Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Yoshitake, Nishimune"'
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9060
HASPIN is predominantly expressed in spermatids, and plays an important role in cell division in somatic and meiotic cells through histone H3 phosphorylation. The literature published to date has suggested that HASPIN may play multiple roles in cells
Autor:
Junji Tsuchida, Morimasa Wada, Yoshifumi Kawamura, Masahito Ikawa, Hidenobu Okuda, Kei Yamaguchi, Virginia Smith Shapiro, Naoki Goshima, Shinichiro Fukuhara, Akira Tsujimura, Yoshitake Nishimune, Mieko Takasaka, Yoshitaka Kawakami, Eriko Fukuda, Hiromitsu Tanaka, Yasushi Miyagawa, Yuki Okada, Ayako Isotani
Publikováno v:
Genes to Cells. 26:180-189
TRA98 is a rat monoclonal antibody (mAb) which recognizes a specific antigen in the nuclei of germ cells. mAb TRA98 has been used to understand the mechanism of germ cell development and differentiation in many studies. In mice, the antigen recognize
Autor:
Morimasa Wada, Kazuhiro Kaseda, Yusuke Aoki, Hidenobu Okuda, Shigeo Horie, Moira K O'Bryan, Hiromitsu Tanaka, Yoshitake Nishimune, Keizo Tokuhiro, Kouichi Kitamura, Tomoe Ohta, Tsukasa Fujiki, Akira Tsujimura, Yukiko Ogawa, Masaru Okabe
Publikováno v:
Molecular reproduction and developmentREFERENCES. 87(5)
Haprin (TRIM36) is a ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. It is expressed in the testes in both mice and humans and is thought to be involved in spermiogenesis, the acrosome
Autor:
Keizo Tokuhiro, Ayako Isotani, Sadaki Yokota, Yoshihisa Yano, Shigeru Oshio, Mika Hirose, Morimasa Wada, Kyoko Fujita, Yukiko Ogawa, Masaru Okabe, Yoshitake Nishimune, Hiromitsu Tanaka
Publikováno v:
PLoS Genetics, Vol 5, Iss 11, p e1000712 (2009)
Polyamines are known to play important roles in the proliferation and differentiation of many types of cells. Although considerable amounts of polyamines are synthesized and stored in the testes, their roles remain unknown. Ornithine decarboxylase an
Externí odkaz:
https://doaj.org/article/6738a59ffb7e422eb3895f608bbbe737
Autor:
Hiromitsu Tanaka, Yoshitake Nishimune, Akira Tsujimura, Damin Choi, Hiromi Nishimura, Yasushi Miyagawa, Morimasa Wada, Dakyo Oh
Publikováno v:
Advances in Sexual Medicine. :19-25
HASPIN is a serine/threonine protein kinase predominantly expressed during spermatogenesis and localized in the nucleus. The HASPIN gene is conserved from yeast to mammals and plants. To investigate any possible associations between HASPIN polymorphi
Autor:
Masakazu Umezawa, Hikari Takahashi, Yoshitake Nishimune, Hitoshi Tainaka, Hiromitsu Tanaka, Ken Takeda, Shigeru Oshio
Publikováno v:
The Journal of Toxicological Sciences. 37:539-548
Bisphenol A (BPA) is known to be an endocrine disruptor that affects the development of reproductive system. The aim of the present study was to investigate a group of testicular genes dysregulated by prenatal exposure to BPA. Pregnant ICR mice were
Autor:
Yoshitake Nishimune, Hikari Takahashi, Hiromitsu Tanaka, Ken Takeda, Hitoshi Tainaka, Masakazu Umezawa, Shigeru Oshio
Publikováno v:
The Journal of Toxicological Sciences. 36:559-567
Testicular toxicity of chemical substances has been generally assessed by sperm properties and histology. However, the methods can provide only a few information of the mechanism of the toxicity. The aim of this study is to show a method that can eva
Autor:
Akira Tsujimura, Mika Hirose, Ken Takeda, Kiyotaka Toshimori, Shigeru Oshio, Hitoshi Tainaka, Ayako Isotani, Akihiko Okuyama, Yoshitake Nishimune, Masaru Okabe, Junji Tsuchida, Hiromitsu Tanaka, Shinji Irie, Yasushi Miyagawa, Chizuru Ito, Yoshiro Toyama, Keizo Tokuhiro
Publikováno v:
Journal of Biological Chemistry. 283:19039-19048
Meichroacidin (MCA) is a highly hydrophilic protein that contains the membrane occupation and recognition nexus motif. MCA is expressed during the stages of spermatogenesis from pachytene spermatocytes to mature sperm development and is localized in
Autor:
Akira Tsujimura, Yasushi Miyagawa, Tohru Takahashi, Keizo Tokuhiro, Kiyomi Matsumiya, Hiromitsu Tanaka, Yoshitake Nishimune, Kouichi Kitamura, Naoko Iguchi, Yasuhiro Matsuoka, Mamiko Maekawa, Akihiko Okuyama
Publikováno v:
Molecular Reproduction and Development. 75:967-975
The manchette, which is the structure that appears around the nuclei of elongated spermatids, is assumed to be involved in nuclear shaping during spermiogenesis and the transport of various proteins between the nucleus and sperm tail. In this report,
Publikováno v:
International Journal of Andrology. 30:462-475
Summary The comprehensive changes in testicular gene expression before and after haploid germ cell differentiation were examined using microarray analysis. Approximately 14 000 expressed sequence tag (EST) clones of Mouse FANTOM Array ver.1 were hybr