Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Yoshinori Tsukumo"'
1
Akademický článek
Preparation of the standard cell lines for reference mutations in cancer gene-panels by genome editing in HEK 293 T/17 cells
Autor: Takayoshi Suzuki, Yoshinori Tsukumo, Chie Furihata, Mikihiko Naito, Arihiro Kohara
Publikováno v: Genes and Environment, Vol 42, Iss 1, Pp 1-12 (2020)
Abstract Background Next Generation Sequencer (NGS) is a powerful tool for a high-throughput sequencing of human genome. It is important to ensure reliability and sensitivity of the sequence data for a clinical use of the NGS. Various cancer-related
Externí odkaz: https://doaj.org/article/d28d1308280f4a3e9180ccb303abb1f7
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2
Akademický článek
Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line.
Autor: Yoshinori Tsukumo, Mikihiko Naito, Takayoshi Suzuki
Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0229712 (2020)
In non-small cell lung cancer (NSCLC), oncogenic driver mutations including those in KRAS and EGFR are typically mutually exclusive. However, recent reports indicate that multiple driver mutations are found in a certain percentage of cancers, and tha
Externí odkaz: https://doaj.org/article/015d4ad6e8f943d582aac7183b7f5699
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3
Akademický článek
Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs
Autor: Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Yoshinori Tsukumo
Publikováno v: Frontiers in Chemistry, Vol 7 (2019)
Technologies that induce targeted protein degradation by small molecules have been developed recently. Chimeric small molecules such as Proteolysis Targeting Chimeras (PROTACs) and Specific and Non-genetic IAP-dependent Protein Erasers (SNIPERs), and
Externí odkaz: https://doaj.org/article/0202f04ad5cd4731902b7909fa7226bb
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6
Data from Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation
Autor: Akihiro Tomida, Toshiki Watanabe, Masaaki Matsuura, Masaru Ushijima, Hiromichi Kondo, Shigeo Sato, Junko Sakurai, Satomi Tsukahara, Sakae Saito, Yoshinori Tsukumo, Junichi Matsuo
Biguanides, including metformin, buformin, and phenformin, are potential antitumorigenic agents and induce cell death during glucose deprivation, a cell condition that occurs in the tumor microenvironment. Here, we show that this selective killing of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c8235519deec2572d4771975bfcb32
https://doi.org/10.1158/1535-7163.c.6536142
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8
Akademický článek
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
Autor: Yoshinori Tsukumo, Tommy Alain, Bruno D. Fonseca, Robert Nadon, Nahum Sonenberg
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and ant
Externí odkaz: https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
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9
Development of a potent small-molecule degrader against oncogenic BRAF
Autor: Nobumichi, Ohoka, Masanori, Suzuki, Takuya, Uchida, Yoshinori, Tsukumo, Masayuki, Yoshida, Takao, Inoue, Hitoshi, Ohki, Mikihiko, Naito
Publikováno v: Cancer science. 113(8)
BRAF mutations are frequently observed in melanoma and hairy-cell leukemia. Currently approved rapidly accelerated fibrosarcoma (RAF) kinase inhibitors targeting oncogenic BRAF V600 mutations have shown remarkable efficacy in the clinic, but their th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92b2d1dabfff7784cf28a804eefbfc36
https://pubmed.ncbi.nlm.nih.gov/35579105
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10
Preparation of the standard cell lines for reference mutations in cancer gene-panels by genome editing in HEK 293 T/17 cells
Autor: Chie Furihata, Mikihiko Naito, Takayoshi Suzuki, Yoshinori Tsukumo, Arihiro Kohara
Publikováno v: Genes and Environment, Vol 42, Iss 1, Pp 1-12 (2020)
Genes and Environment
Background Next Generation Sequencer (NGS) is a powerful tool for a high-throughput sequencing of human genome. It is important to ensure reliability and sensitivity of the sequence data for a clinical use of the NGS. Various cancer-related gene pane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf407b907bd54a8c77bd68c43bb9179
https://doaj.org/article/d28d1308280f4a3e9180ccb303abb1f7
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