Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Yoshitaka, Sekido"'
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13586-13598 (2023)
Abstract Background Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characte
Externí odkaz:
https://doaj.org/article/2e0769a87f1741069e13dff8aee89577
Autor:
Koya Suzuki, Masaki Tange, Ryota Yamagishi, Hiroyuki Hanada, Satomi Mukai, Tatsuhiro Sato, Takeshi Tanaka, Tomohiro Akashi, Kenji Kadomatsu, Tohru Maeda, Takashi Miida, Ichiro Takeuchi, Hiroshi Murakami, Yoshitaka Sekido, Yuko Murakami-Tonami
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Many genes responsible for Malignant mesothelioma (MM) have been identified as tumor suppressor genes and it is difficult to target these genes directly at a molecular level. We searched for the gene which showed synthetic lethal phenotype w
Externí odkaz:
https://doaj.org/article/e2ecf7b821284fb48949d85b470deb09
Autor:
Yoshitaka Sekido, Tatsuhiro Sato
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The NF2 tumor suppressor gene is a frequent somatically mutated gene in mesothelioma, with 30%–40% mesotheliomas showing NF2 inactivation. NF2 encodes merlin, a member of the ezrin, radixin, and moesin (ERM) family of proteins that regulate cytoske
Externí odkaz:
https://doaj.org/article/e0deff536cd246848539ab1d115bfa3d
Autor:
Tatsuhiro Sato, Hayao Nakanishi, Ken Akao, Maho Okuda, Satomi Mukai, Tohru Kiyono, Yoshitaka Sekido
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Malignant mesothelioma (MM) is a very aggressive tumor that develops from mesothelial cells, mainly due to asbestos exposure. MM is categorized into three major histological subtypes: epithelioid, sarcomatoid, and biphasic, with t
Externí odkaz:
https://doaj.org/article/81af084e9af34b928ccce8f17553c5ac
Autor:
Man Hagiyama, Takahiro Mimae, Akihiro Wada, Fuka Takeuchi, Azusa Yoneshige, Takao Inoue, Naoyuki Kotoku, Hironobu Hamada, Yoshitaka Sekido, Morihito Okada, Akihiko Ito
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Malignant pleural mesothelioma (MPM) is a highly aggressive malignant tumor, and the effective therapeutic drugs are limited. Thus, the establishment of novel therapeutic method is desired. Considerable proportion of MPMs are shown to express cell ad
Externí odkaz:
https://doaj.org/article/257be0bb6f184393914785936f0d9ed4
Autor:
Li Jiang, Hao Zheng, Qinying Lyu, Shotaro Hayashi, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, Shinya Toyokuni
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101989- (2021)
Non-thermal plasma (NTP), an engineered technology to generate reactive species, induces ferroptosis and/or apoptosis specifically in various-type cancer cells. NTP-activated Ringer's lactate (PAL) is another modality for cancer therapy at preclinica
Externí odkaz:
https://doaj.org/article/b71fff90558a4ababf8650873d693b1d
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Hypoxia and acidity provide microenvironment for selection under evolutionary pressure and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of metalloenzymes present in all life kingdoms, equilibrating the reactions among CO
Externí odkaz:
https://doaj.org/article/e53bd396485f4fd8ac8f8bce553bfa7b
Publikováno v:
Cancer Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d398729eda2e0281b5dcbf42448febe
https://doi.org/10.1002/cam4.6056
https://doi.org/10.1002/cam4.6056
Autor:
Yoshitaka Sekido, Seisuke Hattori, Yoshio Shibagaki, Wataru Shimono, Okio Hino, Toshiyuki Kobayashi, Ken Akao, Emi Mishiro-Sato, Haruna Ikeda, Satomi Mukai, Tatsuhiro Sato
Figure S1. RHEB mRNA expression in different types of cancer. Figure S2. In vivo growth of MeT-5A mesothelial cells expressing exogenous RHEBL1. Figure S3. RHEBL1 binds to SmgGDS. Figure S4. SmgGDS knockdown suppresses the proliferation of mesothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fa916ddf9552c092867f8fc1ebe0be
https://doi.org/10.1158/1541-7786.22526400
https://doi.org/10.1158/1541-7786.22526400
Autor:
Yoshitaka Sekido, Seisuke Hattori, Yoshio Shibagaki, Wataru Shimono, Okio Hino, Toshiyuki Kobayashi, Ken Akao, Emi Mishiro-Sato, Haruna Ikeda, Satomi Mukai, Tatsuhiro Sato
Malignant mesothelioma (MM) is an aggressive tumor that typically develops after a long latency following asbestos exposure. Although mechanistic target of rapamycin complex 1 (mTORC1) activation enhances MM cell growth, the mTORC1 inhibitor everolim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13133738cb4618d735995a4b03afe679
https://doi.org/10.1158/1541-7786.c.6545079.v1
https://doi.org/10.1158/1541-7786.c.6545079.v1