Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yoshinobu KON"'
Autor:
Yoshinobu Konishi, Kenta Terai
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-7 (2023)
Abstract Inflammation can contribute to the development and progression of cancer. The inflammatory responses in the tumor microenvironment are shaped by complex sequences of dynamic intercellular cross-talks among diverse types of cells, and recapit
Externí odkaz:
https://doaj.org/article/463ac4176ec44e41ac529d185a06bf2f
Autor:
Yoshinobu Kondo, Hiroshi Yatsuya, Atsuhiko Ota, Shoji Matsumoto, Akihiro Ueda, Hirohisa Watanabe, Hideaki Toyoshima
Publikováno v:
Journal of Epidemiology, Vol 33, Iss 1, Pp 23-30 (2023)
Background: No studies have examined the associations between adult height and ischemic stroke subtypes. Methods: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intrace
Externí odkaz:
https://doaj.org/article/a6b06133ef61481cba96a703f82a9529
Autor:
Ryota Maeda, Junso Fujita, Yoshinobu Konishi, Yasuhiro Kazuma, Hiroyuki Yamazaki, Itsuki Anzai, Tokiko Watanabe, Keishi Yamaguchi, Kazuki Kasai, Kayoko Nagata, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Kotaro Shirakawa, Kei Sato, Fumiaki Makino, Yoshiharu Matsuura, Tsuyoshi Inoue, Akihiro Imura, Keiichi Namba, Akifumi Takaori-Kondo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
A panel of nanobodies are presented that can detect the spike proteins of five SARS-CoV-2 variants of concern and structural analyses show that one clone targets conserved epitopes on the receptor-binding domain and contacts the N-terminal domain.
Externí odkaz:
https://doaj.org/article/ebff1ac040bc4897b219b41bbbf0ca49
Autor:
Yasuhiro Kazuma, Kotaro Shirakawa, Yusuke Tashiro, Hiroyuki Yamazaki, Ryosuke Nomura, Yoshihito Horisawa, Suguru Takeuchi, Emani Stanford, Yoshinobu Konishi, Hiroyuki Matsui, Tadahiko Matsumoto, Fumiko Tanabe, Ryo Morishita, Shinji Ito, Akifumi Takaori-Kondo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract DNA cytosine deaminase APOBEC3B (A3B) is an endogenous source of mutations in many human cancers, including multiple myeloma. A3B proteins form catalytically inactive high molecular mass (HMM) complexes in nuclei, however, the regulatory mec
Externí odkaz:
https://doaj.org/article/7d400becc0de46478b6b4de3e4025404
Autor:
Sho Kinguchi, Hiromichi Wakui, Yuzuru Ito, Yoshinobu Kondo, Kengo Azushima, Uru Osada, Tadashi Yamakawa, Tamio Iwamoto, Jun Yutoh, Toshihiro Misumi, Gen Yasuda, Taishi Yoshii, Kotaro Haruhara, Yusuke Kobayashi, Takeharu Yamanaka, Yasuo Terauchi, Kouichi Tamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract We investigated the impact of basal dietary sodium intake on the dapagliflozin-induced changes in albuminuria and blood pressure (BP) measured at home in patients with diabetic kidney disease (DKD).This was a secondary analysis of the Y-AIDA
Externí odkaz:
https://doaj.org/article/cdddeddde1a34fc99cf696f1e8399867
Autor:
Hirotatsu Nakaguchi, Yoshinobu Kondo, Mayu Kyohara, Hiromi Konishi, Koji Oiwa, Yasuo Terauchi
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 6, Pp 1542-1550 (2020)
Abstract Aims/Introduction Liraglutide and empagliflozin suppress cardiovascular events. However, reports on their long‐term combined use with insulin therapy or direct comparisons of these drugs are limited. Materials and Methods This open‐label
Externí odkaz:
https://doaj.org/article/c810c0ec5cb94520ae3dff807730d3cb
Autor:
Hiroshi Ichise, Shoko Tsukamoto, Tsuyoshi Hirashima, Yoshinobu Konishi, Choji Oki, Shinya Tsukiji, Satoshi Iwano, Atsushi Miyawaki, Kenta Sumiyama, Kenta Terai, Michiyuki Matsuda
Publikováno v:
eLife, Vol 11 (2022)
Natural killer (NK) cells lyse invading tumor cells to limit metastatic growth in the lung, but how some cancers evade this host protective mechanism to establish a growing lesion is unknown. Here, we have combined ultra-sensitive bioluminescence ima
Externí odkaz:
https://doaj.org/article/0181e79d5876476faaf234e34d7941c6
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0262831 (2022)
Patients with type 2 diabetes who have cardiovascular disease and are receiving empagliflozin have a lower rate of primary composite cardiovascular outcomes. In contrast, glimepiride increases cardiovascular hospitalization when combined with metform
Externí odkaz:
https://doaj.org/article/f576ac54d603487cabf9ce6411bbf514
Autor:
Sho Kinguchi, Hiromichi Wakui, Yuzuru Ito, Yoshinobu Kondo, Kengo Azushima, Uru Osada, Tadashi Yamakawa, Tamio Iwamoto, Jun Yutoh, Toshihiro Misumi, Kazutaka Aoki, Gen Yasuda, Taishi Yoshii, Takayuki Yamada, Syuji Ono, Tomoko Shibasaki-Kurita, Saho Hosokawa, Kazuki Orime, Masaaki Hanaoka, Hiroto Sasaki, Kohji Inazumi, Taku Yamada, Ryu Kobayashi, Kohji Ohki, Kotaro Haruhara, Yusuke Kobayashi, Takeharu Yamanaka, Yasuo Terauchi, Kouichi Tamura
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-16 (2019)
Abstract Background The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) and albuminuria. Methods We con
Externí odkaz:
https://doaj.org/article/50e7b7e490e0465aaec1b0fc91a5c964
Autor:
Marina Harada, Tadashi Yamakawa, Rie Kashiwagi, Akeo Ohira, Mai Sugiyama, Yasuyuki Sugiura, Yoshinobu Kondo, Yasuo Terauchi
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255147 (2021)
Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed. Members of the angiopoietin-like protein (ANGPTL) f
Externí odkaz:
https://doaj.org/article/d9c69409ed46486fa6783030fbcf8d88