Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Yoshikuni Yakabe"'
Autor:
Hiroshi Matsumoto, Yoshikuni Yakabe, Fumiyo Saito, Koichi Saito, Kayo Sumida, Masaru Sekijima, Koji Nakayama, Hideki Miyaura, Masanori Otsuka, Tomoyuki Shirai
Publikováno v:
Cancer Informatics, Vol 2011, Iss 10, Pp 259-271 (2011)
Externí odkaz:
https://doaj.org/article/53ba1cbdf2d045b78670332f40c1d031
Autor:
Hiroshi Matsumoto, Yoshikuni Yakabe, Koichi Saito, Kayo Sumida, Masaru Sekijima, Koji Nakayama, Hideki Miyaura, Fumiyo Saito, Masanori Otsuka, Tomoyuki Shirai
Publikováno v:
Cancer Informatics, Vol 2009, Iss 7, Pp 253-269 (2009)
This study aimed at discriminating carcinogens on the basis of hepatic transcript profiling in the rats administrated with a variety of carcinogens and non-carcinogens. We conducted 28-day toxicity tests in male F344 rats with 47 carcinogens and 26 n
Externí odkaz:
https://doaj.org/article/7b8ed76dfca84707b3588d7eba90cad2
Autor:
Hirofumi Yokota, Haruko Takeyama, Yoshihisa Sudo, Tadashi Matsunaga, Fumiyo Saito, Yoshikuni Yakabe
Publikováno v:
Toxicology in Vitro. 22:1077-1087
Mammalian cell models for gene knock-out/knock-in experiments are important for functional analysis of genes and have a potential of useful tool for toxicological studies. However, uncontrolled insertion of transgenes has raised significant concerns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bf18340df0b2df597f42b165fcf44c
https://doi.org/10.1016/j.tiv.2008.01.019
https://doi.org/10.1016/j.tiv.2008.01.019
Autor:
Hidenori Yamanaka, Masahiro Takeyoshi, Hisaya Sato, Mineo Takatsuki, Yoshikuni Yakabe, Yasushi Minobe
Publikováno v:
Drug Metabolism Letters. 1:281-286
Cytochrome P450 isoforms from male rat liver microsomes were comprehensively identified using nano liquid chromatography tandem mass spectrometry (nanoLC-MS/MS). The enrichment of P450, an endomembrane-anchored heme protein, was achieved by solubilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99925a279d3694236f10de35d4d40a2e
https://doi.org/10.2174/187231207783221394
https://doi.org/10.2174/187231207783221394
Autor:
Daisuke Asai, Yasuyuki Shimohigashi, Makoto Nakai, Kaoru Kondo, Teruo Shinmyozu, Tsutomu Kawaguchi, Takatoshi Tokunaga, Yoshikuni Yakabe, Sayaka Takayanagi
Publikováno v:
Journal of Biochemistry. 143:781-792
Steroidal nuclear receptors (NRs) have been acknowledged as a target binding protein of so-called endocrine disruptors. It is therefore necessary to develop an efficient assay system for screening these endocrine-disrupting chemicals. We here describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaa1c6de1ea5a9c60251d8cb017aa37
https://doi.org/10.1093/jb/mvn031
https://doi.org/10.1093/jb/mvn031
Autor:
Koji Nakayama, Hiroshi Matsumoto, Masaru Sekijima, Kenji Oeda, Koichi Saito, Yoshikuni Yakabe, Kayo Sumida, Tomoyuki Shirai, Yukiko Kawano, Masanori Otsuka
Publikováno v:
The Journal of Toxicological Sciences. 32:261-288
Alpha-hexachlorocyclohexane (alpha-HCH) is a stereoisomer of gamma-HCH, the active ingredient of lindane (> 99% gamma-HCH). In the present study, cDNA microarray technology was employed to identify changes in gene expression associated with toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8fe907d2c57033d022705d1f254249
https://doi.org/10.2131/jts.32.261
https://doi.org/10.2131/jts.32.261
Autor:
Tomoko Yoshino, Yoshikuni Yakabe, Makoto Nakai, Fukuichi Kato, Tadashi Matsunaga, Haruko Takeyama
Publikováno v:
Analytica Chimica Acta. 532:105-111
In this study, nano-sized bacterial magnetic particles (BMPs) displaying human estrogen receptor ligand binding domain (ERLBD) on the surface was successfully produced by the magnetic bacterium, Magnetospirillum magneticum AMB-1. Furthermore, a non-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f476bd16815ac2d85aa06f4bdaab29ff
https://doi.org/10.1016/j.aca.2004.10.074
https://doi.org/10.1016/j.aca.2004.10.074
Autor:
Yoshikuni Yakabe, Makoto Nakai, Takako Muroi, Masakuni Sawaki, Satoko Sakamoto, Kanji Yamasaki, Hideo Mitoma, Shoji Noda, Saori Takakura
Publikováno v:
Toxicology. 195:177-186
We performed the Hershberger assay of 12 chemicals based on the OECD draft protocol. The chemicals tested by the Hershberger assay were phthalic acid di-n-hexyl ester, phthalic acid di-n-amyl ester, phthalic acid di-n-propyl ester, diethylstilbestrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959c0e5dd457f36891fed8b0e6353744
https://doi.org/10.1016/j.tox.2003.09.012
https://doi.org/10.1016/j.tox.2003.09.012
Publikováno v:
Toxicology Letters. 146:111-120
We performed an immature rat uterotrophic assay of 14 chemicals having various receptor-binding affinities in order to assess the relationship between their uterotrophic potency and receptor-binding affinity. The chemicals tested were phthalic acid d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350f5a8cf21c530a3eb3b60a6949ece6
https://doi.org/10.1016/j.toxlet.2003.07.003
https://doi.org/10.1016/j.toxlet.2003.07.003
Autor:
Masanori Ikeda, Yoshihisa Sudo, Hiroshi Tadokoro, Naoaki Yakata, Hiroyuki Fukui, Yoshikuni Yakabe, Kenichi Sanechika
Publikováno v:
Chemosphere. 51:153-161
The bioconcentration factors (BCFs) of seven new aryl fluoroalkyl ethers––four bis-4-tetrafluoroethoxyphenyl-type (bis-type) compounds and three mono-4-tetrafluoroethoxyphenyl-type (mono-type) compounds––were obtained by bioconcentration test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c43917e776c2f777feb71e679c3f26
https://doi.org/10.1016/s0045-6535(02)00706-3
https://doi.org/10.1016/s0045-6535(02)00706-3