Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yoshimichi Imamura"'
Autor:
Koichi Inusima, Kazuhiko Shimizu, Toru Miyajima, Kazuo Takazawa, Yoshimichi Imamura, Masahiro Tsuda, Mami Kayano, Takeshi Ogura, Kazuhisa Kitazaki, Takahiko Nakamura
Publikováno v:
Nihon Naika Gakkai Zasshi. 91:728-730
症例は79歳,男性.左半身不全麻痺と全身の紫斑を主訴に当科受診.頭部CT検査にて左頭頂葉に血腫を認め,血小板数が0.2×104/μlと減少していた.特発性血小板減少性紫斑病(ITP)と診断し,ステロ
Autor:
Yukio Yoshimura, Mitsuru Tokisue, Manabu Oya, Terumasa Sashikata, Koichi Yasutake, Yoshimichi Imamura, Kenji Matsushita
Publikováno v:
Gastroenterologia Japonica. 25(2)
In precancerous states or early cancer, the serum levels of tumor markers are almost not detectable. Therefore, the tissue contents of CEA and CA19-9 were measured in 48 colonic polyps, 8 colorectal cancers and 5 normal colonie mucosa. These tissue s
Publikováno v:
Endocrinologia Japonica. 29:299-306
Kinetic studies on 125I-insulin binding and degradation were examined using liver plasma membrane and cytosol fractions from fed and fasted rats.Liver plasma membranes of 72h fasted rats bound twice as much insulin as did membranes of fed rats. Scatc
Autor:
Yoshikazu Hirose, Shigeaki Baba, Hiroshi Taniguchi, Keiji Murakami, Kazushige Ejiri, Yoshimichi Imamura, K. Ishihara, Katsuhiro Terashi
Publikováno v:
Diabetes Research and Clinical Practice. 1:73-79
Tris(hydroxymethyl)aminomethane (Tris) has been shown to inhibit selectively the Golgi apparatus and Golgi-endoplasmic reticulum-lysosomal system (GERL system) of several kinds of cells including pancreatic B cells. This study was designed to assess
Publikováno v:
Diabetes. 29:856-859
Insulin-degrading enzyme (IDE), which proteolytically degraded insulin with a high degree of specificity, was purified from pig skeletal muscle by ammonium sulfate precipitation, chromatography on Bio-Gel P-200 and DEAE-cellulose, and finally rechrom
Autor:
Yoshimichi Imamura, Shu-fan Zeng, Shigeaki Baba, Kazuhiko Amano, Koichi Yokono, Shinji Yaso, Kozui Shii, Joji Hari
Publikováno v:
Folia Endocrinologica Japonica. 61:642-652
We have studied the internalization of insulin and the mechanism of insulin degradation in cultured Bri-7K human lymphocytes. The internalization of 125I-insulin was observed by using an acid extraction technique by Heigler's method which removed sur
Publikováno v:
Diabetes. 28:810-817
We isolated the plasma membrane from rat skeletal muscle without using drastic procedures such as extraction by salts or other agents. As a result of the purity of our preparations, evaluated by enzymatic markers, lipid composition, 125l-insulin spec
Publikováno v:
Folia Endocrinologica Japonica. 60:30-43
Insulin degradation by isolated rat hepatocytes was investigated. Using the preincubation method, the extracellular insulin-degrading activity was removed from the medium over 120 min at 15 degrees C and 60 min at 37 degrees C. The degradation of ins
Autor:
Shigeaki Baba, Shinji Yaso, Kazuyoshi Yonezawa, Kazuhiko Amano, Taizo Sakamoto, Yoshimichi Imamura, Koichi Yokono, Joji Hari, Kozui Shii, Yoshito Kawase
Publikováno v:
Endocrinology. 118(5)
We have previously reported on the purification, characterization, and biological significance of insulin-degrading enzyme (IDE) from pig and rat skeletal muscle. In the present study, we have investigated the detection and the HPLC separation of deg
Publikováno v:
Japanese journal of medicine. 23(1)
Proinsulin, insulin and C-peptide levels were investigated in chronic renal, hepatic and muscular disorders. The proinsulin levels in human plasma were determined by radioimmunoassay using insulin-degrading enzyme (IDE). The fasting levels of proinsu