Zobrazeno 1 - 10
of 787
pro vyhledávání: '"Yoshimi Takai"'
Autor:
Rumi Kawashima, Kenji Matsushita, Kenji Mandai, Yuko Sugita, Tomohiko Maruo, Kiyohito Mizutani, Yoshihiro Midoh, Akiko Oguchi, Yasuhiro Murakawa, Kazuki Kuniyoshi, Ryohei Sato, Takahisa Furukawa, Kohji Nishida, Yoshimi Takai
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109577- (2024)
Summary: In vertebrates, retinal neural circuitry for visual perception is organized in specific layers. The outer plexiform layer is the first synaptic region in the visual pathway, where photoreceptor synaptic terminals connect with bipolar and hor
Externí odkaz:
https://doaj.org/article/2d2e6e92c3ed415b836cfa08d982c830
Autor:
Takeshi Kameyama, Muneaki Miyata, Hajime Shiotani, Jun Adachi, Soichiro Kakuta, Yasuo Uchiyama, Kiyohito Mizutani, Yoshimi Takai
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108010- (2023)
Summary: Astrocytes interact with not only synapses but also brain blood vessels through perivascular astrocyte endfeet (PV-AEF) to form the neurovascular unit (NVU). However, PV-AEF components have not been fully identified. Here, we biochemically i
Externí odkaz:
https://doaj.org/article/284f87b094cb43ccba6d8301bf19a4f1
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Nectin-4, upregulated in various cancer cells, cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, p95-ErbB2 and ErbB2∆Ex16, enhancing DNA synthesis through the PI3K-AKT signaling in human breast cancer T47D cells in an
Externí odkaz:
https://doaj.org/article/99f8aaea17514bb6bbbfd0ca3ec93547
Autor:
Ayumu Sugiura, Tatsuhiro Shimizu, Takeshi Kameyama, Tomohiko Maruo, Shin Kedashiro, Muneaki Miyata, Kiyohito Mizutani, Yoshimi Takai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
The hypothalamus plays a central role in homeostasis and aging. The hypothalamic arcuate nucleus (ARC) controls homeostasis of food intake and energy expenditure and retains adult neural stem cells (NSCs)/progenitor cells. Aging induces the loss of N
Externí odkaz:
https://doaj.org/article/19ced8581e4148119b9d58eebb79c14b
Autor:
Erica Russo, Peter Runge, Neda Haghayegh Jahromi, Heidi Naboth, Angela Landtwing, Riccardo Montecchi, Noémie Leicht, Morgan Campbell Hunter, Yoshimi Takai, Cornelia Halin
Publikováno v:
Cells, Vol 10, Iss 1, p 169 (2021)
Junctional adhesion proteins play important roles in controlling angiogenesis, vascular permeability and leukocyte trafficking. CD112 (nectin-2) belongs to the immunoglobulin superfamily and was shown to engage in homophilic and heterophilic interact
Externí odkaz:
https://doaj.org/article/48c9bb8f0a614e5d888c34399f17462b
Autor:
Rajeshree Pujari, Richard Hunte, Remy Thomas, Louise van der Weyden, Dan Rauch, Lee Ratner, Jennifer K Nyborg, Juan Carlos Ramos, Yoshimi Takai, Noula Shembade
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004721 (2015)
Persistent activation of NF-κB by the Human T-cell leukemia virus type 1 (HTLV-1) oncoprotein, Tax, is vital for the development and pathogenesis of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Externí odkaz:
https://doaj.org/article/59795e6ce34646e6add2be32726c3600
Autor:
Kentaro Nobutani, Yohei Shimono, Kiyohito Mizutani, Yuki Ueda, Toshihiro Suzuki, Midori Kitayama, Akihiro Minami, Kenji Momose, Kohta Miyawaki, Koichi Akashi, Takeshi Azuma, Yoshimi Takai
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130032 (2015)
Our understanding of the mechanism of cancer dormancy is emerging, but the underlying mechanisms are not fully understood. Here we analyzed mouse xenograft tumors derived from human breast cancer tissue and the human breast cancer cell line MDA-MB-23
Externí odkaz:
https://doaj.org/article/24609539c18441ce81335241bf8dc3d2
Autor:
Shota Yamana, Amina Tokiyama, Kiyohito Mizutani, Ken-ichi Hirata, Yoshimi Takai, Yoshiyuki Rikitake
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124259 (2015)
Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for this contact inhibition using cultured vascular endothelial cells. When the cells were con
Externí odkaz:
https://doaj.org/article/2f7ec5b8b48745ea9cc666ceb859dcf2
Autor:
Miki Tanaka-Okamoto, Yu Itoh, Jun Miyoshi, Akira Mizoguchi, Kiyohito Mizutani, Yoshimi Takai, Masahiro Inoue
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110549 (2014)
Afadin is an actin filament-binding protein that acts cooperatively in cell adhesion with the cell adhesion molecule nectin, and in directional cell movement with the small G protein Rap1 in a nectin-independent manner. We studied the role of afadin
Externí odkaz:
https://doaj.org/article/7c61f311614d47bfb5da3f4cd2eb76e6
Autor:
Daisaku Toyoshima, Kenji Mandai, Tomohiko Maruo, Irwan Supriyanto, Hideru Togashi, Takahito Inoue, Masahiro Mori, Yoshimi Takai
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89763 (2014)
The formation and remodeling of mossy fiber-CA3 pyramidal cell synapses in the stratum lucidum of the hippocampus are implicated in the cellular basis of learning and memory. Afadin and its binding cell adhesion molecules, nectin-1 and nectin-3, toge
Externí odkaz:
https://doaj.org/article/3d5db2a9240b42999de4577783731600