Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yoshiro Toma"'
Autor:
Hiroshi Saito, Tomoko Yuasa, Ryuzo Tahara, Ryu Matsuoka, Taro Morimoto, Takashi Okai, Yoshiaki Furusawa, Yoshiro Toma, Atsushi Yanaihara
Publikováno v:
The Showa University Journal of Medical Sciences. 14:191-197
Autor:
Yuko Tsunoda, Hiroshi Saito, Takumi Yanaihara, Kazutoshi Okubo, N. Tsuchiya, Mitsuo Kusano, Yoshinori Shimizu, Yoshiro Toma, Kazuhisa Shimodaira, Kentaroh Kamiya
Publikováno v:
International Journal of Clinical Oncology. 5:183-187
Background. In recent years, aromatase inhibitors have been used to treat hormone-dependent breast cancer in postmenopausal women. Although gonadotropin-releasing hormone (GnRH) agonists inhibit the growth of breast cancers by estrogen deprivation, i
Publikováno v:
MHR: Basic science of reproductive medicine. 6:469-473
The aim of this study was to evaluate the effect of lactoferrin (LF) on the proliferation of human endometrial stroma cells. In addition, we compared the effect of LF, oestradiol and epidermal growth factor (EGF) on the proliferation of human endomet
Autor:
Hiroshi Saito, Yukiko Shimizu, Yoshiro Toma, Katufumi Otsuki, Yuichi Mitsuhashi, Takumi Yanaihara, Aki Yoda
Publikováno v:
Placenta. 20:175-179
Lactoferrin (LF) has been found in most biological fluids including amniotic fluid and cervical mucus in pregnant women and is released from neutrophils in response to inflammation. It is an important component of the host defence against microbial i
Autor:
Kazutoshi Okubo, Takumi Yanaihara, Hiroshi Saito, Yoshiro Toma, Yukiko Shimizu, Masatoshi Jimbo
Publikováno v:
Journal of Obstetrics and Gynaecology Research. 24:291-297
Objective: Aromatization in the the fetal brain is thought to be involved both in sex differentiation during early development and in adult sexual behavior. Although recently the relationship between aromatase and catecholamine has been disscussed, t
Autor:
Yoshiro Toma, Takumi Yanaihara, Rang Zhang, Kentaroh Kamiya, Yuko Tsunoda, Miki Shibusawa, Mitsuo Kusano, Yukiko Shimizu
Publikováno v:
The Showa University Journal of Medical Sciences. 10:33-39
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 61:117-126
The diverse function of human placental aromatase including estradiol 6alpha-hydroxylase and cocaine N-demethylase activity are described, and the mechanism for the simultaneous metabolism of estradiol to 2-hydroxy- and 6alpha-hydroxyestradiol at the
Publikováno v:
Endocrinology. 137:3791-3796
In studying the diverse functions of aromatase we found that purified and reconstituted aromatase also catalyzes O-deethylation of 7-ethoxycoumarin. Aromatase cytochrome P450 was purified from human term placentas by monoclonal antiaromatase P450 ant
Autor:
Yoshiro, Toma, Takumi, Yanaihara
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine. 63
Autor:
Fangming Zhang, Mark A. Sherman, Yoshio Osawa, Ikuko Kijima, Michael Cho, Dujin Zhou, Yate-Ching Yuan, Elizabeth T. Eng, Yoshiro Toma, Shiuan Chen
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 86(3-5)
The utilization of computer modeling, site-directed mutagenesis, inhibition kinetic analysis and reaction metabolite analysis allows us to better understand the structure-function relationship between aromatase and its inhibitors. Our results have he