Výsledky vyhledávání - "Yoshio Mitamura"

Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia

Autor: Tuneaki Hirakawa, S Iida, Satoshi Wakita, Hiroki Yamaguchi, Koiti Inokuchi, Tomoaki Kitano, Kunihito Arai, Saiko Kurosawa, E Manabe, Yoshio Mitamura, Tsuyoshi Ryotokuji, Fumiko Kosaka, Ikuko Omori, Y Sato, T Todoroki, Kazuki Terada, T Ibaraki, Takahiro Ueda, Kazuo Dan

Publikováno v: Leukemia. 27:1044-1052

Gene mutations were found in acute myeloid leukemia (AML) and their importance has been noted. To clarify the importance and stability of mutations, we examined gene mutations in paired samples at diagnosis and relapse of 34 adult AML patients. Five

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57dc4b85684e8d69a58b2ce9292a1d9c
https://doi.org/10.1038/leu.2012.317

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Multistep pathogenesis of leukemia via the MLL-AF4 chimeric gene/Flt3 gene tyrosine kinase domain (TKD) mutation-related enhancement of S100A6 expression

Autor: Hideki Hanawa, Hiroki Yamaguchi, K Dan, Yoshio Mitamura, Koiti Inokuchi, Takashi Shimada, Kazuhiro Sawaguchi, Naoya Uchida, Mitsuharu Inamai

Publikováno v: Experimental Hematology. 37:701-714

Objective Concerning MLL-AF4 leukemogenesis, previous mouse models suggest that the tumorigenesis capacity of MLL-AF4 alone is insufficient for causing leukemia. Based on the finding that an Fms-like tyrosine kinase 3 (Flt3) gene mutation in the tyro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48627ee076a842f215fa8d4c587093b7
https://doi.org/10.1016/j.exphem.2009.02.007

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Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes

Autor: Koiti Inokuchi, Kazuo Dan, Hiroki Yamaguchi, Seiji Gomi, Hinh Ly, Kazuhiro Sawaguchi, Kathryn A. Carroll, Junko Takeuchi, Ayako Watanabe, Yoshio Mitamura, Fumiko Kosaka

Publikováno v: Blood Cells, Molecules, and Diseases. 40:185-191

As the incidence of bone-marrow failure syndromes (BMFS) is 2–3× higher in East Asia than in the West, we examined peripheral blood or marrow cells of 100 Japanese patients for possible pathogenic mutations in the two main components of the telome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71deaa97e78835ddb00a9d984026476e
https://doi.org/10.1016/j.bcmd.2007.08.002

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Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia

Autor: Satoshi Wakita, Hiroki Yamaguchi, Kazuo Dan, Yoshio Mitamura, Koiti Inokuchi, Fumiko Kosaka, Koichi Miyake

Publikováno v: Leukemia. 25(9)

Recently, c-kit mutations have been reported as a novel adverse prognostic factor of acute myeloid leukemia with t(8;21)(q22;q22) translocation (t(8;21) AML). However, much remains unclear about its clinical significance. In this study, we developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94cd58d5dafca4676fa0a85287704f8
https://pubmed.ncbi.nlm.nih.gov/21606963

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The Prognostic Impact Of Complex Gene Mutation In The Intermediate Risk Karyotype Acute Myeloid Leukemia

Autor: Satoshi Wakita, Hiroki Yamaguchi, Tuneaki Hirakawa, Ikuko Omori, Tomoaki Kitano, Yoshio Mitamura, Kunihito Arai, Kazuo Dan, Takeshi Ryotokuji, Koiti Inokuchi, Fumiko Kosaka

Publikováno v: Blood. 122:1418-1418

Background Many gene mutations were detected and overlapped in de novo acute myeloid leukemia (AML), but the prognosis of complex gene mutation remains to be unclear. In this study, we analyzed the prognostic impact of complex gene mutation in de nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d78f47fc97b5a3a44bf9e3ce4661ddf
https://doi.org/10.1182/blood.v122.21.1418.1418

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