Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Yoshinao Kobayashi"'
Autor:
Nils Becker, Niklas Franz, Akiko Eguchi, Alessa Wagner, Ramona Sturm, Helen Rinderknecht, Yoshinao Kobayashi, Motoh Iwasa, Birte Weber, Ingo Marzi, Borna Relja
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundExtracellular particles (EPs), particularly extracellular vesicles, play a crucial role in regulating various pathological mechanisms, including immune dysregulations post-trauma. Their distinctive expression of cell-specific markers and re
Externí odkaz:
https://doaj.org/article/a0bd187bbceb4c359f51fdb960ab14a5
Autor:
Akiko Eguchi, Motoh Iwasa, Minori Yamada, Yasuyuki Tamai, Ryuta Shigefuku, Hiroshi Hasegawa, Yoshifumi Hirokawa, Akinobu Hayashi, Koji Okuno, Yuki Matsushita, Takuma Nakatsuka, Kenichiro Enooku, Koji Sakaguchi, Yoshinao Kobayashi, Tetsuji Yamaguchi, Masatoshi Watanabe, Yoshiyuki Takei, Hayato Nakagawa
Publikováno v:
Hepatology Communications, Vol 6, Iss 8, Pp 1987-1999 (2022)
Abstract Caspase‐generated fragmented cytokeratin 18 (fCK18) is recognized as a useful noninvasive biomarker in the diagnosis of nonalcoholic fatty liver disease (NAFLD), particularly nonalcoholic steatohepatitis (NASH). However, fCK18 measurement
Externí odkaz:
https://doaj.org/article/f9f1c1e15e4f47858312cd5199aaa819
Autor:
Ryosuke Sugimoto, Motoh Iwasa, Akiko Eguchi, Yasuyuki Tamai, Ryuta Shigefuku, Naoto Fujiwara, Hideaki Tanaka, Yoshinao Kobayashi, Jiro Ikoma, Masahiko Kaito, Hayato Nakagawa
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Background/AimsPemafibrate is a selective peroxisome proliferator-activated receptor α modulator that improves serum alanine aminotransferase (ALT) in dyslipidemia patients. Pemafibrate was reported to reduce ALT in non-alcoholic fatty liver disease
Externí odkaz:
https://doaj.org/article/2465595da9d547e7aa5b66227262b005
Autor:
Taichi Abe, Masao Morishita, Ying Chen, Arkapol Saengdeejing, Kiyoshi Hashimoto, Yoshinao Kobayashi, Ikuo Ohnuma, Toshiyuki Koyama, Satoshi Hirosawa
Publikováno v:
Science and Technology of Advanced Materials, Vol 22, Iss 1, Pp 557-570 (2021)
For the Nd-Fe-B permanent magnets, a prototype thermodynamic database of the 8-element system (Nd, Fe, B, Al, Co, Cu, Dy, Ga) was constructed based on literature data and assessed parameters in the present work. The magnetic excess Gibbs energy of th
Externí odkaz:
https://doaj.org/article/7ba6171661474e25a506d77865c3cac3
Autor:
Yasuyuki Tamai, Akiko Eguchi, Ryuta Shigefuku, Hiroshi Kitamura, Mina Tempaku, Ryosuke Sugimoto, Yoshinao Kobayashi, Motoh Iwasa, Yoshiyuki Takei, Hayato Nakagawa
Publikováno v:
eLife, Vol 11 (2022)
Background: Hepatic sarcopenia is one of many complications associated with chronic liver disease (CLD) and has a high mortality rate; however, the liver-muscle axis is not fully understood. Therefore, few effective treatments exist for hepatic sarco
Externí odkaz:
https://doaj.org/article/9d9ad1ffcbca4c8bab44dc5bb9f59cc8
Autor:
Akiko Eguchi, Motoh Iwasa, Yasuyuki Tamai, Minori Yamada, Koji Okuno, Ryuta Shigefuku, Kyoko Yoshikawa, Mina Tempaku, Koji Sakaguchi, Hideaki Tanaka, Kazushi Sugimoto, Yoshinao Kobayashi, Tetsuji Yamaguchi, Hayato Nakagawa
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundFragmented cytokeratin 18 (fCK18) is released from damaged hepatocytes undergoing apoptosis and is recognized as a liver condition biomarker. We have developed a highly sensitive serum fCK18 CLEIA and reported that serum levels of this casp
Externí odkaz:
https://doaj.org/article/90440dda7ad3409da730080b9aa93306
Autor:
Yoshinao Kobayashi, Akiko Eguchi, Yasuyuki Tamai, Sanae Fukuda, Mina Tempaku, Kiyora Izuoka, Motoh Iwasa, Yoshiyuki Takei, Kenji Togashi
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Introduction/PurposeHigh-intensity interval training (HIIT) promotes various biological processes and metabolic effects in multiple organs, but the role of extracellular vesicles (EVs) released from a variety of cells is not fully understood during H
Externí odkaz:
https://doaj.org/article/419302c79db94d898840e6a1d0886d20
Autor:
Yasuyuki Tamai, Zhen Chen, Yue Wu, Jun Okabe, Yoshinao Kobayashi, Hitoshi Chiba, Shu-Ping Hui, Akiko Eguchi, Motoh Iwasa, Masaaki Ito, Yoshiyuki Takei
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 135, Iss , Pp 111181- (2021)
Branched-chain amino acids (BCAA) reverse malnutrition and l-carnitine leads to the reduction of hyperammonemia and muscle cramps in cirrhotic patients. BCAA and l-carnitine are involved in glucose and fatty acid metabolism, however their mechanistic
Externí odkaz:
https://doaj.org/article/9b392136ac4b4b79b1c98be10a9d503d
Autor:
Akiko Eguchi, Niklas Franz, Yoshinao Kobayashi, Motoh Iwasa, Nils Wagner, Frank Hildebrand, Yoshiyuki Takei, Ingo Marzi, Borna Relja
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Short Summary: Extracellular vesicles (EVs), released during tissue/cell injury, contain a “barcode” indicating specific microRNAs (miRs) that can uncover their origin. We examined whether systemic EVs possessing hepatic miR-signatures would indi
Externí odkaz:
https://doaj.org/article/40bad335a99e428291a503a3f94fac64
Autor:
Motoh Iwasa, Yoshinao Kobayashi, Rumi Mifuji-Moroka, Nagisa Hara, Hirohide Miyachi, Ryosuke Sugimoto, Hideaki Tanaka, Naoki Fujita, Esteban C Gabazza, Yoshiyuki Takei
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70309 (2013)
Long-term supplementation with branched-chain amino acids (BCAA) is associated with prolonged survival and decreased frequency of development of hepatocellular carcinoma (HCC) in patients with liver cirrhosis. However, the pharmaceutical mechanism un
Externí odkaz:
https://doaj.org/article/38667755c6ea4de18d47aec8a59045f0