Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Yoshito, Kumagai"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract A previous study by our group indicated that methylmercury (MeHg) is biotransformed to bismethylmercury sulfide [(MeHg)2S)] by interaction with reactive sulfur species (RSS) produced in the body. In the present study, we explored the transfo
Externí odkaz:
https://doaj.org/article/9ff19bce70354b1192b4c04562513d22
Autor:
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102514- (2022)
Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-ly
Externí odkaz:
https://doaj.org/article/ef3f1e3c976a479486f613b7e183028e
Autor:
Kensuke Sato, Ryota Nakano, Yoshitaka Yamazaki, Hikaru Isobe, Yun-Gi Kim, Masahiro Hosonuma, Masahiro Akiyama, Yoshito Kumagai
Publikováno v:
Fundamental Toxicological Sciences; 2024, Vol. 11 Issue 3, p131-139, 9p
Publikováno v:
Fundamental Toxicological Sciences; 2024, Vol. 11 Issue 2, p79-85, 7p
Autor:
Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9982 (2023)
Cystathionine γ-lyase (CSE) is an enzyme responsible for the biosynthesis of cysteine from cystathionine in the final step of the transsulfuration pathway. It also has β-lyase activity toward cystine, generating cysteine persulfide (Cys-SSH). The c
Externí odkaz:
https://doaj.org/article/75198ecd49074b038111f2ea4ea8155b
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110479- (2022)
Summary: Gut microbiota act beyond the gastrointestinal tract to regulate the physiology of the host. However, their contribution to the antioxidant capacity of the host remains largely understudied. In this study, we observe that gut bacteria increa
Externí odkaz:
https://doaj.org/article/acc81ace6dae46ac94df7d9756622bfb
Autor:
Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15412 (2022)
Methylmercury (MeHg), an environmental toxicant, induces neuronal cell death and injures specific areas of the brain. MeHg is known to induce oxidative and endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) pathway has a dual natu
Externí odkaz:
https://doaj.org/article/c92902097e504351975503f7266561eb
Autor:
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3201 (2022)
GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that Gcn1 mutant mice lacking the GCN2-binding domain suffer from growt
Externí odkaz:
https://doaj.org/article/8e518720faf048c0ba956cdf00949372
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:338-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::162611b1040728061aecce3c9db2f37c
https://doi.org/10.1248/bpb.b22-00543
https://doi.org/10.1248/bpb.b22-00543
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:334-337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::097083b95de5a1cfe9f2ba47f58ec38a
https://doi.org/10.1248/bpb.b22-00531
https://doi.org/10.1248/bpb.b22-00531