Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Yoshinari Miyata"'
Autor:
Xiaobo Wang, Mary P. Moore, Hongxue Shi, Yoshinari Miyata, Sara K. Donnelly, Daniel R. Radiloff, Ira Tabas
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101165- (2023)
Nonalcoholic steatohepatitis (NASH) is emerging as the most common cause of liver disease. Although many studies in mouse NASH models have suggested therapies, translation to humans is poor, with no approved drugs for NASH. One explanation may lie in
Externí odkaz:
https://doaj.org/article/05784e6569ad435ca672dd324341be8b
Autor:
Matthew Dent, Krystal Hamorsky, Thibaut Vausselin, Jean Dubuisson, Yoshinari Miyata, Yoshio Morikawa, Nobuyuki Matoba
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 185-198 (2021)
Background & Aims: Infection with hepatitis C virus (HCV) remains a major cause of morbidity and mortality worldwide despite the recent advent of highly effective direct-acting antivirals. The envelope glycoproteins of HCV are heavily glycosylated wi
Externí odkaz:
https://doaj.org/article/65b49c73e8674a7b9c1406a49a0e59fc
Autor:
John Koren, Yoshinari Miyata, Janine Kiray, John C. O'Leary, Lana Nguyen, Jianping Guo, Laura J. Blair, Xiaokai Li, Umesh K. Jinwal, Jin Q. Cheng, Jason E. Gestwicki, Chad A. Dickey
Publikováno v:
PLoS ONE, Vol 7, Iss 7 (2012)
Externí odkaz:
https://doaj.org/article/1a4147948bde4db09df2afc3e153f143
Autor:
John Koren, Yoshinari Miyata, Janine Kiray, John C O'Leary, Lana Nguyen, Jianping Guo, Laura J Blair, Xiaokai Li, Umesh K Jinwal, Jin Q Cheng, Jason E Gestwicki, Chad A Dickey
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35566 (2012)
MKT-077, a rhodacyanine dye, was shown to produce cancer specific cell death. However, complications prevented the use of this compound beyond clinical trials. Here we describe YM-1, a derivative of MKT-077. We found that YM-1 was more cytotoxic and
Externí odkaz:
https://doaj.org/article/5a1f2f7e12414802a13741110362ebfe
Autor:
Matthew T. N. Yarnall, Eleonora I. Ioannidi, Cian Schmitt-Ulms, Rohan N. Krajeski, Justin Lim, Lukas Villiger, Wenyuan Zhou, Kaiyi Jiang, Sofya K. Garushyants, Nathaniel Roberts, Liyang Zhang, Christopher A. Vakulskas, John A. Walker, Anastasia P. Kadina, Adrianna E. Zepeda, Kevin Holden, Hong Ma, Jun Xie, Guangping Gao, Lander Foquet, Greg Bial, Sara K. Donnelly, Yoshinari Miyata, Daniel R. Radiloff, Jordana M. Henderson, Andrew Ujita, Omar O. Abudayyeh, Jonathan S. Gootenberg
Publikováno v:
Nat Biotechnol
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We present programmable addition via site-specific targeting elements (PASTE), which u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f0141730000285cf08335780ce35c5
https://doi.org/10.1038/s41587-022-01527-4
https://doi.org/10.1038/s41587-022-01527-4
Autor:
Suguru Kato, Swapan Chowdhury, Jayaprakasam Bolleddula, Mihaela Plesescu, Yoshinari Miyata, Abhi Shah, Xiaochun Zhu
Publikováno v:
Drug Metabolism and Disposition. 48:934-943
The PXB-mouse is potentially a useful in vivo model to predict human hepatic metabolism and clearance. Four model compounds, [14C]desloratadine, [3H]mianserin, cyproheptadine, and [3H]carbazeran, all reported with disproportionate human metabolites,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ced06eca08636d58fdba47f17d4f460
https://doi.org/10.1124/dmd.120.000128
https://doi.org/10.1124/dmd.120.000128
Autor:
France Landry, Hong Shen, Yueping Zhang, Asako Uchiyama, Yoshinari Miyata, Yoshio Morikawa, Beth Joshi, Petia Shipkova
Publikováno v:
Bioanalysis. 14(5)
Background: The degree of human hepatocyte replacement in chimeric mice with humanized liver has previously been shown to correlate with human plasma albumin measurements. However, there are no reports that directly compare the remaining endogenous m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7acb87b8495e48708fd86106e84b473
https://pubmed.ncbi.nlm.nih.gov/35195037
https://pubmed.ncbi.nlm.nih.gov/35195037
Autor:
Krystal Teasley Hamorsky, Yoshio Morikawa, Thibaut Vausselin, Jean Dubuisson, Yoshinari Miyata, Matthew Dent, Nobuyuki Matoba
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 2020, ⟨10.1016/j.jcmgh.2020.08.009⟩
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2020, ⟨10.1016/j.jcmgh.2020.08.009⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 185-198 (2021)
Cellular and Molecular Gastroenterology and Hepatology, 2020, ⟨10.1016/j.jcmgh.2020.08.009⟩
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2020, ⟨10.1016/j.jcmgh.2020.08.009⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 185-198 (2021)
Background & Aims Infection with hepatitis C virus (HCV) remains a major cause of morbidity and mortality worldwide despite the recent advent of highly effective direct-acting antivirals. The envelope glycoproteins of HCV are heavily glycosylated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a77797ed0790198e94d645b7e2d73e5
https://hal.science/hal-02992405/document
https://hal.science/hal-02992405/document
Autor:
Yoshinari Miyata, Jeanne A. Stuckey, Joseph T Madak, Elyse Petrunak, Yanyan Han, Shuzo Tamura, Miao He, H. D. Hollis Showalter, Christine R. Cuthbertson, Duxin Sun, Nouri Neamati
Publikováno v:
J Med Chem
We pursued a structure-guided approach toward the development of improved dihydroorotate dehydrogenase (DHODH) inhibitors with the goal of forming new interactions between DHODH and the brequinar class of inhibitors. Two potential residues, T63 and Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8be5202d5d18ce2b324e60907e8fcc
https://doi.org/10.1021/acs.jmedchem.7b01862
https://doi.org/10.1021/acs.jmedchem.7b01862