Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yoshinori Tsukumo"'
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-12 (2020)
Abstract Background Next Generation Sequencer (NGS) is a powerful tool for a high-throughput sequencing of human genome. It is important to ensure reliability and sensitivity of the sequence data for a clinical use of the NGS. Various cancer-related
Externí odkaz:
https://doaj.org/article/d28d1308280f4a3e9180ccb303abb1f7
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229712 (2020)
In non-small cell lung cancer (NSCLC), oncogenic driver mutations including those in KRAS and EGFR are typically mutually exclusive. However, recent reports indicate that multiple driver mutations are found in a certain percentage of cancers, and tha
Externí odkaz:
https://doaj.org/article/015d4ad6e8f943d582aac7183b7f5699
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Technologies that induce targeted protein degradation by small molecules have been developed recently. Chimeric small molecules such as Proteolysis Targeting Chimeras (PROTACs) and Specific and Non-genetic IAP-dependent Protein Erasers (SNIPERs), and
Externí odkaz:
https://doaj.org/article/0202f04ad5cd4731902b7909fa7226bb
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and ant
Externí odkaz:
https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
Autor:
Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Toru Natsume, Akihiro Tomida
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112761 (2014)
Under ER stress, PKR-like ER-resident kinase (PERK) phosphorylates translation initiation factor eIF2α, resulting in repression of global protein synthesis and concomitant upregulation of the translation of specific mRNAs such as activating transcri
Externí odkaz:
https://doaj.org/article/39d30275341b41f8917e887f66f2c707
Autor:
Nobumichi Ohoka, Masanori Suzuki, Takuya Uchida, Genichiro Tsuji, Yoshinori Tsukumo, Masayuki Yoshida, Takao Inoue, Yosuke Demizu, Hitoshi Ohki, Mikihiko Naito
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1885-1891
Internal tandem duplication (ITD) in the gene encoding FMS-like tyrosine kinase 3 (
Autor:
Akihiro Tomida, Toshiki Watanabe, Masaaki Matsuura, Masaru Ushijima, Hiromichi Kondo, Shigeo Sato, Junko Sakurai, Satomi Tsukahara, Sakae Saito, Yoshinori Tsukumo, Junichi Matsuo
Biguanides, including metformin, buformin, and phenformin, are potential antitumorigenic agents and induce cell death during glucose deprivation, a cell condition that occurs in the tumor microenvironment. Here, we show that this selective killing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c8235519deec2572d4771975bfcb32
https://doi.org/10.1158/1535-7163.c.6536142
https://doi.org/10.1158/1535-7163.c.6536142
Autor:
Akihiro Tomida, Toshiki Watanabe, Masaaki Matsuura, Masaru Ushijima, Hiromichi Kondo, Shigeo Sato, Junko Sakurai, Satomi Tsukahara, Sakae Saito, Yoshinori Tsukumo, Junichi Matsuo
PDF file - 292K, hyperactivation of 4E-BP1 in UPR inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b81f438a87e45bc1e70fdd8f5f328d5
https://doi.org/10.1158/1535-7163.22499433.v1
https://doi.org/10.1158/1535-7163.22499433.v1
Autor:
Nobumichi Ohoka, Masanori Suzuki, Takuya Uchida, Yoshinori Tsukumo, Masayuki Yoshida, Takao Inoue, Hitoshi Ohki, Mikihiko Naito
Publikováno v:
Cancer Science. 113:2828-2838
Autor:
Nobumichi, Ohoka, Masanori, Suzuki, Takuya, Uchida, Yoshinori, Tsukumo, Masayuki, Yoshida, Takao, Inoue, Hitoshi, Ohki, Mikihiko, Naito
Publikováno v:
Cancer science. 113(8)
BRAF mutations are frequently observed in melanoma and hairy-cell leukemia. Currently approved rapidly accelerated fibrosarcoma (RAF) kinase inhibitors targeting oncogenic BRAF V600 mutations have shown remarkable efficacy in the clinic, but their th