Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yoshinao Kato"'
Publikováno v:
Bioengineering, Vol 11, Iss 4, p 302 (2024)
In a previous study, a novel human corneal-like epithelium model utilizing an immortalized human corneal epithelial cell line (iHCE-NY1) was developed as an alternative to animal models to identify chemicals not classified under the United Nations Gl
Externí odkaz:
https://doaj.org/article/e5a972caf294425aa16aeed733e17d1b
Autor:
Masayuki Saimura, Munenori Takehara, Kazuya Yamanaka, Tatsuki Matsunaga, Yoshinao Kato, Haruka Inaba, Shogo Muro
Publikováno v:
Applied Microbiology and Biotechnology. 105:3145-3157
Polymers of basic amino acids function as polycationic compounds under physiological conditions and exhibit intriguing biological properties, such as antimicrobial and antiviral activities, immunopotentiating ability, and DNA-binding activity. Poly(e
Publikováno v:
Applied In Vitro Toxicology. 6:99-106
Introduction: In the last decade, a variety of in vitro eye irritation test (EIT) methods have been developed and validated as an alternative to animal testing to assess the ocular toxicity of chem...
Autor:
Hajime Kojima, Yoshinao Kato, Masayuki Horiguchi, Atsushi Sato, Naoki Yamamoto, Ei-ichi Miyachi, Koji Hirano, Hiromi Yamashita, Noriko Hiramatsu, Mahito Ohkuma
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 52:742-748
In vitro test methods that use human corneal epithelial cells to evaluate the eye irritation potency of chemical substances do not use human corneal epithelium because it has been difficult to maintain more than four passages. In this study, we make
Autor:
Kenji Okamoto, Shinichi Watanabe, Shiho Fukui, Daisuke Sekiya, Takao Ashikaga, Toshihiko Kasahara, Noriyasu Imai, Masaharu Fujita, Masaaki Miyazawa, Hirokazu Seto, Miyuki Fujishiro, Yoshinao Kato, Akemi Toyoda, Osamu Takenouchi, Satoru Kurotani, Morihiko Hirota, Daiki Kyotani
Publikováno v:
Journal of Applied Toxicology. 35:1333-1347
The skin sensitization potential of chemicals has been determined with the use of the murine local lymph node assay (LLNA). However, in recent years public concern about animal welfare has led to a requirement for non-animal risk assessment systems f
Autor:
Shinichi Watanabe, Satoru Kurotani, Hirokazu Seto, Miyuki Fujishiro, Yoshinao Kato, Noriyasu Imai, Toshihiko Kasahara, Masaaki Miyazawa, Masaharu Fujita, Kenji Okamoto, Daisuke Sekiya, Shiho Fukui, Daiki Kyotani, Morihiko Hirota, Takao Ashikaga, Akemi Toyoda, Osamu Takenouchi
Publikováno v:
Journal of Applied Toxicology. 35:1318-1332
To develop a testing strategy incorporating the human cell line activation test (h-CLAT), direct peptide reactivity assay (DPRA) and DEREK, we created an expanded data set of 139 chemicals (102 sensitizers and 37 non-sensitizers) by combining the exi
Publikováno v:
Applied In Vitro Toxicology; Sep2020, Vol. 6 Issue 3, p99-106, 8p
Autor:
Toshiyuki Saito, Taisuke Inagaki, Hiroko Tonai-Kachi, Yoshinao Kato, Shinichi Sakemi, Nakao Kojima, Toshio Ichiba, Hiroyuki Nishida, Hideo Hirai, Janice C. Parker, Yasuhiro Kojima, Maria A. Vanvolkenburg, Nobuji Yoshikawa
Publikováno v:
The Journal of Antibiotics. 55:941-951
High-throughput screening of microbial extracts using rat hepatic microsomal glucose-6-phosphatase (G6Pase) led us to find thielavin B as a G6Pase inhibitor with inhibition of glucose output from glucagon-stimulated hepatocytes. Further searching for
Autor:
Morihiko, Hirota, Shiho, Fukui, Kenji, Okamoto, Satoru, Kurotani, Noriyasu, Imai, Miyuki, Fujishiro, Daiki, Kyotani, Yoshinao, Kato, Toshihiko, Kasahara, Masaharu, Fujita, Akemi, Toyoda, Daisuke, Sekiya, Shinichi, Watanabe, Hirokazu, Seto, Osamu, Takenouchi, Takao, Ashikaga, Masaaki, Miyazawa
Publikováno v:
Journal of applied toxicology : JAT. 35(11)
The skin sensitization potential of chemicals has been determined with the use of the murine local lymph node assay (LLNA). However, in recent years public concern about animal welfare has led to a requirement for non-animal risk assessment systems f
Autor:
Osamu, Takenouchi, Shiho, Fukui, Kenji, Okamoto, Satoru, Kurotani, Noriyasu, Imai, Miyuki, Fujishiro, Daiki, Kyotani, Yoshinao, Kato, Toshihiko, Kasahara, Masaharu, Fujita, Akemi, Toyoda, Daisuke, Sekiya, Shinichi, Watanabe, Hirokazu, Seto, Morihiko, Hirota, Takao, Ashikaga, Masaaki, Miyazawa
Publikováno v:
Journal of applied toxicology : JAT. 35(11)
To develop a testing strategy incorporating the human cell line activation test (h-CLAT), direct peptide reactivity assay (DPRA) and DEREK, we created an expanded data set of 139 chemicals (102 sensitizers and 37 non-sensitizers) by combining the exi