Zobrazeno 1 - 10
of 460
pro vyhledávání: '"Yoshito Kishi"'
Autor:
Junichiro En, Sho Kitamoto, Akira Kawashima, Suguru Yonezawa, Yoshito Kishi, Norihisa Ishii, Masamichi Goto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005834 (2017)
Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to
Externí odkaz:
https://doaj.org/article/361bc656c9f5454c94ff3f757c0d60ee
Autor:
Anita Wadagni, Michael Frimpong, Delphin Mavinga Phanzu, Anthony Ablordey, Emmanuel Kacou, Mirabelle Gbedevi, Estelle Marion, Yalan Xing, Vaddela Sudheer Babu, Richard Odame Phillips, Mark Wansbrough-Jones, Yoshito Kishi, Kingsley Asiedu
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 11, p e0004247 (2015)
INTRODUCTION:Mycobacterium ulcerans infection, known as Buruli ulcer, is a disease of the skin and subcutaneous tissues which is an important but neglected tropical disease with its major impact in rural parts of West and Central Africa where facilit
Externí odkaz:
https://doaj.org/article/14b3c5d366934cf4bb564d7a0e1cd9d9
Autor:
Paul J Converse, Sandeep Tyagi, Yalan Xing, Si-Yang Li, Yoshito Kishi, John Adamson, Eric L Nuermberger, Jacques H Grosset
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003823 (2015)
Treatment of Buruli ulcer, or Mycobacterium ulcerans disease, has shifted from surgical excision and skin grafting to antibiotic therapy usually with 8 weeks of daily rifampin (RIF) and streptomycin (STR). Although the results have been highly favora
Externí odkaz:
https://doaj.org/article/d3a1fd958498456cba69bdab155369a4
Autor:
Paul J Converse, Yalan Xing, Ki Hyun Kim, Sandeep Tyagi, Si-Yang Li, Deepak V Almeida, Eric L Nuermberger, Jacques H Grosset, Yoshito Kishi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2618 (2014)
Diagnosis of the neglected tropical disease, Buruli ulcer, can be made by acid-fast smear microscopy, specimen culture on mycobacterial growth media, polymerase chain reaction (PCR), and/or histopathology. All have drawbacks, including non-specificit
Externí odkaz:
https://doaj.org/article/7dcad3d1367940f4945947cb576dfb05
Autor:
Bruce A. Littlefield, Melvin J. Yu, Yoshito Kishi, Bryan M. Lewis, Xiaojie Zhu, Boris M. Seletsky, Wanjun Zheng, Kimberley K. Aalfs, Bruce F. Wels, Kathleen A. Salvato, Murray J. Towle
Supplementary Figures S1-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca24a570431d08fbc8d5c6fc05689ec0
https://doi.org/10.1158/0008-5472.22385954.v1
https://doi.org/10.1158/0008-5472.22385954.v1
Autor:
Vemula Praveen Kumar, Yoshito Kishi
Publikováno v:
Journal of the American Chemical Society. 142:14743-14749
The first total synthesis of halistatins 1 and 2 has been completed using Cr-mediated coupling reactions for the C11/C12, C17/C18, and C19/C20 bond formation. For the C11/C12 bond formation, a stoichiometric Ni/Cr-mediated reaction is used to couple
Autor:
Takanori Abe, Satoshi Kawano, Ken Ito, Taro Semba, Kimiyo Tabata, Hiroki Jozawa, Osamu Asano, Yoshito Kishi
Publikováno v:
Cancer Research. 82:1865-1865
Introduction and objectives: E7130 is a novel anti-cancer agent created from a total synthetic study of the natural compound norhalichondrin B, and is evaluated in a clinical study currently (NCT03444701). Previous pre-clinical study reported that E7
Autor:
Yuki Sato, Ken Ito, Yoshito Kishi, Takashi Fukuyama, Takeo Sasaki, Isao Ohashi, Kentaro Iso, Takanori Abe, Tsuyoshi Akagi, Kenzo Yahata, Minetaka Isomura, Makoto Asano, Yosuke Kaburagi, Yasunobu Matsumoto, Fumiyoshi Matsuura, Yusuke Miyashita, Takashi Owa, Satoshi Kawano, Kazunobu Kira, Akira Yokoi, Osamu Asano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Despite their outstanding antitumour activity in mice, the limited supply from the natural sources has prevented drug discovery/development based on intact halichondrins. We achieved a total synthesis of C52-halichondrin-B amine (E7130) on a >10 g sc
Publikováno v:
Angewandte Chemie. 129:10931-10935
A zirconium/nickel-mediated one-pot synthesis of ketones is reported. In the presence of Zn or Mn, Cp2 ZrCl2 was found to dramatically accelerate the coupling and suppress side product formation via an I→SPy displacement at the same time. Unlike Zn