Naoya Sakamoto
Publikováno v:
Intestinal Research, Vol 21, Iss 1, Pp 126-136 (2023)
Background/Aims The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event indu
Externí odkaz:
https://doaj.org/article/c549f34fa4794a3e83009593d85eaa84
Autor:
Michio Nakamura, Atsushi Ishiguro, Masayoshi Dazai, Yasuyuki Kawamoto, Satoshi Yuki, Susumu Sogabe, Ayumu Hosokawa, Kentaro Sawada, Osamu Muto, Naoki Izawa, Koji Nakashima, Yoshiki Horie, Masataka Yagisawa, Shinya Kajiura, Takayuki Ando, Yosuke Mitsuhashi, Yu Sunakawa, Yasuka Kikuchi, Yoshito Komatsu
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Although initial therapy with a parenteral anticoagulant is required before edoxaban, this strategy is frequently avoided in actual clinical practice because of its complexity. This study assessed the feasibility of edoxaban witho
Externí odkaz:
https://doaj.org/article/920bd0892d904f39b7d402794cf1198e
Autor:
Kazutaka Yamada, Yasumitsu Saiki, Koji Komori, Akio Shiomi, Masashi Ueno, Masaaki Ito, Koya Hida, Seiichiro Yamamoto, Manabu Shiozawa, Soichiro Ishihara, Yukihide Kanemitsu, Hideki Ueno, Tatsuya Kinjo, Kotaro Maeda, Junichiro Kawamura, Fumihiko Fujita, Keiichi Takahashi, Tsunekazu Mizushima, Yasuhiro Shimada, Shin Sasaki, Eiji Sunami, Fumio Ishida, Keiji Hirata, Shinobu Ohnuma, Kimihiko Funahashi, Jun Watanabe, Yusuke Kinugasa, Shigeki Yamaguchi, Yojiro Hashiguchi, Masataka Ikeda, Takeshi Sudo, Yoshito Komatsu, Keiji Koda, Kazuhiro Sakamoto, Masazumi Okajima, Hideyuki Ishida, Yuichi Hisamatsu, Taiki Masuda, Shinichiro Mori, Kazuhito Minami, Seiji Hasegawa, Shungo Endo, Akinori Iwashita, Madoka Hamada, Yoichi Ajioka, Koichiro Usuku, Tokunori Ikeda, Kenichi Sugihara
Publikováno v:
Cancer Medicine, Vol 11, Iss 14, Pp 2735-2743 (2022)
Abstract Anal canal cancer (ACC) has been reported to be an uncommon cancer in Japan, as in the USA, Europe, and Australia. This retrospective multi‐institutional study was conducted to clarify the characteristics of ACC in Japan. First, the histol
Externí odkaz:
https://doaj.org/article/8d46538318c1400a871ddb740e9e60b2