Výsledky vyhledávání - "Yoshinori Hamajima"

REPRODUCTION STUDIES OF VP 16-213 (V) : Intravenous administration to rats prior to and in the early stages of pregnancy

Autor: Norimitsu TAKAHASHI, Shuichi KAI, Hisashi KOHMURA, Katsumi ISHIKAWA, Takashi TANAKA, Kohji KUROYANAGI, Yoshinori HAMAJIMA, Satoshi OHTA, Toshihito KADOTA, Shigeo KAWANO, Keiko OHTA, Yukako TAKEUCHI

Publikováno v: The Journal of Toxicological Sciences. 11:263-279

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered intravenously to male Crj : CD (Sprague-Dawley) rats for 61 days and to female rats of the same strain for 14 days prior to mating at dose levels of 0.05, 0.2 and 0.8 mg/kg/day.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9b25132c19aec5948942ad8b399c5
https://doi.org/10.2131/jts.11.supplementi_263

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TOXICITY STUDIES OF VP 16-213 (V) Intravenous three-month toxicity in rats

Autor: Katsumi Ishikawa, Kohji Kuroyanagi, Satoshi Ohta, Hirotaka Chikazawa, Yukako Takeuchi, Hisashi Kohmura, Norimitsu Takahashi, Toshihito Kadota, Shigeo Kawano, Keiko Ohta, Shuichi Kai, Yoshinori Hamajima

Publikováno v: The Journal of Toxicological Sciences. 11:123-161

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered intravenously to Crj : CD (Sprague-Dawley) rats of both sexes at dose levels of 0.05, 0.15, 0.5 and 1.5 mg/kg/day for three months with the object of examining its toxicity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e523f1c382b6fdc6ad6bea40fe8c25ec
https://doi.org/10.2131/jts.11.supplementi_123

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TOXICITY STUDIES OF VP 16-213 (II) : Oral one-month subacute toxicity in rats

Autor: Katsumi Ishikawa, Hisashi Kohmura, Satoshi Ohta, Yoshinori Hamajima, Keiko Ohta, Norimitsu Takahashi, Kohji Kuroyanagi, Shigeo Kawano, Shuichi Kai, Toshihito Kadota

Publikováno v: The Journal of Toxicological Sciences. 11:17-49

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered orally to Crj : CD (Sprague-Dawley) rats of both sexes at dose levels of 3, 10, 30 and 100 mg/kg/day for one month with the object of examining its subacute toxicity and the rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43602d8ea2786d35665d40d5c405150
https://doi.org/10.2131/jts.11.supplementi_17

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REPRODUCTION STUDIES OF VP 16-213 (II) : Oral administration to rats during the period of fetal organogenesis

Autor: Kohji Kuroyanagi, Toshihito Kadota, Shigeo Kawano, Katsumi Ishikawa, Norimitsu Takahashi, Shuichi Kai, Keiko Ohta, Satoshi Ohta, Hisashi Kohmura, Yoshinori Hamajima

Publikováno v: The Journal of Toxicological Sciences. 11:195-225

VP16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered orally to pregnant Crj: CD (Sprague-Dawley) rats from day 7 through 17 of gestation at dose levels of 1, 3 and 10 mg/kg/day. The summarized results obtained are as follows: 1. VP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b32e859bfe5b673338f54611bbf4d23
https://doi.org/10.2131/jts.11.supplementi_195

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TOXICITY STUDIES OF VP16-213 (IV) : Intravenous one-month subacute toxicity in rats

Autor: Satoshi Ohta, Yoshinori Hamajima, Shuichi Kai, Katsumi Ishikawa, Shigeo Kawano, Hisashi Kohmura, Toshihito Kadota, Norimitsu Takahashi, Keiko Ohta, Kohji Kuroyanagi

Publikováno v: The Journal of Toxicological Sciences. 11:89-122

VP16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered intravenously to Crj : CD (Sprague-Dawley) rats of both sexes at dose levels of 0.15, 0.50, 1.5 and 4.5 mg/kg/day for one month with the object of examining its subacute toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf030267eca1ce9402c4bee61caf54e
https://doi.org/10.2131/jts.11.supplementi_89

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[Toxicity studies of VP 16-213 (III)--Oral six-month chronic toxicity in rats]

Autor: Katsumi Ishikawa, Yoshinori Hamajima, Kohji Kuroyanagi, Satoshi Ohta, Norimitsu Takahashi, Toshihito Kadota, Shigeo Kawano, Keiko Ohta, Hisashi Kohmura, Shuichi Kai