Zobrazeno 1 - 10
of 674
pro vyhledávání: '"Yoshio Hayashi"'
Autor:
Hiroaki Miyauchi, Koshu Okubo, Kiriko Iida, Hiroshi Kawakami, Kentaro Takayama, Yoshio Hayashi, Junji Haruta, Junichi Sasaki, Kaori Hayashi, Junichi Hirahashi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Crush syndrome, which frequently occurs in earthquake disasters, often leads to rhabdomyolysis induced acute kidney injury (RIAKI). Recent findings indicate that systemic inflammatory response syndrome (SIRS) exacerbates muscle collapse, contributing
Externí odkaz:
https://doaj.org/article/2a61a59683c848548f7783e09a80f5f8
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 397 (2023)
Sarcopenia is a major public health issue that affects older adults. Myostatin inhibitory-D-peptide-35 (MID-35) can increase skeletal muscle and is a candidate therapeutic agent, but a non-invasive and accessible technology for the intramuscular deli
Externí odkaz:
https://doaj.org/article/8a506897109947f2b6f7104b334ec1af
Autor:
Kyohei Muguruma, Konomi Fujita, Akane Fukuda, Satoshi Kishimoto, Soichiro Sakamoto, Risako Arima, Mayu Ito, Mayu Kawasaki, Shogo Nakano, Sohei Ito, Kanade Shimizu, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi
Publikováno v:
ACS Omega, Vol 4, Iss 11, Pp 14390-14397 (2019)
Externí odkaz:
https://doaj.org/article/86504a125b354796878b3cd771ed76b5
Autor:
Naozumi Ishimaru, Yoshio Hayashi
Publikováno v:
Japanese Dental Science Review, Vol 45, Iss 1, Pp 41-45 (2009)
Autoimmune diseases reveal complex and multigenic phenotypes affected by a variety of genetic and environmental or stochastic factors. A lot of models for autoimmune diseases including Sjögren's syndrome (SS) have been demonstrated using gene-manipu
Externí odkaz:
https://doaj.org/article/aaf8520ef4e14e1b8f116836813baafa
Autor:
Yutaka Ohsawa, Kentaro Takayama, Shin-ichiro Nishimatsu, Tadashi Okada, Masahiro Fujino, Yuta Fukai, Tatsufumi Murakami, Hiroki Hagiwara, Fumiko Itoh, Kunihiro Tsuchida, Yoshio Hayashi, Yoshihide Sunada
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133713 (2015)
Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulati
Externí odkaz:
https://doaj.org/article/d84e91bda6ef4f7da64228030dc9be37
Autor:
Kohei Okuyama, Atsushi Kaida, Yoshiki Hayashi, Yoshio Hayashi, Kiyoshi Harada, Masahiko Miura
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145995 (2015)
KPU-300 is a novel colchicine-type anti-microtubule agent derived from plinabulin (NPI-2358). We characterized the effects of KPU-300 on cell cycle kinetics and radiosensitization using HeLa cells expressing the fluorescent ubiquitination-based cell
Externí odkaz:
https://doaj.org/article/65326c6e7efc492faec199c259ad7b59
Autor:
Rieko Arakaki, Hiroshi Eguchi, Akiko Yamada, Yasusei Kudo, Akihiko Iwasa, Tserennadmid Enkhmaa, Fumika Hotta, Sayaka Mitamura-Aizawa, Yoshinori Mitamura, Yoshio Hayashi, Naozumi Ishimaru
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98390 (2014)
Topical therapy is effective for dry eye, and its prolonged effects should help in maintaining the quality of life of patients with dry eye. We previously reported that the oral administration of rebamipide (Reb), a mucosal protective agent, had a po
Externí odkaz:
https://doaj.org/article/11c0074920ae4bc79a25ce603d2713b3
Autor:
Takashi Izawa, Tomoyuki Kondo, Mie Kurosawa, Ritsuko Oura, Kazuma Matsumoto, Eiji Tanaka, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Yoshio Hayashi, Naozumi Ishimaru
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e48798 (2012)
BackgroundAlthough autoimmunity in MRL/lpr mice occurs due to a defect in Fas-mediated cell death of T cells, the role of Fas-independent apoptosis in pathogenesis has rarely been investigated. We have recently reported that receptor activator of nuc
Externí odkaz:
https://doaj.org/article/c8c0b3f4099249fa933d03ecde6e3f50
Autor:
Megumi Watanabe, Naozumi Ishimaru, Meinar Nur Ashrin, Rieko Arakaki, Akiko Yamada, Tetsuo Ichikawa, Yoshio Hayashi
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19017 (2011)
Although the activation of dermal dendritic cells (DCs) or Langerhans cells (LCs) via p38 mitogen-activated protein kinase (MAPK) plays a crucial role in the pathogenesis of metal allergy, the in vivo molecular mechanisms have not been identified and
Externí odkaz:
https://doaj.org/article/ac1731728816457a8d068e178a53c923
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12894 (2010)
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet β cells. To determine whether specific lysosomal proteases might influenc
Externí odkaz:
https://doaj.org/article/859e8cc3a07e4edbbec0c816189e8654