Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yoshimasa Isakari"'
Autor:
Yoshihisa Yamada, Hiroyuki Fujiki, Hiroshi Mizuguchi, Yukinobu Takeshita, Katsuji Hattori, Koji Ohmoto, Miki Aihara, Keisuke Nagano, Yoshimasa Isakari, Miho Yamamoto, Yoshitaka Yamamura
Publikováno v:
Folia Pharmacologica Japonica. 157:254-260
Autor:
Yoshihisa, Yamada, Hiroyuki, Fujiki, Hiroshi, Mizuguchi, Yukinobu, Takeshita, Katsuji, Hattori, Koji, Ohmoto, Miki, Aihara, Keisuke, Nagano, Yoshimasa, Isakari, Miho, Yamamoto, Yoshitaka, Yamamura
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 157(4)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. Fluid-filled cysts develop and enlarge in both kidneys, eventually leading to kidney failure. Tolvaptan is a selective vasopressin V
Autor:
Takao Taki, Takuma Kawakami, Yoshimasa Isakari, Hiroshi Kiwada, Shinji Sogo, Toshihide Ono, Tatsuhiro Ishida
Publikováno v:
Biologicalpharmaceutical bulletin. 32(3)
A comprehensive gene-expression analysis during platelet (PLT) production from megakaryocytes may give important information on genes involved in the PLT production process. However, the low abundance of primary megakaryocytes makes the gene expressi
Autor:
Keiichi Kawano, Yoshihiro Terada, Taiji Imoto, Hidenori Yamada, Tadashi Ueda, Shun ichi Masutomo, Yoshimasa Isakari, Takanori Yasukochi, Hidenori Aoki
Publikováno v:
The Journal of Biochemistry. 109:690-698
We prepared the lysozyme derivative in which the beta-carboxyl group of Asp101 was modified with alpha-O-methyl N-glycylglucosaminide as an amide by means of the carbodimide reaction (alpha-MGG lysozyme). Since Asp101 residue is located at the edge o
Autor:
Toshiki Sudo, Takao Taki, Yoshimasa Isakari, Hiroshi Kiwada, Shinji Sogo, Tatsuhiro Ishida, Kuniko Matsumura-Takeda
Publikováno v:
Biologicalpharmaceutical bulletin. 31(4)
The mechanism of megakaryopoiesis, proplatelet formation (PPF) and platelet (PLT) production is not fully elucidated. Lactoferrin (LF) has been reported to have many biological functions including cell proliferation and differentiation, and the LF re
Autor:
Kuniko Matsumura-Takeda, Kinue Nishioka, Takuma Kawakami, Yoshimasa Isakari, Takao Taki, Yasuo Harada, Toshihide Ono, Shinji Sogo
Publikováno v:
Stem cells (Dayton, Ohio). 25(4)
Murine megakaryocytes (MKs) are defined by CD41/CD61 expression and acetylcholinesterase (AChE) activity; however, their stages of differentiation in bone marrow (BM) have not been fully elucidated. In murine lineage-negative (Lin−)/CD45+ BM cells,
Autor:
Yasuo Harada, Yoshimasa Isakari, Dai Ishikawa, Hiroshi Kiwada, Shinji Sogo, Kuniko Matsumura-Takeda, Takao Taki, Tatsuhiro Ishida
Publikováno v:
International journal of pharmaceutics. 338(1-2)
To clarify the mechanism of platelet production from megakaryocytes, expression of target proteins by gene transfection was examined using various gene delivery techniques. Transfection into hematopoietic cells, including megakaryocytes, by conventio
Autor:
Taiji Imoto, Tadashi Ueda, Yoshimasa Isakari, Hidenori Yamada, Takeyoshi Miki, Tomohiro Tamura, Yoshito Abe, Makoto Inoue, Keiichi Kawano
Publikováno v:
Protein engineering. 7(6)
Mutations around His15 which lie far away from the active site, stimulated glycol chitin activity of lysozyme at physiological temperature. Del-Arg14His15 lysozyme, a mutant lysozyme whose Arg14 and His15 were deleted together, and has the highest ac
Autor:
Kuniko Matsumura-Takeda, Shinji Sogo, Yasuo Harada, Yoshimasa Isakari, Kinue Nishioka, Takao Taki, Takuma Kawakami, Toshihide Ono
Publikováno v:
Blood. 106:2265-2265
Platelets (PLT) are produced from megakaryocytes (Mks) via proplatelet formation (PPF). However, the molecular mechanisms from Mks to PPF are not clearly elucidated, because the maturational steps of the Mks in bone marrow (BM) are not analyzed in de