Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Yoshiro Sohma"'
Autor:
Isik Turker, Chih-Chieh Yu, Po-Cheng Chang, Zhenhui Chen, Yoshiro Sohma, Shien-Fong Lin, Peng-Sheng Chen, Tomohiko Ai
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70450 (2013)
Apamin sensitive potassium current (I KAS), carried by the type 2 small conductance Ca(2+)-activated potassium (SK2) channels, plays an important role in post-shock action potential duration (APD) shortening and recurrent spontaneous ventricular fibr
Externí odkaz:
https://doaj.org/article/29c32367984b478c96ca52a2dde98311
Autor:
Yuka Kozawa, Akiko Yamamoto, Miyuki Nakakuki, Kotoyo Fujiki, Shiho Kondo, Takuto Okada, Tomoya Fukuyasu, Makoto Yamaguchi, Itsuka Taniguchi, Nao Nomura, Libin Liu, Mayuko Higuchi, Erina Niwa, Yoshiro Sohma, Satoru Naruse, Yoshifumi Takeyama, Hiroshi Ishiguro
Publikováno v:
Journal of Human Genetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca20c567b5ee059c32a7c2f6a85e2e6
https://doi.org/10.1038/s10038-023-01160-2
https://doi.org/10.1038/s10038-023-01160-2
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 96:1-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1495301e84d530554b4297c4b90905
https://doi.org/10.1254/jpssuppl.96.0_1-b-p-011
https://doi.org/10.1254/jpssuppl.96.0_1-b-p-011
Autor:
Takaharu Kondo, Shigeru B. H. Ko, Yoshiro Sohma, Hiroshi Ishiguro, Kieran Smallbone, Martin C. Steward, Makoto Yamaguchi, Akiko Yamamoto
Publikováno v:
The Journal of Physiology. 595:1947-1972
Key points The ductal system of the pancreas secretes large volumes of alkaline fluid containing HCO3- concentrations as high as 140 mm during hormonal stimulation. A computational model has been constructed to explore the underlying ion transport me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb5b20fc7ba4bdb0fd07f7df1c11d6c2
https://doi.org/10.1113/jp273306
https://doi.org/10.1113/jp273306
Publikováno v:
The Journal of General Physiology
Identification of the binding sites for small molecules that alleviate gating defects in CFTR would assist rational drug design for the treatment of cystic fibrosis. Yeh et al. identify two potential binding sites for prototypical CFTR potentiators a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b11fd2ea75df9bc4cdd1e7db95c2bec
https://pubmed.ncbi.nlm.nih.gov/31164398
https://pubmed.ncbi.nlm.nih.gov/31164398
Publikováno v:
The Journal of Physiology. 594:3227-3244
Key points Two functional abnormalities of cystic fibrosis transmembrane conductance regulator (CFTR), a 25% reduction of the single-channel conductance (g) and a ∼13-fold lower open probability (Po ), were found with the R117H mutation that is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c1c5db6887ac19c5da8ccef4dcb6f6
https://doi.org/10.1113/jp271723
https://doi.org/10.1113/jp271723
Autor:
Ying-Chun Yu, Kanako Wakabayashi-Nakao, Hiroshi Ishiguro, Yoshiro Sohma, Miyuki Nakakuki, Tzyh Chang Hwang
Publikováno v:
The journal of physiological sciences : JPS. 69(1)
A massive deletion over three exons 16-17b in the CFTR gene was identified in Japanese CF patients with the highest frequency (about 70% of Japanese CF patients definitely diagnosed). This pathogenic mutation results in a deletion of 153 amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaa81268a972774fa16c54bedbcb0a9
https://pubmed.ncbi.nlm.nih.gov/29951967
https://pubmed.ncbi.nlm.nih.gov/29951967
Publikováno v:
Biophysics and Physicobiology
Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that belongs to the ATP binding cassette protein superfamily. Deletion of phenylalanine at position 508 (ΔF508) is the most common CF-associated mutation and is present i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654b71c3ffe485245df19ec2606b29c3
https://pubmed.ncbi.nlm.nih.gov/29607278
https://pubmed.ncbi.nlm.nih.gov/29607278
Publikováno v:
Current opinion in pharmacology. 34
One major breakthrough in cystic fibrosis research in the past decade is the development of drugs that target the root cause of the disease — dysfunctional CFTR protein. One of the compounds, Ivacaftor or Kalydeco, which has been approved for clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8384ee2905f5cb8f7f179b9a1ec481
https://pubmed.ncbi.nlm.nih.gov/29073476
https://pubmed.ncbi.nlm.nih.gov/29073476
Autor:
Shuntaro Chiba, Tadaomi Furuta, Minoru Sakurai, Norio Yoshida, Tomoka Furukawa-Hagiya, Tomohiko Hayashi, Yoshiro Sohma
Publikováno v:
Chem. Phys. Lett.. :165-170
ATP binding cassette proteins shuttle a variety of molecules across cell membranes. The substrate transportation process is initiated by the ATP-driven dimerization of nucleotide binding domains (NBDs). Here, the integral-equation theory of liquids w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766e4958c32ed1dc8dbc653a1a5a187f
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100677376
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100677376