Výsledky vyhledávání - "Yoshitaka Nishita"

Design and synthesis of novel metalloproteinase inhibitors

Autor: Masahiro Ikura, Tsuneyuki Sugiura, Shingo Nakatani, Shingo Yamamoto, Satoshi Itadani, Hiroyuki Ohno, Yoshitaka Nishita, Hiromu Habashita, Masaaki Toda, Kanji Takahashi, Koji Ogawa, Hisao Nakai

Publikováno v: Bioorganic & Medicinal Chemistry. 14:5402-5422

A series of N-benzoyl 4-aminobutyric acid hydroxamate analogs were synthesized and evaluated as matrix metalloproteinase inhibitors. Synthetic work was focused on the chemical modification of the 4-aminobutyric acid part using easily available starti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551385e62e39b48e1a4bcf1c126af91e
https://doi.org/10.1016/j.bmc.2006.03.032

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Highly potent inhibitors of tnf-α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Autor: Wataru Kamoshima, Takaaki Obata, Shuichi Nakazawa, Akihito Ogata, Hideaki Mori, Takashi Kondo, Hisao Nakai, Masaaki Toda, Setsuko Fujita, Kouichiro Terai, Satoshi Itadani, Yoshitaka Nishita, Hiroyuki Ohno, Nagashige Omawari, Toshiaki Matsui, Masaru Sakai, Hiroshi Tsuruta

Publikováno v: Bioorganic & Medicinal Chemistry. 10:3787-3805

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76cf58d7c7613fc625075b7fc98600
https://doi.org/10.1016/s0968-0896(02)00380-2

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Highly potent inhibitors of TNF-α production. Part I

Autor: Akihito Ogata, Shuichi Nakazawa, Masaaki Toda, Masaru Sakai, Takaaki Obata, Shingo Nakatani, Takashi Kondo, Nagashige Omawari, Wataru Kamoshima, Toshiaki Matsui, Yoshitaka Nishita, Kouichiro Terai, Satoshi Itadani, Hideaki Mori, Hisao Nakai, Hiroyuki Ohno

Publikováno v: Bioorganic & Medicinal Chemistry. 10:3757-3786

Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04590084d29770666fa5f653938f0042
https://doi.org/10.1016/s0968-0896(02)00381-4

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Baeyer-Villiger Reaction of Benzaldehydes Possessing Oxygen Functions with SeO2-H2O2

Autor: Keiko Katsuno, Masako Fujii, Takashi Harayama, Yoshitaka Nishita, Hiromi Nishioka, Natsuko Koshiba

Publikováno v: YAKUGAKU ZASSHI. 119:519-528

The Baeyer-Villiger (B. V.) reaction using SeO2-H2O2 was examined for various benzaldehydes possessing methoxy groups and/or a furan ring. When benzaldehydes have an electron-donating group (methoxy group) at the ortho or para position to a formyl gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2e0036b6102bddfc5e1a2800a6b06e
https://doi.org/10.1248/yakushi1947.119.7_519

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Highly Potent Inhibitors of TNF-α Production. Part 1: Discovery of Chemical Leads

Autor: Masaru Sakai, Takaaki Obata, Akihito Ogata, Yoshitaka Nishita, Shingo Nakatani, Hisao Nakai, Hiroyuki Ohno, Masaaki Toda, Nagashige Omawari, Toshiaki Matsui, Shuichi Nakazawa, Takashi Kondo, Satoshi Itadani

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:903-905

The discovery of 2-acylamino-2-phenylethyl disodium phosphates 1 and 2 as structurally novel inhibitors of TNF-α production is reported. Structure–activity relationships (SARs) are also discussed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abadf1b52084c0f9fe6c16cdfc9a2561
https://doi.org/10.1016/s0960-894x(02)00036-7

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Design and synthesis of an orally active matrix metalloproteinase inhibitor

Autor: Shingo Nakatani, Hisao Nakai, Satoshi Itadani, Masaaki Toda, Masahiro Ikura, Kanji Takahashi, Yoshitaka Nishita, Tsuneyuki Sugiura, Shingo Yamamoto, Koji Ogawa, Hiroyuki Ohno

Publikováno v: Bioorganicmedicinal chemistry. 14(18)

A series of 4-(4-phenoxy)benzoylamino-4-methoxymethyloxymethyl butyric acid hydroxamates, which were derived from l-glutamic acid, were synthesized and evaluated as matrix metalloproteinase inhibitors. Most of the compounds listed in exhibited strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1442ff38d5581d18026a2c7b56c3e38
https://pubmed.ncbi.nlm.nih.gov/16765051

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