Výsledky vyhledávání - "Yoshimi E. Greer"

Akademický článek

Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer

Autor: Emily M. J. Fennell, Lucas J. Aponte-Collazo, Wimal Pathmasiri, Blake R. Rushing, Natalie K. Barker, Megan C. Partridge, Yuan-Yuan Li, Cody A. White, Yoshimi E. Greer, Laura E. Herring, Stanley Lipkowitz, Susan C. J. Sumner, Edwin J. Iwanowicz, Lee M. Graves

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been

Externí odkaz: https://doaj.org/article/8ff4ea8f38e048409bf256e5266ae0c6

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Mitochondrial Matrix Protease ClpP Agonists inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

Autor: Yoshimi E. Greer, Lidia Hernandez, Emily M. J. Fennell, Donna Voeller, Raj Chari, Sam Gilbert, Binwu Tang, Markus Hafner, Christina M. Annunziata, Edwin Iwanowicz, Lee M. Graves, Stanley Lipkowitz

Mitochondria are multifaceted organelles which are important for bioenergetics, biosynthesis and signaling in metazoans. Mitochondrial functions are frequently altered in cancer to promote both the energy and the necessary metabolic intermediates for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4b5b888042c04f08ec55d3c0243f4c9
https://doi.org/10.1101/2022.03.18.484947

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Abstract P127: Mitochondrial matrix protease ClpP agonists suppress breast cancer stem cell function by downregulating multiple stem cell regulatory mechanisms

Autor: Yoshimi E. Greer, Lidia Hernandez, Donna Voeller, Raj Chari, Binwu Tang, Christina M. Annunziata, Sam Gilbert, Lalage Wakefield, Edwin Iwanowicz, Lee M. Graves, Stanley Lipkowitz

Publikováno v: Molecular Cancer Therapeutics. 20:P127-P127

Background: We previously reported that small molecule ONC201 induces mitochondrial structural and functional damage, leading to death in breast cancer cells. Subsequent studies demonstrated that ONC201 and the related analogs TR compounds are agonis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fe58277bf8193c216e63414fd5603f1
https://doi.org/10.1158/1535-7163.targ-21-p127

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