Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yoshinori Toshima"'
Autor:
T. Asano, Shin ichi Satoh, Hiroaki Shimokawa, Yoshinori Toshima, Atsushi Watanabe, Ichiro Ikegaki
Publikováno v:
Life Sciences. 72:103-112
The aim of this study was to develop a new model of vasopressin-induced chronic myocardial damage based on sustained ST-segment depression in electrocardiogram (ECG) with progression of myocardial fibrosis in rats. Furthermore, using this model, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d609b9dc9f1e76f638add09a81cda4c2
https://doi.org/10.1016/s0024-3205(02)02178-1
https://doi.org/10.1016/s0024-3205(02)02178-1
Publikováno v:
British Journal of Pharmacology. 134:1724-1730
1. The effects of Rho-kinase inhibitor, fasudil, and of a more specific Rho-kinase inhibitor, hydroxyfasudil, on pacing-induced myocardial ischaemia were determined in anaesthetized open-chest dogs. 2. The dogs were subjected to left anterior descend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049f23ee0ef76175afb2cbd6df68631a
https://doi.org/10.1038/sj.bjp.0704410
https://doi.org/10.1038/sj.bjp.0704410
Publikováno v:
Stroke. 31:2245-2250
Background and Purpose —The aim of this study was to develop a new model of stroke based on endothelial damage and thrombotic occlusion in a perforating artery, leading to small cerebral infarcts and neurological deficits in rats. Moreover, the neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3549a4d050b30ba8d9d40b254def22ce
https://doi.org/10.1161/01.str.31.9.2245
https://doi.org/10.1161/01.str.31.9.2245
Autor:
Toshio Asano, Ichiro Ikegaki, Yoshio Suzuki, Shin'ichi Satoh, Masato Shibuya, Yasuhiro Yamamoto, Yoshinori Toshima
Publikováno v:
Journal of Clinical Neuroscience. 6:394-399
We examined the possible prophylactic potential of fasudil, a protein kinase inhibitor, on the development of endothelial injury and neutrophil infiltration after subarachnoid haemorrhage (SAH). Using the two haemorrhage canine model, fasudil (3 mg/k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e42041c40bf238f9c6767ecbeff3ab9
https://doi.org/10.1016/s0967-5868(99)90034-6
https://doi.org/10.1016/s0967-5868(99)90034-6
Autor:
Yoshinori Toshima, Ichiro Ikegaki, Yoshio Suzuki, Toshio Asano, Masato Shibuya, Shin'ichi Satoh
Publikováno v:
Life Sciences. 61:1371-1377
To determine the pathogenetic mechanism underlying the maintenance of arterial narrowing during the chronic phase of cerebral vasospasm caused by subarachnoid hemorrhage (SAH), we examined the effect of ozagrel, a thromboxane A2 (TXA2) synthetase inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7846298f2cf0c166df5ccd18684c35d
https://doi.org/10.1016/s0024-3205(97)00682-6
https://doi.org/10.1016/s0024-3205(97)00682-6
Publikováno v:
European Journal of Pharmacology. 262:27-31
We have developed a model whereby the middle cerebral artery in an experimental animal can be occluded by a photochemical reaction between rose bengal and green light. This causes endothelial injury followed by platelet adhesion, aggregation and form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d510bb83fb89b29e2e3dde9a39a4c0
https://doi.org/10.1016/0014-2999(94)90024-8
https://doi.org/10.1016/0014-2999(94)90024-8
Autor:
Ichiro Ikegaki, Yoshinori Toshima, Koh Kawasaki, Toshio Asano, Shunsuke Tawara, Shin'ichi Satoh, Minoru Seto, Yasuo Sasaki, Kazuo Yano, Tsuyoshi Hattori
Publikováno v:
European journal of pharmacology. 594(1-3)
Evidence that Rho-kinase is involved in cerebral infarction has accumulated. However, it is uncertain whether Rho-kinase is activated in the brain parenchyma in cerebral infarction. To answer this question, we measured Rho-kinase activity in the brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77111c34afb5a890e7196929fb36c056
https://pubmed.ncbi.nlm.nih.gov/18703046
https://pubmed.ncbi.nlm.nih.gov/18703046
Publikováno v:
Brain research. 1193
The aim of this study was to investigate the influence of delayed Rho-kinase inhibition with fasudil on second ischemic injury in a rat cerebral thrombosis model. Cerebral ischemia was induced in rats by injecting 150 mug of sodium laurate into the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99694f9601dc898df7ad31e200061be3
https://pubmed.ncbi.nlm.nih.gov/18187127
https://pubmed.ncbi.nlm.nih.gov/18187127
Publikováno v:
Brain research. 1128(1)
The neuroprotective potential and therapeutic time window for fasudil, a Rho-kinase inhibitor (RKI), were evaluated for delayed neuronal death in gerbils. A preliminary screening was done on fasudil, ozagrel, and edaravone using a single administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81173d702319f41637619860b3d51db5
https://pubmed.ncbi.nlm.nih.gov/17123488
https://pubmed.ncbi.nlm.nih.gov/17123488
Publikováno v:
The Journal of veterinary medical science. 58(1)
The olfactory organs are equipped with their own associated glands, Bowman's glands (BG) of the olfactory epithelium (OE), and Jacobson's glands (JG) of the vomeronasal organ (VNO). Histology and ultrastructure of these glands in the adult were inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0033753081ac0c0efcfd4b43c821ae8d
https://pubmed.ncbi.nlm.nih.gov/8645751
https://pubmed.ncbi.nlm.nih.gov/8645751