Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yoshinori Ikeura"'
Autor:
Naoki Tarui, Junya Shirai, Tadatoshi Hashimoto, Nobuhiro Inatomi, Shinji Morimoto, Keiko Ishigami, Makiko Kawamoto, Satoshi Okanishi, Akio Imanishi, Hironobu Maezaki, Hideyuki Sugiyama, Izumi Kamo, Shiho Matsumoto, Yasuharu Yamamoto, Yoshinori Ikeura
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:962-977
The synthesis and biological evaluation of a series of novel 3-phenylpiperidine-4-carboxamide derivatives are described. These compounds are generated by hybridization of the substructures from two types of tachykinin NK 1 receptor antagonists. Compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9810fd4c6a4c354796c1b6a3db62b0
https://doi.org/10.1016/j.bmc.2011.11.048
https://doi.org/10.1016/j.bmc.2011.11.048
Autor:
Eikoh Imamiya, Masayoshi Yamaoka, Junya Shirai, Minoru Nakamura, Tadatoshi Hashimoto, Yoshinori Ikeura, Naoki Tarui
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5175-5182
A series of novel 3-benzhydryl-4-piperidone derivatives were identified as potent tachykinin neurokinin-1 (NK(1)) receptor antagonists. An efficient and versatile synthesis of this series was achieved with a coupling reaction of 1-benzylpiperidones w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f9f66870226ae6028f44f703209821
https://doi.org/10.1016/j.bmc.2011.07.014
https://doi.org/10.1016/j.bmc.2011.07.014
Autor:
Toshimasa Tanaka, Hiroyuki Kimura, Satoshi Sogabe, Hideyuki Sugiyama, Tomohiro Kawamoto, Terufumi Takagi, Masato Yoshida, Kouji Mori, Hideyuki Oki, Yoshinori Ikeura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:613-624
As a novel class of IKKbeta inhibitors, a series of tricyclic furan derivatives was designed and synthesized based on the structure of known thiophene IKKbeta inhibitors. Among the various fused furan derivatives synthesized, a benzothieno[3,2-b]fura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1203322812f2c7a43865103947ca37f9
https://doi.org/10.1248/cpb.55.613
https://doi.org/10.1248/cpb.55.613
Publikováno v:
Tetrahedron. 60:4481-4490
A series of novel N-benzylcarboxamide derivatives of bicyclic compounds, 3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one and 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one, were synthesized by cyclization of N-benzyl-2-chloro-N-(2-hydroxyethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::642b9573721bd9c4ba09639d36a9a81f
https://doi.org/10.1016/j.tet.2004.01.097
https://doi.org/10.1016/j.tet.2004.01.097
Autor:
Yoshinori Ikeura
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :SY13-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e95426bce06e7ccea611fe4a5536c9b2
https://doi.org/10.1254/jpssuppl.wcp2018.0_sy13-2
https://doi.org/10.1254/jpssuppl.wcp2018.0_sy13-2
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:925-931
Irritable bowel syndrome (IBS) is a common disorder mainly characterized by altered bowel habits and visceral pain. In this study, we investigated the role of tachykinin NK1 receptors in the visceral pain response (abdominal muscle contraction) cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc1c5fa583b4322eeeda802bf33e312
https://doi.org/10.1124/jpet.300.3.925
https://doi.org/10.1124/jpet.300.3.925
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:865-870
Microbial conversion of deuterium-labelled TAK-637 ((aR,9S)-[10,10,11, 11-2H4]-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-(4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione, 1) was carried out using Strepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e4f40be7e726c77fa431ddae8cc1a0f
https://doi.org/10.1002/jlcr.513
https://doi.org/10.1002/jlcr.513
Autor:
Takayuki Doi, Takenori Ishimaru, Kiyota Y, Toshimasa Tanaka, Masaki Ogino, Yoshinori Ikeura, Izumi Kamo, Hideaki Natsugari, Shinji Morimoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:1642-1652
Various N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl heterocycles (1, 2 and 3) modified at rings A and B in the isoquinolone (1a) and pyrido[3,4-b]pyridine (2a) nuclei were prepared and evaluated for NK 1 receptor antagonistic activities. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4809642e2b5e5d695054878e37c9b061
https://doi.org/10.1248/cpb.45.1642
https://doi.org/10.1248/cpb.45.1642
Autor:
Izumi Kamo, Takayuki Doi, O. Saga, Toshimasa Tanaka, Yutaka Kiyota, Hideo Shirafuji, Hideaki Natsugari, Takenori Ishimaru, Yuji Ishichi, Yoshinori Ikeura
Publikováno v:
Journal of Medicinal Chemistry. 38:3106-3120
A series of 4-phenylisoquinolone derivatives were synthesized and evaluated for NK1 (substance P) antagonist activity. Highly potent antagonists, 4-phenyl-3-isoquinolone-N-benzylcarboxamides (11), were discovered from the structure-activity relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98325c42e302de564455962217cc12fc
https://doi.org/10.1021/jm00016a014
https://doi.org/10.1021/jm00016a014
Autor:
Junya Shirai, Tadatoshi Hashimoto, Yasuharu Yamamoto, Izumi Kamo, Makiko Kawamoto, Takeshi Yoshikawa, Naoki Tarui, Yoshinori Ikeura, Masayuki Yamashita
Publikováno v:
Bioorganicmedicinal chemistry. 19(21)
We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK(1) receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45168c24426002ddc7e8ed948f5d5447
https://pubmed.ncbi.nlm.nih.gov/21944973
https://pubmed.ncbi.nlm.nih.gov/21944973