Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Yoshiro Kohno"'
Publikováno v:
Current Drug Metabolism. 7:135-146
The purpose of this study was to propose a new method to predict in vivo drug-drug interactions (DDIs) for a high clearance drug from in vitro data. As the high clearance drug, NE-100 (N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4690fc84eb235cdf1ae409ba21f3438
https://doi.org/10.2174/138920006775541570
https://doi.org/10.2174/138920006775541570
Autor:
Yoshiro Kohno, Naoko Hagima, Kiyoshi Nagata, Takahito Yamamoto, Yasushi Yamazoe, Masato Nakamura
Publikováno v:
Xenobiotica. 34:687-703
It has previously been reported that N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) was predominantly metabolized by cytochrome P450 (CYP) 2D6 in human liver microsomes (HLM). In the present study, the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::849c9a84c7f076be82b637e809ffd017
https://doi.org/10.1080/00498250412331281070
https://doi.org/10.1080/00498250412331281070
Autor:
Kiyoshi Nagata, Masato Nakamura, Yasushi Yamazoe, Takahito Yamamoto, Naoko Hagima, Yoshiro Kohno
Publikováno v:
Drug Metabolism and Disposition. 31:60-66
N,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100) has been developed to treat subjects with schizophrenia. This drug is mainly excreted in the form of oxidative metabolites. In the present study, identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db2e9d6e68446abec34186802c78f10
https://doi.org/10.1124/dmd.31.1.60
https://doi.org/10.1124/dmd.31.1.60
Autor:
Naoko Hagima, Yasushi Yamazoe, Kiyoshi Nagata, Yoshiro Kohno, Junichi Yamaguchi, Misako Fukasawa, Takahito Yamamoto, Masato Nakamura
Publikováno v:
Drug Metabolism and Pharmacokinetics. 18:173-185
Summary: In the present study, human cytochrome P450 (CYP) forms involved in producing the primary metabolites of NE-100 were identified. Major metabolites of NE-100 in human liver microsomes (HLM) were N -depropylation of NE-100 (NE-098), p -hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78408bacd5ae17b3882661cb03d70f2
https://doi.org/10.2133/dmpk.18.173
https://doi.org/10.2133/dmpk.18.173
Publikováno v:
Drug Metabolism and Pharmacokinetics. 17:437-448
Summary: Using a microtiter plate (MTP) assay consists of recombinant cytochromes P450 and fluorescent probes, we evaluated inhibitory effects of commercially available model-compounds, 18 typical substrates and 8 selective inhibitors, on nine cytoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adaf0e38c377795915d5c94098d238a
https://doi.org/10.2133/dmpk.17.437
https://doi.org/10.2133/dmpk.17.437
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:16-21
To examine whether the retention of imidazole analogues in the organ rich with elastic connective tissue can be of toxicological significance, the effect of 14C labeled 2-methylimidazole (2MI) as a model compound on the mechanical, biochemical, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23aaadaff5b400747efc13f4f05961e4
https://doi.org/10.2133/dmpk.14.16
https://doi.org/10.2133/dmpk.14.16
Publikováno v:
The Japanese Journal of Pharmacology. 81:107-114
Prostaglandin E1 incorporated in lipid microspheres (lipo PGE1) was administered to the umbilical vein of neonatal rats. Morphological measurement and quantitative autoradioluminography assessed the relationship between the vasodilating effect and ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d84e44539082d0c3a215d717979028
https://doi.org/10.1254/jjp.81.107
https://doi.org/10.1254/jjp.81.107
Autor:
Junichi Yamaguchi, Yoshiro Kohno, Toshio Suwa, Hideo Yoshida, Hiromi Endo, Masahiro Hayashi, Kiyomi Fukushima
Publikováno v:
Biochemical Pharmacology. 53:179-187
The chiral inversion properties of 4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (KE-748), an active metabolite of 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298), were compared with those of ibuprofen in rats. After admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3f5450eb6b86258736962909ec423f
https://doi.org/10.1016/s0006-2952(96)00658-2
https://doi.org/10.1016/s0006-2952(96)00658-2
Autor:
Hideo Yoshida, Yoshiro Kohno, Toshio Suwa, Kazuyuki Tomisawa, Hiromi Endo, Masatoshi Hasegawa, Jyunichi Yamaguchi
Publikováno v:
Biological and Pharmaceutical Bulletin. 19:424-429
To characterize the pharmacokinetic properties of a new antirheumatic drug, KE-298, the metabolic fate of [ 14 C]labeled KE-298 in rats was investigated, focussing especially on the identification of metabolites and its physiological properties. [ 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f2b5df75f740ae720e85b263527c59
https://doi.org/10.1248/bpb.19.424
https://doi.org/10.1248/bpb.19.424
Autor:
Saburo Sugai, Shiro Kondo, Toshio Tanaka, Isao Watanabe, Ryuji Tamaya, Toshio Suwa, Junji Shimazaki, Koichi Mitsugi, Yoshiro Kohno, Toshiya Minagawa, Kenji Manabe, Yoshio Esumi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:344-358
Blood levels, excretion and metabolism of 3H labeled isocarbacyclin methyl ester given in the form of an oil-in-water emulsion (3H-TTC-909) were compared with those after administration of the saline solution form (3H-TEI-9090) in the dog.1. After ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec8c831a93e9177fc4e18c273b2dc4b
https://doi.org/10.2133/dmpk.10.344
https://doi.org/10.2133/dmpk.10.344