Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yoshiro Kitahara"'
Autor:
Yuko Tateishi, Reiko Ichikawa, Katsuya Suzuki, Yoshiro Kitahara, Yuki Someya, Yoshifumi Tamura
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
BackgroundIron deficiency and underweight are common nutritional problems among young Japanese women, many of whom show unhealthy dietary patterns owing to a desire for thinness. We conducted a cross-sectional analysis of the relationship between iro
Externí odkaz:
https://doaj.org/article/b81b1fdf0e1a41cda015230d0148f292
Autor:
Takuya Seki, Kei Yamada, Yuri Ooba, Tomohiro Fujii, Takahiro Narita, Akira Nakayama, Yoshiro Kitahara, Brian A. Mendelsohn, Yutaka Matsuda, Tatsuya Okuzumi
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 8, p 234 (2022)
Background: Trastuzumab-emtansine (T-DM1, commercial name: Kadcyla) is well-known antibody-drug conjugate (ADC) and was first approved for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. This molecular format consis
Externí odkaz:
https://doaj.org/article/c38f812fbc994049940757f4232ddaa8
Autor:
Sayaka Kawaguchi, Yuri Ooba, Akira Nakayama, Yutaka Matsuda, Tatsuya Okuzumi, Fujii Tomohiro, Brian A. Mendelsohn, Kazutoshi Takahashi, Kei Yamada, Takuya Seki, Takahiro Narita, Yoshiro Kitahara
Publikováno v:
Molecular Pharmaceutics. 18:4058-4066
To overcome a lack of selectivity during the chemical modification of native non-engineered antibodies, we have developed a technology platform termed "AJICAP" for the site-specific chemical conjugation of antibodies through the use of a class of IgG
Autor:
Yuichi Nakahara, Uno Tagami, Ippei Inoue, Yuta Endo, Yasuyo Suga, Yoriko Okamatsu, Naofumi Okamoto, Mayumi Chiba, Kazutoshi Takahashi, Kenichiro Ito, Yoshiro Kitahara
Publikováno v:
Nanoscale. 13(3)
Conventionally, a disassembly and reassembly method has been used for encapsulation of drug molecules in ferritin protein nano-cages. However, clinical applications of ferritin have been greatly restricted by its limited drug-loading capacity and pro
Autor:
Yutaka Matsuda, Takuya Seki, Kei Yamada, Yuri Ooba, Kazutoshi Takahashi, Tomohiro Fujii, Sayaka Kawaguchi, Takahiro Narita, Akira Nakayama, Yoshiro Kitahara, Mendelsohn, Brian A., Tatsuya Okuzumi
Publikováno v:
Molecular Pharmaceutics; 11/1/2021, Vol. 18 Issue 11, p4058-4066, 9p
Autor:
Kunio Nakata, Yoshiro Kitahara, Yoriko Okamatsu, Masumi Taki, Hirasawa Shigeo, Satoko Ueno, Akira Nakayama, Fujii Tomohiro, Chiori Ijichi, Fumie Futaki
Publikováno v:
Bioconjugate chemistry. 30(9)
The formation of Fc-fusions, in which biologically active molecules and the Fc fragment of antibodies are linked to each other, is one of the most efficient and successful half-life extension technologies to be developed and applied to peptide and pr
Publikováno v:
Diabetes. 67
Bariatric surgery induces metabolic improvement before weight loss occurs. Plasma levels of bile acids (BA) are increased after bariatric surgery and this change is reported to contribute significantly to metabolic improvement. In this study, we inve
Publikováno v:
Analytical Biochemistry. 472:45-51
Glucagon-like peptide-1 (GLP-1) is an incretin peptide that regulates islet hormone secretion. During recent years, incretin-based therapies have been widely used for patients with type 2 diabetes. GLP-1 peptides undergo N- and C-terminal processing
Autor:
Yoshiro Kitahara, Masatoshi Nomura, Kazuhiro Shima, Hiroshi Omote, Tsuyoshi Inoue, Ken Iwatsuki, Yoshinori Moriyama, Miki Hiasa, Yasuo Endo, Nao Hasuzawa, Reiko Ichikawa, Takaaki Miyaji, Yuri Kato, Atsushi Kadowaki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(31)
Despite the high incidence of neuropathic and inflammatory pain worldwide, effective drugs with few side effects are currently unavailable for the treatment of chronic pain. Recently, researchers have proposed that inhibitors of purinergic chemical t
Autor:
Yuzuru Eto, Shingo Nakajima, Yoshiro Kitahara, Hiroshi Hara, Arimi Mitsunaga, Eri Sato, Tohru Hira, Maya Muramatsu
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 306:G1099-G1107
The calcium-sensing receptor (CaSR) is expressed in various tissues, including the gastrointestinal tract. To investigate the role of gut CaSR on glycemic control, we examined whether single oral administration of CaSR agonist peptides affected the g