Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Yoshio ESUMI"'
Autor:
Kazuoki Tsuruda, Hironori Arizono, Yasuhiro Takahashi, Yoshio Esumi, Noriyuki Saito, Shin-ichi Nishimura, Shigeyuki Ishii, Yoshitaka Jin, Hiroyuki Nemoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:569-583
The Pharmacokinetics of 3H-BN·HCl in male rats was studied after a single percutaneous (3HTSN-09 : 3H-BN·HCl containing tape) or subcutaneous administration of 3H-BN·HCl. 1. The radioactivity level in blood reached the Cmax at 21.6 hr after a sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06b762a6179fc674814a204841d7229e
https://doi.org/10.2133/dmpk.16.569
https://doi.org/10.2133/dmpk.16.569
Autor:
Shuichiro Tsutsumi, Katsuhiro Inada, Atsuhiro Inaba, Megumi Fushimi, Yoshio Esumi, Mitsuyoshi Isaka, Yoshio Karasawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:32-41
The absorption, distribution and metabolism of bromfenac sodium were investigated after single or repeated application of 14C-bromfenac sodium ophthalmic solution to both eyes of male albino rabbits at a dose of 0.1 mg/animal (0.05 mg/50 μl/eye). 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d935f5112b4e380acf0868c0ae77304a
https://doi.org/10.2133/dmpk.14.32
https://doi.org/10.2133/dmpk.14.32
Autor:
Yoshinori Teramura, Akio Kawamura, Shin-ichi Ninomiya, Yoshio Esumi, Kazuhide Iwasaki, Takehisa Hata
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:1-10
The absorption, distribution, and excretion of radioactivity were studied in the male rat after a single dermal application of 14C-labeled FK506 ointment at an FK506 dose level of 1.6 mg/kg. The application period of the ointment was 24 hours. 1. Uri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798a5fc7454d4ff3f5d9bb1e6ba7f99a
https://doi.org/10.2133/dmpk.14.1
https://doi.org/10.2133/dmpk.14.1
Autor:
Toshifumi Shiraga, Shin-ichi Ninomiya, Kouji Takeshita, Yoshio Esumi, Yoshinori Teramura, Akio Kawamura, Akira Kagayama, Masato Terakawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 14:385-391
The penetration and absorption of tacrolimus (FK506) in the skin of rat after a single topical application of 14C-labeled FK506 (14C-FK506) ointment under occlusive dressing was studied by semimicroautoradiography of the skin and by counting radioact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5601fa7d5cf3d88a1e8d582f9697403
https://doi.org/10.2133/dmpk.14.385
https://doi.org/10.2133/dmpk.14.385
Autor:
Norihiro Takenaga, Yoshio Esumi, Hiroyuki Ishizaki, T. Kamei, Shin-ichi Ninomiya, Mikio Ishii
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:337-345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a35c76a2d6e49fa334fe27cbc3e0f868
https://doi.org/10.2133/dmpk.13.337
https://doi.org/10.2133/dmpk.13.337
Autor:
Ken'ichi Hara, Yoshio Karasawa, Norihiro Takenaga, Yoshio Esumi, Hidemasa Seki, Kazumi Ichige, Tomoko Sakuma, Akihiro Hisaka, T. Kamei
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:252-258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf027cf729a0fd6dd952b97e6bd9935
https://doi.org/10.2133/dmpk.13.252
https://doi.org/10.2133/dmpk.13.252
Autor:
Shunji NAKAI, Kyoko AKAO, Masaki ITO, Yoshiko MIZUNO, Setsuko KOMURO, Hiroshi KANAMARU, Iwao NAKATSUKA, Yoshio ESUMI, Masao ISHIZAKI, Shinobu GUNJI, Atsushi TAKAO, Kazue KIMURA, Tomoko NAKAYAMA, Shinichi NINOMIYA
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:61-77
Pharmacokinetics on plasma and blood cells concentration, tissue distribution and excretion of amrubicin hydrochloride (SM-5887), a novel antitumor agent, were investigated after a single intravenous administration of 14C-labeled SM-5887 at the doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbdbd9ad00e8df4ebccfbd9e0322f337
https://doi.org/10.2133/dmpk.13.61
https://doi.org/10.2133/dmpk.13.61
Autor:
Kouwa Yamashita, Shin-ichi Ninomiya, Matsuo Takaichi, Yoshio Esumi, Tsuyoshi Irie, Shin-ichi Matsumoto, Miwa Ootubo, Atsushi Takao, Toshiko Eki, Hideaki Seki
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:221-228
The blood concentration, distribution and excretion of radioactivity were investigated in male rats after daily intravenous administration of 14C-NKH477 for 21 days. The effects of NKH477 on hepatic drug metabolizing enzyme system were also investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e9ca574c86051baba8f3a4ee3f2aa98
https://doi.org/10.2133/dmpk.13.221
https://doi.org/10.2133/dmpk.13.221
Autor:
Yoshinori Teramura, Kazuhide Iwasaki, Shin-ichi Ninomiya, Hiroji Matsuda, Yoshio Esumi, Takehisa Hata, Akio Kawamura, Toshifumi Shiraga
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:259-265
The absorption, distribution, metabolism and excretion of tacrolimus (FK506) were studied in the rat after intravenous (i.v.) and oral administration of 14C-labeled FK506 (14C-FK506). 1. After i.v. injection at a dose level of 1.0 mg/kg, the pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c3adf49df6d15cf4784daf4bf25551
https://doi.org/10.2133/dmpk.13.259
https://doi.org/10.2133/dmpk.13.259
Autor:
Yasuro Kawaguchi, Katsuyuki Hori, Hirotoshi Masuda, Sekio Nagayama, Yoshio Esumi, Toshiyuki Mashiko
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:355-386
S-1, a new oral anti-cancer drug, is composed of tegafur (FT), gimestat (CDHP) and potassium otastat (Oxo) in a molar ratio of 1 : 0.4 : 1. FT which is masked compound of 5-fluorouracil (5-FU) plays a role as an effector. Both CDHP and Oxo which do n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e2c3045048e8a2d83cdb4492b0af87
https://doi.org/10.2133/dmpk.12.355
https://doi.org/10.2133/dmpk.12.355