Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Yoshinobu Toda"'
Autor:
Koji Yamasaki, Shoichiro Mukai, Takahiro Nagai, Kozue Nakahara, Masato Fujii, Naoki Terada, Akinobu Ohno, Yuichiro Sato, Yoshinobu Toda, Hiroaki Kataoka, Toshiyuki Kamoto
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3708 (2018)
Hepatocyte growth factor (HGF) plays an important role in cancer progression via phosphorylation of MET (c-met proto-oncogene product, receptor of HGF). HGF-zymogen (pro-HGF) must be processed for activation by HGF activators including matriptase, wh
Externí odkaz:
https://doaj.org/article/ad6974bde1184b80850c46ab13b176ad
Autor:
Koji Yamasaki, Shoichiro Mukai, Satoru Sugie, Takahiro Nagai, Kozue Nakahara, Toyoharu Kamibeppu, Hiromasa Sakamoto, Noboru Shibasaki, Naoki Terada, Yoshinobu Toda, Hiroaki Kataoka, Toshiyuki Kamoto
Publikováno v:
Cancers, Vol 10, Iss 6, p 190 (2018)
MET, a c-met proto-oncogene product and hepatocyte growth factor (HGF) receptor, is known to play an important role in cancer progression, including bone metastasis. In a previous study, we reported increased expression of MET and matriptase, a novel
Externí odkaz:
https://doaj.org/article/f870ee5287214ec9a959d47af335afce
Autor:
Yuki Muraoka, Hanako Ohashi Ikeda, Noriko Nakano, Masanori Hangai, Yoshinobu Toda, Keiko Okamoto-Furuta, Haruyasu Kohda, Mineo Kondo, Hiroko Terasaki, Akira Kakizuka, Nagahisa Yoshimura
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36135 (2012)
BACKGROUND: Recently, a transgenic rabbit with rhodopsin Pro 347 Leu mutation was generated as a model of retinitis pigmentosa (RP), which is characterized by a gradual loss of vision due to photoreceptor degeneration. The purpose of the current stud
Externí odkaz:
https://doaj.org/article/e753dfca76dc4f969ee5408b74c0c873
Autor:
Toshi Menju, Shigeru Hashimoto, Ari Hashimoto, Yutaro Otsuka, Haruka Handa, Eiji Ogawa, Yoshinobu Toda, Hiromi Wada, Hiroshi Date, Hisataka Sabe
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25301 (2011)
Overexpression of Her2/ErbB2/Neu in cancer is often correlated with recurrent distant metastasis, although the mechanism still remains largely elusive. We have previously shown that EGFR, when tyrosine-phosphorylated, binds to GEP100/BRAG2 to activat
Externí odkaz:
https://doaj.org/article/09b6929342a64a12b3c127507a79f81a
Autor:
Ari Hashimoto, Shigeru Hashimoto, Ryo Ando, Kosuke Noda, Eiji Ogawa, Hirokazu Kotani, Mayumi Hirose, Toshi Menju, Masaki Morishige, Toshiaki Manabe, Yoshinobu Toda, Susumu Ishida, Hisataka Sabe
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23359 (2011)
Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy.Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis. In this pathway, Arf6 is
Externí odkaz:
https://doaj.org/article/76a0249c1774460ca25c598d58adea85
Autor:
Chikashi Terao, Koichiro Ohmura, Masaki Katayama, Meiko Takahashi, Miki Kokubo, Gora Diop, Yoshinobu Toda, Natsuki Yamamoto, Human Disease Genomics Working Group, Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium, Reiko Shinkura, Masakazu Shimizu, Ivo Gut, Simon Heath, Inga Melchers, Toshiaki Manabe, Mark Lathrop, Tsuneyo Mimori, Ryo Yamada, Fumihiko Matsuda
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20457 (2011)
Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a gen
Externí odkaz:
https://doaj.org/article/5e8028aa39dd43a694a15c17d10f8e4f
Autor:
Masato Fujii, Kozue Nakahara, Toshiyuki Kamoto, Yoshinobu Toda, Akinobu Ohno, Koji Yamasaki, Naoki Terada, Yuichiro Sato, Hiroaki Kataoka, Shoichiro Mukai, Takahiro Nagai
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3708 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Hepatocyte growth factor (HGF) plays an important role in cancer progression via phosphorylation of MET (c-met proto-oncogene product, receptor of HGF). HGF-zymogen (pro-HGF) must be processed for activation by HGF activators including matriptase, wh
Autor:
Norio Yamamoto, Munehiro Uemura, Kazuo Kinoshita, Ryo Asato, Yukari Hattori, Yoshinobu Toda, Taichiro Nonaka, Motonobu Nakamura, Nagahiro Minato, Hiroshi Hiai, Kazuhisa Bessho
Publikováno v:
Journal of Clinical Investigation. 126:1367-1382
Most skin cancers develop as the result of UV light–induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected
Autor:
Hiroaki Kataoka, Noboru Shibasaki, Takahiro Nagai, Yoshinobu Toda, Shoichiro Mukai, Naoki Terada, Hiromasa Sakamoto, Koji Yamasaki, Satoru Sugie, Toshiyuki Kamoto, Kozue Nakahara, Toyoharu Kamibeppu
Publikováno v:
Cancers
Volume 10
Issue 6
Cancers, Vol 10, Iss 6, p 190 (2018)
Volume 10
Issue 6
Cancers, Vol 10, Iss 6, p 190 (2018)
MET, a c-met proto-oncogene product and hepatocyte growth factor (HGF) receptor, is known to play an important role in cancer progression, including bone metastasis. In a previous study, we reported increased expression of MET and matriptase, a novel
Autor:
Hisashi Kohno, Kohki Okada, Hiroshi Nakase, Masaki Ikemoto, Hiroshi Itoh, Fumihiko Nakamura, Souichi Adachi, Mayu Takeda, Satoshi Arai, Yoshinobu Toda
Publikováno v:
Biochemical and Biophysical Research Communications. 456:415-420
The development of ulcerative colitis (UC) is closely associated with abnormally functioning macrophages. Rat S100A8 (r-S100A8) and r-S100A9 (S100 proteins) is abundantly expressed in immune cells of myeloid origin, macrophages; however, it remains u