Zobrazeno 1 - 10 of 206 pro vyhledávání: '"Yoshitaka Hamashima"'
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Akademický článek
Enantioselective 5-exo-Fluorocyclization of Ene-Oximes
Autor: Taiki Rouno, Tomoki Niwa, Kousuke Nishibashi, Nobuharu Yamamoto, Hiromichi Egami, Yoshitaka Hamashima
Publikováno v: Molecules, Vol 24, Iss 19, p 3464 (2019)
The enantioselective 5-exo-fluorocyclization of ene-oxime compounds was demonstrated under phase-transfer catalysis. Although deprotonative fluorinations competed, the chemical yields and the ee values of the desired isoxazoline products were general
Externí odkaz: https://doaj.org/article/a6f5804be0a5404dadc3c8022a79da6e
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4
Charged Chiral Derivatization for Enantioselective Imaging of D-, L-2-Hydroxyglutaric Acid Using Ion Mobility Spectrometry/Mass Spectrometry
Autor: Eiji Sugiyama, Yuki Nishiya, Kenji Yamashita, Ryo Hirokawa, Yoshiteru Iinuma, Takashi Nirasawa, Hajime Mizuno, Yoshitaka Hamashima, Kenichiro Todoroki
A newly synthesized charged chiral tag enabled enantioselective imaging of D-, L-2-hydroxyglutaric acid, which are independently associated with the regulation of DNA methylation. The tag-conjugated diastereomers were ionized efficiently through MALD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbed9595a6696872184d8ef942fe076
https://doi.org/10.26434/chemrxiv-2023-zt1r3-v2
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6
Mechanistic Details of Asymmetric Bromocyclization with BINAP Monoxide: Identification of Chiral Proton-Bridged Bisphosphine Oxide Complex and Its Application to Parallel Kinetic Resolution
Autor: Kenji Yamashita, Ryo Hirokawa, Mamoru Ichikawa, Tatsunari Hisanaga, Yoshihiro Nagao, Ryo Takita, Kohei Watanabe, Yuji Kawato, Yoshitaka Hamashima
Publikováno v: Journal of the American Chemical Society. 144:3913-3924
The mechanism of our previously reported catalytic asymmetric bromocyclization reactions using 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) monoxide was examined in detail by the means of control experiments, NMR studies, X-ray structure analy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51e8a54370bc48418cf52976d0f435e
https://doi.org/10.1021/jacs.1c11816
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9
Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine
Autor: Hiromichi Egami, Naoto Oku, Anna Okishima, Yoshitaka Hamashima, Go Yasuno, Hiroyuki Koide, Yu Hoshino, Tomohiro Asai, Naoki Hayashi
Publikováno v: Biochemical and Biophysical Research Communications. 561:1-6
Synthetic polymers prepared using several functional monomers have attracted attention as cost-effective protein affinity reagents and alternative to antibodies. We previously reported the synthesis of poly NIPAm-based nanoparticles (NPs) using sever
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cecc24f97bcc7b5fdc64817a9e0fb7e
https://doi.org/10.1016/j.bbrc.2021.05.005
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10
Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles
Autor: Yoshitaka Hamashima, Hiroyuki Koide, Hikaru Suzuki, Hiroki Ochiai, Naoto Oku, Tomohiro Asai, Hiromichi Egami
Publikováno v: Biochemical and Biophysical Research Communications. 555:32-39
Protein–protein (e.g., antibody–antigen) interactions comprise multiple weak interactions. We have previously reported that lipid nanoparticles (LNPs) bind to and neutralize target toxic peptides after multifunctionalization of the LNP surface (M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae56969d12b375efb30a9c1881ce1ab
https://doi.org/10.1016/j.bbrc.2021.03.073
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