Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Yoshinori Satomi"'
Publikováno v:
Cell & Bioscience, Vol 9, Iss 1, Pp 1-7 (2019)
Abstract Background Senescence is a well-known risk factor for several diseases, such as neurodegenerative disorders. Therefore, studies exploring the mechanisms underlying aging are expected to guide the discovery of novel drug targets and biomarker
Externí odkaz:
https://doaj.org/article/a03b327b77054a65912b955c32ab9074
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Purpose: We previously confirmed its anti-atherosclerotic effects by pre-treatment with compound-326, a selective delta-5 desaturase (D5D) inhibitor, in Western diet-fed ApoE knockout mice. In the present study, we evaluated effects of compound-326 i
Externí odkaz:
https://doaj.org/article/8609ef8b9da14aee848b87bb5cb14386
Autor:
Takatsugu Okegawa, Megumi Morimoto, Satoru Nishizawa, Satoshi Kitazawa, Kohei Honda, Hideo Araki, Toshiya Tamura, Ayumi Ando, Yoshinori Satomi, Kikuo Nutahara, Takahito Hara
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 31-38 (2017)
Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation of the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated in kidney cancer. Howeve
Externí odkaz:
https://doaj.org/article/650cdfe259ab4445ad501dcba0967819
Autor:
Kosuke Saito, Kotaro Hattori, Tomohiro Andou, Yoshinori Satomi, Masamitsu Gotou, Hiroyuki Kobayashi, Shinsuke Hidese, Hiroshi Kunugi
Publikováno v:
Metabolites, Vol 10, Iss 5, p 185 (2020)
Cerebrospinal fluid (CSF) metabolites reflect biochemical diffusion/export from the brain and possibly serve as biomarkers related to brain disease severity, pathophysiology, and therapeutic efficacy/toxicity. Metabolomic studies using blood matrices
Externí odkaz:
https://doaj.org/article/a65381c5cf6d4e2c965db89656e9f80e
Autor:
Kazumi Take, Taisuke Mochida, Toshiyuki Maki, Yoshinori Satomi, Megumi Hirayama, Masanori Nakakariya, Nobuyuki Amano, Ryutaro Adachi, Kenjiro Sato, Tomoyuki Kitazaki, Shiro Takekawa
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150976 (2016)
Monoacylglycerol O-acyltransferase 2 (MGAT2) catalyzes the synthesis of diacylglycerol (DG), a triacylglycerol precursor and potential peripheral target for novel anti-obesity therapeutics. High-throughput screening identified lead compounds with MGA
Externí odkaz:
https://doaj.org/article/c8df05438cd04ac5a4bafa334ec8568d
Autor:
Shota Ikeda, Ayumi Ando, Shuichi Takagahara, Yoshinori Satomi, Shigekazu Itokawa, Hideo Suzuki, Hiromi Shinohara, Takuya Fujimoto, Takeshi Yamamoto, Kazuki Kubo
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:290-298
Delta-5 desaturase (D5D), encoded by fatty acid desaturase 1 (Fads1), is the rate-limiting enzyme for the conversion from dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) in the ω-6 polyunsaturated fatty acid pathway. Several AA-derived eico
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Purpose: We previously confirmed its anti-atherosclerotic effects by pre-treatment with compound-326, a selective delta-5 desaturase (D5D) inhibitor, in Western diet-fed ApoE knockout mice. In the present study, we evaluated effects of compound-326 i
Publikováno v:
Journal of Biochemistry. Feb2018, Vol. 163 Issue 2, p113-121. 9p.
Autor:
Yoshinori Satomi, Hiroyuki Kobayashi, Tomohiro Andou, Kosuke Saito, Hiroshi Kunugi, Shinsuke Hidese, Kotaro Hattori, Masamitsu Gotou
Publikováno v:
Metabolites
Volume 10
Issue 5
Metabolites, Vol 10, Iss 185, p 185 (2020)
Volume 10
Issue 5
Metabolites, Vol 10, Iss 185, p 185 (2020)
Cerebrospinal fluid (CSF) metabolites reflect biochemical diffusion/export from the brain and possibly serve as biomarkers related to brain disease severity, pathophysiology, and therapeutic efficacy/toxicity. Metabolomic studies using blood matrices
Autor:
Yuichiro Eguchi, Yoshinori Satomi, Megumi Hirayama, Tatsuya Ando, Hirokazu Takahashi, Yuko Nagaoki, Takaomi Kessoku, Takeharu Yamanaka, Yuichiro Amano, Masayoshi Kage, Yusuke Saigusa, Yuji Ogawa, Osamu Isono, Hidenori Kamiguchi, Yasushi Honda, Kento Imajo, Masato Yoneda, Shinji Ogawa, Takashi Nakahara, Kazuaki Chayama, Wataru Tomeno, Satoshi Oeda, Atsushi Nakajima, Shinichi Aishima, Satoru Saito, Hideyuki Hyogo, Takashi Kobayashi, Hiroshi Nagabukuro
Publikováno v:
Hepatology research : the official journal of the Japan Society of HepatologyReferences. 50(8)
AIM Liver biopsy is still required for the diagnosis of hepatocellular ballooning and inflammation, which are important histological features of non-alcoholic steatohepatitis. We undertook this multicenter, cross-sectional study to identify novel blo