Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Yoshiko TAKAGISHI"'
Autor:
Yuko Takano, Kenji Kasai, Yoshiko Takagishi, Toyone Kikumori, Tsuneo Imai, Yoshiharu Murata, Yoshitaka Hayashi
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133812 (2015)
Animal models with defective glucagon action show hyperplasia of islet α-cells, however, the regulatory mechanisms underlying the proliferation of islet endocrine cells remain largely to be elucidated. The Gcggfp/gfp mice, which are homozygous for g
Externí odkaz:
https://doaj.org/article/b6d8e50aef1e46718f754d152582fb8e
Autor:
Keiko Miwa, Jong-Kook Lee, Yoshiko Takagishi, Tobias Opthof, Xianming Fu, Masumi Hirabayashi, Kazuhiko Watabe, Yasuhiko Jimbo, Itsuo Kodama, Issei Komuro
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e65202 (2013)
Molecular signaling of cardiac autonomic innervation is an unresolved issue. Here, we show that glial cell line-derived neurotrophic factor (GDNF) promotes cardiac sympathetic innervation in vitro and in vivo. In vitro, ventricular myocytes (VMs) and
Externí odkaz:
https://doaj.org/article/9e1e10d72205481caed266be9edb0950
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64415 (2013)
Defects in glucagon action can cause hyperplasia of islet α-cells, however, the underlying mechanisms remain largely to be elucidated. Mice homozygous for a glucagon-GFP knock-in allele (Gcg(gfp/gfp) ) completely lack proglucagon-derived peptides an
Externí odkaz:
https://doaj.org/article/584093339d5f4b56b3f2c6a4ec246b89
Autor:
Xiao-yang Sun, Yoshitaka Hayashi, Sai Xu, Yasuhiko Kanou, Yoshiko Takagishi, Ya-ping Tang, Yoshiharu Murata
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14605 (2011)
Obesity is a serious international health problem that increases the risk of several diet-related chronic diseases. The genetic factors predisposing to obesity are little understood. Rcan2 was originally identified as a thyroid hormone-responsive gen
Externí odkaz:
https://doaj.org/article/aadd9937ce6f471f95b31d0d54f485b7
Publikováno v:
Neurobiology of Aging. 43:34-46
Emerging evidence suggests that axonal degeneration is a disease mechanism in various neurodegenerative diseases and that the paranodes at the nodes of Ranvier may be the initial site of pathogenesis. We investigated the pathophysiology of the diseas
Autor:
Daniel J. Drucker, Yoshiko Takagishi, Michiyo Yamamoto, Eriko Sakamoto-Miura, Shin Tsunekawa, Ayako Fukami, Yusuke Seino, Yutaka Seino, Yoshiharu Murata, Chisato Sugiyama, Yoshitaka Hayashi, Nobuaki Ozaki, Safina Ali, Tatsuhito Himeno, Yutaka Oiso
Publikováno v:
Diabetes
Glucagon and glucagon-like peptide-1 (GLP-1) are produced in pancreatic a-cells and enteroendocrine L-cells, respectively, in a tissue-specific manner from the same precursor, proglucagon, that is encoded by glucagon gene (Gcg), and play critical rol
Autor:
Katsumi Shibata, Jun Sato, Yoshitaka Hayashi, Hiroki Miyahira, Yutaka Oiso, Yoshiko Takagishi, Michiyo Yamamoto, Chika Watanabe, Ayako Fukami, Tsutomu Fukuwatari, Nobuaki Ozaki, Yoshiharu Murata, Yusuke Seino
Publikováno v:
Diabetes
Glucagon is believed to be one of the most important peptides for upregulating blood glucose levels. However, homozygous glucagon–green fluorescent protein (gfp) knock-in mice (Gcggfp/gfp: GCGKO) are normoglycemic despite the absence of proglucagon
Autor:
Akira Uchida, Yoshihisa Sugimura, Yoshiko Takagishi, Yoshiharu Murata, N. Sato, Yoshitaka Hayashi, Shizu Hayasaka, Y. Kano, K. Oyama, Yutaka Oiso, Takashi Murase
Publikováno v:
Diabetologia. 52:962-971
Maternal diabetes during pregnancy increases the risk of congenital malformations such as neural tube defects (NTDs). Although the mechanism of this effect is uncertain, it is known that levels of nitric oxide synthase (NOS) and nitric oxide are elev
Autor:
Yoshiharu Murata, Akira Mizoguchi, Yoshiko Takagishi, Masanobu Kano, Tetsuro Kayahara, Kouichi Hashimoto, Hiroyuki Otsuka, Masahiko Watanabe
Publikováno v:
Developmental Neurobiology. 67:909-923
Myosin Va is an actin-based molecular motor that is involved in organelle transport and membrane trafficking. Here, we explored the role of myosin Va in the formation of synaptic circuitry by examining climbing fiber (CF) innervation of Purkinje cell
Autor:
Yoshiharu Murata, Luni Emdad, Itsuo Kodama, Mahmud Uzzaman, Chieko Sasano, Yoshiko Takagishi, Kaichiro Kamiya, Haruo Honjo, Atsuya Shimizu
Publikováno v:
Circulation Journal. 71:382-389
Background Altered expression and distribution of gap junctions might provide substrates for abnormal conduction and arrhythmogenesis in the heart, but little is known about the regulation of gap junctions under pathological conditions. The organizat