Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yoshitaka J Sei"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102617- (2023)
Summary: Spatial transcriptomics couples visual spatial markers with gene expression levels, but slide space and cost limit the number of samples that can be processed. Here, we present a protocol for mounting brains from multiple mice onto a single
Externí odkaz:
https://doaj.org/article/56352c5e10d7453cb51866560d92cb06
Autor:
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112335- (2023)
Summary: Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we show that human neurons do metabolize glucose through glycolysis and can rely o
Externí odkaz:
https://doaj.org/article/5e1e130f24524f59b205438e36d2ce00
Autor:
Song Ih Ahn, Yoshitaka J. Sei, Hyun-Ji Park, Jinhwan Kim, Yujung Ryu, Jeongmoon J. Choi, Hak-Joon Sung, Tobey J. MacDonald, Allan I. Levey, YongTae Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Developing an in vitro blood-brain-barrier (BBB) model that reproduces the organ’s complex structure and function is an open challenge. Here the authors present a BBB-on-a-chip that includes endothelial cells, pericytes and a 3D astrocytic network
Externí odkaz:
https://doaj.org/article/95fd2b9d6594462fac69a3cba4e9f50b
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::906c23dfb0646c39fdb842ec604544f1
https://doi.org/10.1002/alz.060763
https://doi.org/10.1002/alz.060763
Autor:
Hyun Ji Park, Allan I. Levey, Jinhwan Kim, Yujung Ryu, Song Ih Ahn, Jeongmoon J. Choi, Hak-Joon Sung, Tobey J. MacDonald, Yoshitaka J. Sei, YongTae Kim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Challenges in drug development of neurological diseases remain mainly ascribed to the blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug discovery, it remains difficult to conduct mechanistic studies on the barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c9f3c293203870ac373a277da4a8da
http://link.springer.com/article/10.1038/s41467-019-13896-7
http://link.springer.com/article/10.1038/s41467-019-13896-7
Publikováno v:
Bioengineering, Vol 4, Iss 3, p 64 (2017)
Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target
Externí odkaz:
https://doaj.org/article/6cb53745e2674eeda5d10ce5f24b4453
Autor:
YongTae Kim, Anna Kenney, Yoshitaka J. Sei, Tobey J. MacDonald, Jinhwan Kim, Song Ih Ahn, Anshu Malhotra, Jingbo Liu, Abhinav Dey
Publikováno v:
Proc Natl Acad Sci U S A
The sonic hedgehog subtype of medulloblastoma (SHH MB) is associated with treatment failure and poor outcome. Current strategies utilizing whole brain radiation therapy result in deleterious off-target effects on the normal developing childhood brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adde39d12bdb15e43393b21ea1416c16
https://europepmc.org/articles/PMC7533889/
https://europepmc.org/articles/PMC7533889/
Autor:
Hyun Ji Park, Jin You, Hyeon-Ki Jang, Dan Bi Park, Seong-Deok Lee, Yoshitaka J. Sei, YongTae Kim, Se Won Yi, Young Min Shin, Sewoom Baek, Chang-Soo Kim, Jung Bok Lee, Song Ih Ahn, Hye-Seon Kim, Hak-Joon Sung, Jeong-Kee Yoon, Dae Hyun Kim, Sangsu Bae, Mi-Lan Kang
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 16(16)
Atherosclerosis development leads to irreversible cascades, highlighting the unmet need for improved methods of early diagnosis and prevention. Disturbed flow formation is one of the earliest atherogenic events, resulting in increased endothelial per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56f34e35804da72a70390998964c84d
https://pubmed.ncbi.nlm.nih.gov/32239653
https://pubmed.ncbi.nlm.nih.gov/32239653
Autor:
Taeyoung Kim, Angel J. Santiago-Lopez, YongTae Kim, Noo Li Jeon, Seung Soon Jang, Yoshitaka J. Sei, Jungho Ahn, Eunjung Shin, Young C. Jang
Publikováno v:
Biomaterials. 170:58-69
High-density lipoprotein (HDL) is a key regulator of lipid homeostasis through its native roles like reverse cholesterol transport. The reconstitution of this natural nanoparticle (NP) has become a nexus between nanomedicine and multi-disease therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa73b02fbff192386955f10c7f5243c
https://doi.org/10.1016/j.biomaterials.2018.04.011
https://doi.org/10.1016/j.biomaterials.2018.04.011
Publikováno v:
IEEE Transactions on Nanotechnology. 17:393-397
High-density lipoproteins (HDL) are known to contribute to vascular homeostasis, but recent HDL-mimetic therapies attempting to capitalize on the vasculoprotective properties associated with HDL have been met with roadblocks in their translational jo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d54ae017ac226f1236350d16229c5b4
https://doi.org/10.1109/tnano.2017.2771426
https://doi.org/10.1109/tnano.2017.2771426