Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yoshinori Fukazawa"'
Autor:
Françoise Haeseleer, Yoshinori Fukazawa, Haesun Park, Benjamin Varco-Merth, Blake J. Rust, Jeremy V. Smedley, Karsten Eichholz, Christopher W. Peterson, Rosemarie Mason, Hans-Peter Kiem, Mario Roederer, Louis J. Picker, Afam A. Okoye, Lawrence Corey
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 304-319 (2021)
Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs. Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate th
Externí odkaz:
https://doaj.org/article/2e4204042ab849e8adedcd5d6bbb820e
Autor:
Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M.A. Cameron, Timothy J. Henrich, Afam A. Okoye
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mT
Externí odkaz:
https://doaj.org/article/0626fdc3092c4cc489640700d2cf76b5
Autor:
Afam A Okoye, Rémi Fromentin, Hiroshi Takata, Jessica H Brehm, Yoshinori Fukazawa, Bryan Randall, Marion Pardons, Vincent Tai, Jun Tang, Jeremy Smedley, Michael Axthelm, Jeffrey D Lifson, Louis J Picker, David Favre, Lydie Trautmann, Nicolas Chomont
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010245 (2022)
Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption in vitro. However, significant toxicity risks and the lack of evidence supporting their acti
Externí odkaz:
https://doaj.org/article/010dc74613b6426081cb5b18f4918266
Autor:
Fredrik Barrenäs, Scott G Hansen, Lynn Law, Connor Driscoll, Richard R Green, Elise Smith, Jean Chang, Inah Golez, Taryn Urion, Xinxia Peng, Leanne Whitmore, Daniel Newhouse, Colette M Hughes, David Morrow, Kurt T Randall, Andrea N Selseth, Julia C Ford, Roxanne M Gilbride, Bryan E Randall, Emily Ainslie, Kelli Oswald, Rebecca Shoemaker, Randy Fast, William J Bosche, Michael K Axthelm, Yoshinori Fukazawa, George N Pavlakis, Barbara K Felber, Slim Fourati, Rafick-Pierre Sekaly, Jeffrey D Lifson, Jan Komorowski, Ewelina Kosmider, Danica Shao, Wenjun Song, Paul T Edlefsen, Louis J Picker, Michael Gale
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009278 (2021)
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68-1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of h
Externí odkaz:
https://doaj.org/article/cd57c9263ff449bb8bd672c756c1208a
Autor:
Eichholz, Karsten1, Yoshinori Fukazawa2, Peterson, Christopher W.3, Francoise, Francoise1,4,5, Medina, Manuel2, Hoffmeister, Shelby2, Duel, Derick M.1,2, Varco-Merth, Benjamin D.2, Dross, Sandra6,7, Haesun Park2, Labriola, Caralyn S.2, Axthelm, Michael K.2, Murnane, Robert D.6, Smedley, Jeremy V.2, Lei Jin1, Jiaxin Gong1, Rust, Blake J.3, Fuller, Deborah H.6,7, Kiem, Hans-Peter1,3,5, Picker, Louis J.2
Publikováno v:
Journal of Clinical Investigation. 4/1/2024, Vol. 134 Issue 7, p1-14. 14p.
Autor:
Jeremy V. Smedley, Rachele M. Bochart, Miranda Fischer, Heidi Funderburgh, Vanessa Kelly, Hugh Crank, Kim Armantrout, Oriene Shiel, Mitchell Robertson‐LeVay, Nikki Sternberger, Brian Schmaling, Sheila Roberts, Vicki Sekiguchi, Michael Reusz, Tiah Schwartz, Kimberly A. Meyer, Gabriela Webb, Roxanne M. Gilbride, Nicholas Dambrauskas, Daniela Andrade, Matthew Wood, Caralyn Labriola, Michael Axthelm, Nina Derby, Ben Varco‐Merth, Yoshinori Fukazawa, Scott Hansen, Jonah B. Sacha, Donald L. Sodora, D. Noah Sather
Publikováno v:
Journal of Medical Primatology. 51:270-277
Identification of lymph nodes (LNs) draining a specific site or in obese macaques can be challenging.Indocyanine Green (ICG) was administered intradermal (ID), intramuscular, in the oral mucosa, or subserosal in the colon followed by Near Infrared (N
Autor:
Rebecca L. Skalsky, Scott W. Wong, Derick M. Duell, Lina Gao, Richard Lum, Michael K. Axthelm, Audrie L. Konfe, Maren Q. DeGottardi, Afam A. Okoye, Devin N. Fachko, Mukta Vaidya, He Li, Byung Park, Louis J. Picker, Yoshinori Fukazawa, Chike O. Abana, Jeffrey D. Lifson, Anne D. Lewis
Publikováno v:
J Immunol
Although IL-15 has been implicated in the pathogenic hyperimmune activation that drives progressive HIV and SIV infection, as well as in the generation of HIV/SIV target cells, it also supports NK and T cell homeostasis and effector activity, potenti
Autor:
Taryn Urion, Connor B. Driscoll, Rebecca Shoemaker, Emily Ainslie, Rafick Pierre Sekaly, Slim Fourati, Yoshinori Fukazawa, Lynn Law, Richard Green, Fredrik Barrenäs, Ewelina Kosmider, Randy Fast, David Morrow, Paul T. Edlefsen, Kurt T. Randall, Michael K. Axthelm, Andrea N. Selseth, William J. Bosche, Julia C. Ford, Jeffrey D. Lifson, Jan Komorowski, Barbara K. Felber, Jean Chang, Elise Smith, Leanne S. Whitmore, Bryan E. Randall, Danica Shao, Kelli Oswald, Michael Gale, Colette M. Hughes, Inah Golez, George N. Pavlakis, Scott G. Hansen, Daniel J. Newhouse, Xinxia Peng, Louis J. Picker, Wenjun Song, Roxanne M. Gilbride
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009278 (2021)
PLoS Pathogens
PLoS Pathogens
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68–1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification
Autor:
Paul T. Edlefsen, Brandon F. Keele, Louis J. Picker, Alejandra Marenco, Jeremy Smedley, Jacob D. Estes, Kathleen Busman-Sahay, Roxanne M. Gilbride, Haesun Park, Miles P. Davenport, Mykola Pinkevych, Michael Nekorchuk, Yoshinori Fukazawa, Afam A. Okoye, Benjamin Varco-Merth, Morgan Chaunzwa, Andrea N. Selseth, Hannah Behrens, Michael K. Axthelm, Jeffery D. Lifson, Jason Shao, Scott G. Hansen, Derick D. Duell, Romas Geleziunas
Publikováno v:
J Clin Invest
To define the contribution of CD8(+) T cell responses to control of SIV reactivation during and following antiretroviral therapy (ART), we determined the effect of long-term CD8(+) T cell depletion using a rhesusized anti-CD8β monoclonal antibody on
Autor:
Rosemarie D. Mason, Lawrence Corey, Louis J. Picker, Blake J. Rust, Karsten Eichholz, Françoise Haeseleer, Benjamin Varco-Merth, Yoshinori Fukazawa, Haesun Park, Jeremy Smedley, Hans-Peter Kiem, Afam A. Okoye, Christopher W. Peterson, Mario Roederer
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 304-319 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 304-319 (2021)
Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs. Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate th