Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yoshitaka Umetsu"'
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 2, Pp 1-21 (2021)
Abstract The development of eukaryote‐derived antimicrobial peptides as systemically administered drugs has proven a challenging task. Here, we report the first human oral actinomyces‐sourced defensin—actinomycesin—that shows promise for syst
Externí odkaz:
https://doaj.org/article/a49a93f8b62d4e539800430463584f0a
Accidental Interaction between PDZ Domains and Diclofenac Revealed by NMR-Assisted Virtual Screening
Autor:
Kengo Kinoshita, Hidekazu Hiroaki, Motonori Ota, Takeshi Tenno, Natsuko Goda, Yoshitaka Umetsu
Publikováno v:
Molecules, Vol 18, Iss 8, Pp 9567-9581 (2013)
In silico approaches have become indispensable for drug discovery as well as drug repositioning and adverse effect prediction. We have developed the eF-seek program to predict protein–ligand interactions based on the surface structure of proteins u
Externí odkaz:
https://doaj.org/article/26508683e3a9481c93079ae84d34b809
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 2, Pp n/a-n/a (2022)
The development of eukaryote-derived antimicrobial peptides as systemically administered drugs has proven a challenging task. Here, we report the first human oral actinomyces-sourced defensin-actinomycesin-that shows promise for systemic therapy. Act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646c70470466616a7f72d021dfbef3c6
https://doaj.org/article/a49a93f8b62d4e539800430463584f0a
https://doaj.org/article/a49a93f8b62d4e539800430463584f0a
Publikováno v:
TAP CHI SINH HOC. 39:309-319
In our previous study, functional ability and conformational stability had been examined for C-terminal deletion mutants of a 148-residue Ca2+-binding protein, chicken calmodulin (CaM). In that study, we had reported that a mutant named CCMΔ5, missi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730dd96cd07c68335096332155020d6a
https://doi.org/10.15625/0866-7160/v39n3.10111
https://doi.org/10.15625/0866-7160/v39n3.10111
Publikováno v:
Molecular Biology and Evolution. 31:546-559
Scorpion K(+) channel toxins and insect defensins share a conserved three-dimensional structure and related biological activities (defense against competitors or invasive microbes by disrupting their membrane functions), which provides an ideal syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b3032cd5a9cb830d7a7d8fc0faf691
https://doi.org/10.1093/molbev/msu038
https://doi.org/10.1093/molbev/msu038
Publikováno v:
Journal of Structural and Functional Genomics. 12:167-174
Assignment of backbone amide proton resonances is one of the most time-consuming stages of any protein NMR study when the protein samples behave non-ideally. A robust and convenient NMR procedure for analyzing spectra of marginal-to-low quality is he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fd4ad3c40025fe08a58b3e3e7b2727
https://doi.org/10.1007/s10969-011-9116-0
https://doi.org/10.1007/s10969-011-9116-0
Autor:
Natsuko Goda, Takahisa Ikegami, Yoshitaka Umetsu, Takeshi Tenno, Masahiro Shirakawa, Hidekazu Hiroaki
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1814:724-730
Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide which belongs to a glucagon/secretin superfamily, the ligand of class II G protein-coupled receptors. Knowledge for the conformation of VIP bound to membrane is important because the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e0e906546acbfb5bd62894364bb347
https://doi.org/10.1016/j.bbapap.2011.03.009
https://doi.org/10.1016/j.bbapap.2011.03.009
Autor:
Tatsuya Sawasaki, Shin-ichi Muramatsu, Hitomi Komura, Yu Nakamura, Yo-ichi Nabeshima, Minako Hoshi, Yoshiki Shigemitsu, Takayuki Ohnishi, Genji Iwasaki, Hiroyuki Takeda, Ko Matsui, Masako Yanazawa, David B. Teplow, Hitoshi Takahashi, Masafumi Inoue, Akiyoshi Kakita, Isao Kii, Yoshitaka Umetsu, Yasuki Kitamura, Satoko Sakai, Yoshie Arai, Natsuko Goda, Akihide Takeuchi, Michio Sato, Hidekazu Hiroaki, Tomoya Sasahara, Akane Ito, Kaori Satomura, Yugo Fukazawa, Mari Tada, Masatoshi Hagiwara, Hajime Hirao, Takashi Nishiyama, Naomi Takino, Eri Saijo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 32
Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b4cf7189fb3114290ea7d09741ef5e
https://doi.org/10.1073/pnas.1421182112
https://doi.org/10.1073/pnas.1421182112
Autor:
Natsuko Goda, Naoko Iwaya, Yohta Kuwahara, Hidekazu Hiroaki, Yoshitaka Umetsu, Tomoyuki Tsuruta
Publikováno v:
Biomolecular NMR Assignments. 6:23-25
Stomatin, a 288-residue protein, is a component of the membrane skeleton of red blood cells (RBCs), which helps to physically support the membrane and maintains its function. In RBCs, stomatin binds to the glucose transporter GLUT-1 and may regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fdbe0fd99ce93356b2f097d36fba418
https://doi.org/10.1007/s12104-011-9317-2
https://doi.org/10.1007/s12104-011-9317-2
Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter
Publikováno v:
Biochemical pharmacology. 93(2)
Venom-derived neurotoxins are ideal probes for the investigation of structure-function relationship of ion channels and promising scaffolds for the design of ion channel-targeted drug leads as well. The discovery of highly selective toxins against a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9378d5649d9dbdb1ba1251e9c4055850
https://pubmed.ncbi.nlm.nih.gov/25514171
https://pubmed.ncbi.nlm.nih.gov/25514171