Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Yoshimasa Uehara"'
Autor:
Yusuke Oku, Naoyuki Nishiya, Toshiya Shito, Reiichiro Yamamoto, Yasufumi Yamamoto, Chihiro Oyama, Yoshimasa Uehara
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 542-549 (2015)
YAP and TAZ oncoproteins confer malignancy and drug resistance to various cancer types. We screened for small molecules that inhibit the nuclear localization of YAP/TAZ. Dasatinib, statins and pazopanib inhibited the nuclear localization and target g
Externí odkaz:
https://doaj.org/article/2f27729b2ead4ba6a3e64c9ad0f4f4a0
Autor:
Yusuke Oku, Chiaki Tareyanagi, Shinichi Takaya, Sayaka Osaka, Haruki Ujiie, Kentaro Yoshida, Naoyuki Nishiya, Yoshimasa Uehara
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92402 (2014)
Accurate chromosome segregation is vital for cell viability. Many cancer cells show chromosome instability (CIN) due to aberrant expression of the genes involved in chromosome segregation. The induction of massive chromosome segregation errors in suc
Externí odkaz:
https://doaj.org/article/93b9e620031a4a839670dc3222e9bfb7
Autor:
Masaaki Matsuura, Honami Yonezawa, Naoyuki Nishiya, Tomoko Sakyo, Shingo Dan, Tsutomu Fukuda, Masatomo Iwao, Yusuke Oku, Fumito Ishibashi, Yoko Furukawa, Yuka Sasaki, Takao Yamori, Masaru Ushijima, Yoshimasa Uehara, Tetsuo Mashima, Hiroyuki Seimiya, Akihiro Tomida, Chie Ishikawa, Keishi Otsu, Masanori Abe
Publikováno v:
Cancer Science
The emergence of acquired resistance is a major concern associated with molecularly targeted kinase inhibitors. The C797S mutation in the epidermal growth factor receptor (EGFR) confers resistance to osimertinib, a third‐generation EGFR‐tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c37c62d785bb3926e6f2c019635be7
http://europepmc.org/articles/PMC8088975
http://europepmc.org/articles/PMC8088975
Autor:
Honami Yonezawa, Akari Ikeda, Ryo Takahashi, Haruka Endo, Yasuyo Sugawara, Mikako Goto, Mirute Kanno, Sosuke Ogawa, Karin Nakamura, Haruki Ujiie, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Yoshimasa Uehara, Naoyuki Nishiya
Publikováno v:
iScience. 25(3)
Ivermectin (IVM), an avermectin-derivative anthelmintic, specifically binds to glutamate-gated chloride ion channels (GluCls), causing paralysis in invertebrates. IVM also exhibits other biological activities such as Wnt/β-catenin pathway inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ace8cde589d33a962ca57b77ff5b65
https://pubmed.ncbi.nlm.nih.gov/35530256
https://pubmed.ncbi.nlm.nih.gov/35530256
Autor:
Tomoko Sakyo, Yoshimasa Uehara, Tomikazu Kawano, Aoi Sugawara, Honami Yonezawa, Naoyuki Nishiya
Publikováno v:
Biochemical and biophysical research communications. 532(3)
Aberrant activation of the canonical Wnt/β-catenin signaling pathway triggers tumorigenesis in various tissues. This study identified an atrarate compound, IMU14, derived from filamentous fungi as an inhibitor of Wnt/β-catenin signaling in phenotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77447b63359371e29c7bc362e269c28c
https://pubmed.ncbi.nlm.nih.gov/32891433
https://pubmed.ncbi.nlm.nih.gov/32891433
Autor:
Yusuke Oku, Naoyuki Nishiya, Sota Katayama, Yoshimasa Uehara, Tomoko Sakyo, Mami Ogawa, Norikazu Omori, Honami Yonezawa, Yui Shimizu
Publikováno v:
Biochemical and Biophysical Research Communications. 506:183-188
The Wnt/β-catenin signaling pathway controls cell proliferation and differentiation, and therefore, when this pathway is excessively activated, it causes tumorigenesis. Our chemical suppressor screening in zebrafish embryos identified antifungal azo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c554e1c34ca40df55be298b6d831d1e
https://doi.org/10.1016/j.bbrc.2018.10.053
https://doi.org/10.1016/j.bbrc.2018.10.053
Autor:
Takaaki Tazawa, Naoyuki Nishiya, Yusuke Oku, Yasuyo Sugawara, Nanami Umezawa, Yoshimasa Uehara, Takaya Kobayashi
Publikováno v:
FEBS Open Bio. 8:1001-1012
The main reasons for failure of cancer chemotherapy are intrinsic and acquired drug resistance. The Hippo pathway effector Yes-associated protein (YAP) is associated with resistance to both cytotoxic and molecular targeted drugs. Several lines of evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdf87201a7da6e194c909a3fa14a6e47
https://doi.org/10.1002/2211-5463.12440
https://doi.org/10.1002/2211-5463.12440
Dynamic Phenotypic Transition of Breast Cancer Cells In Vitro Revealed by Self-floating Cell Culture
Autor:
Yoshimasa Uehara, Chihaya Maesawa, Yusuke Oku, Naoyuki Nishiya, Kayoko Tsuda, Masahiko Shibazaki
Publikováno v:
Anticancer Research. 37:1793-1797
Background Breast tumor heterogeneity leads to phenotypic diversity, such as tumor-initiating and metastatic properties and drug sensitivity. Materials and methods We found that a self-floating cell (SFC) culture enriches a drug-resistant subpopulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb990dfd0bdb777049a389daa7b7df5
https://doi.org/10.21873/anticanres.11513
https://doi.org/10.21873/anticanres.11513
Autor:
Yoshimasa Uehara, Masatomo Iwao, Tsutomu Fukuda, Yusuke Oku, Kentaro Yamashita, Akane Nakahara, Naoyuki Nishiya, Fumito Ishibashi, Kazuaki Matsukura, Mizuho Anzai
Publikováno v:
Bioorganic & Medicinal Chemistry. 34:116039
Azalamellarin N, a synthetic lactam congener of the marine natural product lamellarin N, and its A-ring-modified analogues were synthesized and evaluated as potent and non-covalent inhibitors of the drug-resistant epidermal growth factor receptor T79
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbac58ec5b4467145030f068ad4ffe5
https://doi.org/10.1016/j.bmc.2021.116039
https://doi.org/10.1016/j.bmc.2021.116039
Publikováno v:
Anticancer research. 38(6)
Background Transcriptional co-activators YES-associated protein (YAP) and transcriptional coactivator with PDZ-motif (TAZ) stimulate the expression of cell cycle-related genes to permit for tumour cell growth. MLN8237 is a potent aurora-A kinase inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd1b3884c529fb3e9bc0dae0b35f0f6
https://pubmed.ncbi.nlm.nih.gov/29848699
https://pubmed.ncbi.nlm.nih.gov/29848699