Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Yoshitaka Hosokawa"'
Autor:
Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Mrityunjoy Biswas, Toshinori Hyodo, Hideaki Ito, Atsushi Suzuki, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa, Akiyoshi Takami
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract 5′ adenosine monophosphate–activated protein kinase–related kinase 5 (ARK5) is involved in mitochondrial ATP production and associated with poor prognosis of multiple myeloma (MM). However, the molecular mechanisms of ARK5 in MM remain
Externí odkaz:
https://doaj.org/article/c8c4f6b7fa1a404da2825b786d04fd7b
Autor:
Maho Onda, Akinobu Ota, Kunihiro Ito, Takayuki Ono, Sivasundaram Karnan, Mikako Kato, Sayuri Kondo, Akifumi Furuhashi, Tomio Hayashi, Yoshitaka Hosokawa, Yoshiaki Kazaoka
Publikováno v:
Cancer Medicine, Vol 12, Iss 15, Pp 16416-16430 (2023)
Abstract Background Epidermal growth factor receptor (EGFR) is frequently overexpressed in oral squamous cell carcinoma (OSCC), and EGFR‐targeting therapeutics have been widely employed to treat patients with a variety of carcinomas including OSCC.
Externí odkaz:
https://doaj.org/article/433d6e8a4dd6488eab98ec1b965f732e
Autor:
Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md. Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Lam Quang Vu, Ichiro Hanamura, Akihito Inoko, Miho Riku, Hideaki Ito, Yoshifumi Kaneko, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Malignant mesothelioma (MMe) is a rare but aggressive malignancy. Although the molecular genetics of MMe is known, including BRCA1-associated protein-1 (BAP1) gene alterations, the prognosis of MMe patients remains poor. Here, we generated B
Externí odkaz:
https://doaj.org/article/ec1ed1cefb4f43d0a333234d3c0668cd
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 7, Pp 2915-2922 (2022)
6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been reported to have some bioactive effects including anticancer and antioxidant effects. However, there are no reports on its effe
Externí odkaz:
https://doaj.org/article/e3640d084b8840a3ba4e5537e84c513d
Autor:
Muhammad Nazmul Hasan, Toshinori Hyodo, Mrityunjoy Biswas, Md Lutfur Rahman, Yuko Mihara, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294146 (2023)
CRISPR/Cas9 is a powerful genome editing system that has remarkably facilitated gene knockout and targeted knock-in. To accelerate the practical use of CRISPR/Cas9, however, it remains crucial to improve the efficiency, precision, and specificity of
Externí odkaz:
https://doaj.org/article/ee84611c0553434eac87c559464f4cbf
Autor:
Md. Lutfur Rahman, Toshinori Hyodo, Sivasundaram Karnan, Akinobu Ota, Muhammad Nazmul Hasan, Yuko Mihara, Md Wahiduzzaman, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Tandem paired nicking (TPN) is a method of genome editing that enables precise and relatively efficient targeted knock-in without appreciable restraint by p53-mediated DNA damage response. TPN is initiated by introducing two site-specific ni
Externí odkaz:
https://doaj.org/article/b018edf2c7bd485b94b5fd71b1d3fa74
Autor:
Shinobu Tsuzuki, Takahiko Yasuda, Hiroaki Goto, Naoko Maeda, Koshi Akahane, Takeshi Inukai, Hideyuki Yamamoto, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Yoshitaka Hosokawa, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is an intractable disease and most cases harbor genetic alterations that activate JAK or ABL signaling. The commonest subtype of Ph-like ALL exhibits a CRLF2 gene rearrangement t
Externí odkaz:
https://doaj.org/article/514652542c624b93836c399d9da87c53
Autor:
Ichiro Hanamura, Susumu Suzuki, Akinobu Ota, Satsuki Murakami, Akira Satou, Taishi Takahara, Sivasundaram Karnan, Vu Quang Lam, Ayano Nakamura, Souichi Takasugi, Kazuhiro Yoshikawa, Shogo Banno, Masayuki Ejiri, Toyonori Tsuzuki, Yoshitaka Hosokawa, Ryuzo Ueda, Akiyoshi Takami
Publikováno v:
Hemato, Vol 2, Iss 2, Pp 368-382 (2021)
The clinical and biological significance of programmed death-1 (PD-1) expression by B-lymphoma cells is largely unknown. Here, using multicolor immunofluorescent staining (MC-IF), we investigated PD-1 and PD-L1 expression in PAX5+ (B-lymphoma), CD68+
Externí odkaz:
https://doaj.org/article/aa32f8c19b92443e840c847084530e68
Autor:
Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Souichi Takasugi, Ayano Nakamura, Miyuki Takahashi, Kaori Uchino, Satsuki Murakami, Md Wahiduzzaman, Lam Quang Vu, Md Lutfur Rahman, Muhammad Nazmul Hasan, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Kazuhiro Yoshikawa, Susumu Suzuki, Ryuzo Ueda, Masayuki Ejiri, Yoshitaka Hosokawa, Akiyoshi Takami
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML). Although FLT3 inhibitors have shown clinical benefit in patients with A
Externí odkaz:
https://doaj.org/article/eae8b2e7377a4befa2da2790f20890c7
Autor:
Akira Koshino, Aya Nagano, Akinobu Ota, Toshinori Hyodo, Akane Ueki, Masayuki Komura, Akane Sugimura-Nagata, Masahide Ebi, Naotaka Ogasawara, Kenji Kasai, Yoshitaka Hosokawa, Kunio Kasugai, Satoru Takahashi, Shingo Inaguma
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies with high morbidity and mortality rates. Several biological markers for the prognostication of patient outcome of CRCs are available. Recently, our group identified two
Externí odkaz:
https://doaj.org/article/3708a3c77f164f9c8d1672e0760a9bb0