Zobrazeno 1 - 10 of 961 pro vyhledávání: '"Yoshio Hayashi"'
1
Akademický článek
Multiple site inflammation and acute kidney injury in crush syndrome
Autor: Hiroaki Miyauchi, Koshu Okubo, Kiriko Iida, Hiroshi Kawakami, Kentaro Takayama, Yoshio Hayashi, Junji Haruta, Junichi Sasaki, Kaori Hayashi, Junichi Hirahashi
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
Crush syndrome, which frequently occurs in earthquake disasters, often leads to rhabdomyolysis induced acute kidney injury (RIAKI). Recent findings indicate that systemic inflammatory response syndrome (SIRS) exacerbates muscle collapse, contributing
Externí odkaz: https://doaj.org/article/2a61a59683c848548f7783e09a80f5f8
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2
Akademický článek
Increasing Skeletal Muscle Mass in Mice by Non-Invasive Intramuscular Delivery of Myostatin Inhibitory Peptide by Iontophoresis
Autor: Kohki Michiue, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi, Kentaro Kogure
Publikováno v: Pharmaceuticals, Vol 16, Iss 3, p 397 (2023)
Sarcopenia is a major public health issue that affects older adults. Myostatin inhibitory-D-peptide-35 (MID-35) can increase skeletal muscle and is a candidate therapeutic agent, but a non-invasive and accessible technology for the intramuscular deli
Externí odkaz: https://doaj.org/article/8a506897109947f2b6f7104b334ec1af
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5
Inactivation of myostatin by photooxygenation using functionalized d-peptides
Autor: Hideyuki Okamoto, Shuko Amber Murano, Kaoru Ikekawa, Masahiro Katsuyama, Sho Konno, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
Publikováno v: RSC Medicinal Chemistry. 14:386-392
Myostatin-binding d-peptides functionalized with photocatalyst efficiently inactivate myostatin by photooxygenation and show no phototoxicity and high resistance to proteolytic enzymes, leading to the treatment of muscular atrophic diseases.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73c442d5b725c15e6bb798137ca3442e
https://doi.org/10.1039/d2md00425a
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8
Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice
Autor: Kentaro Takayama, Keisuke Hitachi, Hideyuki Okamoto, Mariko Saitoh, Miki Odagiri, Rina Ohfusa, Takahiro Shimada, Akihiro Taguchi, Atsuhiko Taniguchi, Kunihiro Tsuchida, Yoshio Hayashi
Publikováno v: ACS Med Chem Lett
[Image: see text] Myostatin is a key negative regulator of skeletal muscle growth, and myostatin inhibitors are attractive tools for the treatment of muscular atrophy. Previously, we reported a series of 14–29-mer peptide myostatin inhibitors, incl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40cd8654e1843fc3cf77724b94de2fd
https://doi.org/10.1021/acsmedchemlett.1c00705
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10
Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application
Autor: Chika Azuma, Shunsuke Sawamura, Kohei Tsuji, Hirokazu Tamamura, Takuya Kobayakawa, Atsuhiko Taniguchi, Yuki Watanabe, Yoshio Hayashi
Publikováno v: The Journal of Organic Chemistry. 86:5091-5101
Improved methods of convergent synthesis for peptidomimetic utilizing a chloroalkene dipeptide isostere (CADI) are reported. In this synthesis, Fmoc- or Boc-protected carboxylic acids can be produced from N- and C-terminal analogues corresponding to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d603353fab9db24fc199a06f2283a4bc
https://doi.org/10.1021/acs.joc.0c03019
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